Thr48
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Home > Phosphorylation Site Page: > Thr48  -  NCCT (mouse)

Site Information
sHLtHGstLyMRtFG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4709842

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'kidney, cortex' ( 1 ) , kidney ( 1 , 3 ) , oocyte ( 2 ) , testis ( 1 )

Upstream Regulation
Regulatory protein:
STLK3 (mouse) ( 1 ) , WNK4 (mouse) ( 1 )
Kinases, in vitro:
WNK4 (human) ( 2 )
Treatments:
angiotensin_2 ( 1 ) , choline ( 1 ) , high-potassium diet ( 1 ) , KCl ( 1 ) , low-potassium diet ( 1 ) , spironolactone ( 1 )

Downstream Regulation
Effects of modification on NCCT:
activity, induced ( 2 ) , phosphorylation ( 2 )

References 

1

CastaƱeda-Bueno M, et al. (2014) Modulation of NCC activity by low and high K+ intake: insights into the signaling pathways involved. Am J Physiol Renal Physiol 306, F1507-19
24761002   Curated Info

2

Na T, Wu G, Peng JB (2012) Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions. Biochem Biophys Res Commun 419, 293-8
22342722   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info