Ser282
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Home > Phosphorylation Site Page: > Ser282  -  MLK3 (mouse)

Site Information
WHKtTQMsAAGTYAW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448262

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
'heart, ventricle' ( 1 ) , 293 (epithelial) ( 1 ) , 3T3 (fibroblast) ( 2 ) , adipose tissue ( 3 ) , MEF (fibroblast) ( 3 )

Upstream Regulation
Regulatory protein:
Src iso1 (mouse) ( 2 )
Putative in vivo kinases:
PKG1 (human) ( 1 )
Kinases, in vitro:
PKG1 (human) ( 1 )
Treatments:
cGMP_analog ( 1 ) , palmitate ( 2 , 3 ) , sildenafil ( 1 )

Downstream Regulation
Effects of modification on MLK3:
enzymatic activity, induced ( 1 )

References 

1

Calamaras TD, et al. (2021) Mixed Lineage Kinase 3 mediates PKG1α impact on cardiac function and controls blood pressure through separate mechanisms. JCI Insight
34324442   Curated Info

2

Holzer RG, et al. (2011) Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147, 173-84
21962514   Curated Info

3

Jaeschke A, Davis RJ (2007) Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 27, 498-508
17679097   Curated Info