Ser123
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Home > Phosphorylation Site Page: > Ser123  -  IRF3 (human)

Site Information
DFSQPDTsPDTNGGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4712212

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Cot (human) ( 2 ) , GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3A (human) ( 1 ) , GSK3B (human) ( 1 )
Treatments:
lithium ( 1 )

Downstream Regulation
Effects of modification on IRF3:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 1 , 2 )
Induce interaction with:
IRF7 (human) ( 2 )

References 

1

Wang JT, et al. (2014) Glycogen synthase kinase 3 negatively regulates IFN regulatory factor 3 transactivation through phosphorylation at its linker region. Innate Immun 20, 78-87
23685991   Curated Info

2

Schmid S, Sachs D, tenOever BR (2014) Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus. J Biol Chem 289, 299-311
24275658   Curated Info