Ser207

Site Information
IAELDtLsEEsykDs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4710771

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 )
Disease tissue studied:	bone cancer ( 19 ) , osteosarcoma ( 19 ) , breast cancer ( 2 , 6 , 10 , 11 ) , breast ductal carcinoma ( 6 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 , 6 ) , cervical cancer ( 20 ) , cervical adenocarcinoma ( 20 ) , leukemia ( 13 ) , acute myelogenous leukemia ( 13 ) , hepatocellular carcinoma, surrounding tissue ( 18 ) , lung cancer ( 4 , 11 , 16 ) , non-small cell lung cancer ( 11 ) , non-small cell lung adenocarcinoma ( 4 ) , lymphoma ( 7 ) , Burkitt's lymphoma ( 7 ) , follicular lymphoma ( 7 ) , mantle cell lymphoma ( 7 ) , ovarian cancer ( 6 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:	'stem, embryonic' ( 22 ) , A498 (renal) ( 17 ) , BJAB (B lymphocyte) ( 7 ) , breast ( 1 , 6 ) , BT-20 (breast cell) ( 11 ) , BT-549 (breast cell) ( 11 ) , Calu 6 (pulmonary) ( 11 ) , CL1-0 (pulmonary) ( 16 ) , CL1-1 (pulmonary) ( 16 ) , CL1-2 (pulmonary) ( 16 ) , CL1-5 (pulmonary) ( 16 ) , FL-318 (B lymphocyte) ( 7 ) , H2009 (pulmonary) ( 11 ) , H2077 (pulmonary) ( 11 ) , H2887 (pulmonary) ( 11 ) , H322M (pulmonary) ( 11 ) , HCC2279 (pulmonary) ( 11 ) , HCC366 (pulmonary) ( 11 ) , HCC78 (pulmonary) ( 11 ) , HeLa (cervical) ( 5 , 15 , 21 , 25 ) , HeLa S3 (cervical) ( 20 ) , hepatocyte-liver ( 18 ) , HOP62 (pulmonary) ( 11 ) , HUES-9 ('stem, embryonic') ( 14 ) , JEKO-1 (B lymphocyte) ( 7 ) , Jurkat (T lymphocyte) ( 9 , 24 ) , KG-1 (myeloid) ( 13 ) , leukocyte-blood ( 19 ) , liver ( 8 ) , MCF-7 (breast cell) ( 2 ) , MDA-MB-231 (breast cell) ( 11 ) , MDA-MB-468 (breast cell) ( 11 ) , NCEB-1 (B lymphocyte) ( 7 ) , NCI-H1395 (pulmonary) ( 11 ) , NCI-H1648 (pulmonary) ( 11 ) , NCI-H2030 (pulmonary) ( 11 ) , NCI-H2172 (pulmonary) ( 11 ) , NCI-H322 (pulmonary) ( 11 ) , ovary ( 6 ) , PC9 (pulmonary) ( 4 ) , PC9-IR (pulmonary) ( 4 ) , Raji (B lymphocyte) ( 7 ) , REC-1 (B lymphocyte) ( 7 ) , SKBr3 (breast cell) ( 10 ) , SU-DHL-4 (B lymphocyte) ( 7 ) , WM115 (melanocyte) ( 23 ) , WM239A (melanocyte) ( 3 )

Upstream Regulation
Treatments:	metastatic potential ( 16 ) , U0126 ( 23 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290 27362937 Curated Info
3	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
4	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
5	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
6	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
7	Rolland D, et al. (2014) Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas. Am J Pathol 184, 1331-42 24667141 Curated Info
8	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
9	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
10	Imami K, et al. (2012) Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics 11, 1741-57 22964224 Curated Info
11	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
12	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
13	Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56 22115753 Curated Info
14	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
15	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
16	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info
17	Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62 20071362 Curated Info
18	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
19	Raijmakers R, et al. (2010) Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem 82, 824-32 20058876 Curated Info
20	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
21	Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808 19651622 Curated Info
22	Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13 19664994 Curated Info
23	Old WM, et al. (2009) Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell 34, 115-31 19362540 Curated Info
24	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info
25	Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50 18452278 Curated Info