Tyr473
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Home > Phosphorylation Site Page: > Tyr473  -  UGDH (human)

Site Information
VSSKRIPyAPsGEIP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4699451
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 3 , 4 , 5 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
gastric cancer ( 4 , 5 ) , gastric carcinoma ( 5 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 , 3 ) , non-small cell lung adenocarcinoma ( 2 , 3 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 2 ) , lung ( 2 ) , MKN-45 (gastric) ( 4 , 5 ) , NCI-H1299 (pulmonary) ( 2 ) , NCI-H2228 (pulmonary) ( 3 )

Upstream Regulation
Regulatory protein:
MEK1 (human) ( 2 )
Treatments:
BIRB-0796 ( 2 ) , EGF ( 2 ) , TGF-beta ( 2 ) , U0126 ( 2 )

Downstream Regulation
Effects of modification on UGDH:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , cell motility, induced ( 2 ) , RNA stability, induced ( 1 ) , transcription, induced ( 2 )
Induce interaction with:
HuR (human) ( 1 , 2 ) , Other ( 1 )
Inhibit interaction with:
Other ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
lung cancer ( 2 )

References 

1

Liu Y, Li Y, Li G, Chu H (2023) The molecular mechanism of Y473 phosphorylation of UGDH relieves the inhibition effect of UDP-glucose on HuR. Phys Chem Chem Phys 25, 8714-8724
36896759   Curated Info

2

Wang X, et al. (2019) UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature 571, 127-131
31243371   Curated Info

3

Rikova K (2013) CST Curation Set: 18449; Year: 2012; Biosample/Treatment: cell line, H2228/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) MultiMab(TM) Rabbit mAb mix Cat#: 8954
Curated Info

4

Rikova K (2012) CST Curation Set: 16137; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) MultiMab(TM) Rabbit mAb mix Cat#: 8954
Curated Info

5

Rikova K (2012) CST Curation Set: 13326; Year: 2012; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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