Ser16

Site Information
CPsPstssEGTRIKK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4707236

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 1 ) , brain ( 4 ) , kidney ( 4 ) , lung ( 4 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 3 ) , pancreas ( 4 ) , spleen ( 4 )

Upstream Regulation
Treatments:	insulin ( 1 ) , MK-2206 ( 1 )

References
1	Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20 23684622 Curated Info
2	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
3	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info