Ser1700
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Home > Phosphorylation Site Page: > Ser1700  -  CACNA1C (rabbit)

Site Information
PEIRRAIsGDLtAEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4714250

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 4 ) , mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 4 )
Relevant cell line - cell type - tissue:
myocyte-heart ( 1 , 3 ) , oocyte ( 2 ) , tsA201 (epithelial) ( 1 , 3 , 4 )

Upstream Regulation
Regulatory protein:
CAMK2N1 (human) ( 4 )
Kinases, in vitro:
CAMK2A (human) ( 4 ) , PKACA (human) ( 4 , 5 )
Treatments:
autocamtide_inhibitory_peptide ( 4 ) , ciclosporin ( 4 ) , colforsin ( 4 ) , ionomycin ( 4 ) , okadaic_acid ( 4 )

Downstream Regulation
Effects of modification on CACNA1C:
activity, induced ( 4 )

References 

1

Kashihara T, et al. (2017) Angiotensin II activates CaV 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. J Physiol 595, 4207-4225
28295363   Curated Info

2

Oz S, et al. (2017) Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit. J Physiol 595, 3181-3202
28194788   Curated Info

3

Yang L, et al. (2013) β-adrenergic regulation of the L-type Ca2+ channel does not require phosphorylation of α1C Ser1700. Circ Res 113, 871-80
23825359   Curated Info

4

Fuller MD, et al. (2010) Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal 3, ra70
20876873   Curated Info

5

Leach RN, Brickley K, Norman RI (1996) Cyclic AMP-dependent protein kinase phosphorylates residues in the C-terminal domain of the cardiac L-type calcium channel alpha1 subunit. Biochim Biophys Acta 1281, 205-12
8664319   Curated Info