Ser81
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Home > Phosphorylation Site Page: > Ser81  -  ERG (human)

Site Information
QVNGSRNsPDECsVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4712347

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , pancreatic ductal adenocarcinoma ( 3 ) , prostate cancer ( 4 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 3 ) , breast ( 2 ) , E.coli (bacterial) ( 1 ) , LNCaP (prostate cell) ( 4 ) , RWPE1 (prostate cell) ( 1 ) , VCap (prostate cell) ( 4 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 4 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 4 )

References 

1

Kedage V, Strittmatter BG, Dausinas PB, Hollenhorst PC (2017) Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation. J Biol Chem 292, 17225-17235
28887309   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

4

Singareddy R, et al. (2013) Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG Fusions. Mol Cancer Res 11, 1349-61
23918819   Curated Info