Ser1670
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Home > Phosphorylation Site Page: > Ser1670  -  CACNA1C (mouse)

Site Information
PEIRRAIsGDLTAEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4714250

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 , 5 , 6 , 7 ) , mutation of modification site ( 2 ) , phospho-antibody ( 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
CS ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ADRB1 (mouse) ( 5 )
Treatments:
isoproterenol ( 2 )

Downstream Regulation
Effects of modification on CACNA1C:
phosphorylation ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Patriarchi T, et al. (2016) Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J 35, 1330-45
27103070   Curated Info

3

Levin MD, et al. (2016) KATP channel gain-of-function leads to increased myocardial L-type Ca2+ current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A 113, 6773-8
27247394   Curated Info

4

Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45
25162660   Curated Info

5

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

6

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info