Ser243
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Home > Phosphorylation Site Page: > Ser243  -  NFAT2 (mouse)

Site Information
PRHsPSTsPRAsITE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4700879

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 1 ) , BaF3 ('B lymphocyte, precursor') [JAK3 (human), transfection] ( 2 ) , C2C12 (myoblast) ( 1 ) , lung ( 4 ) , RAW 264.7 (macrophage) ( 3 ) , spleen ( 4 )

Upstream Regulation
Putative in vivo kinases:
ROCK2 (human) ( 1 )
Treatments:
exercise ( 1 ) , high-fat diet ( 1 )

Downstream Regulation
Effects of modification on NFAT2:
activity, inhibited ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Koo JH, et al. (2017) Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism. J Clin Invest 127, 3845-3860
28920922   Curated Info

2

Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia
28852199   Curated Info

3

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

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