Ser266
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Home > Phosphorylation Site Page: > Ser266  -  MOR-1 (rat)

Site Information
LKsVRMLsGSKEKDR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447782

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 ) , oocyte ( 2 ) , oocyte [CPEB (mouse)] ( 3 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 1 , 2 , 3 )
Treatments:
DAMGO ( 3 )

Downstream Regulation
Effects of modification on MOR-1:
receptor desensitization, altered ( 2 , 3 )

References 

1

Brüggemann I, Schulz S, Wiborny D, Höllt V (2000) Colocalization of the mu-opioid receptor and calcium/calmodulin-dependent kinase II in distinct pain-processing brain regions. Brain Res Mol Brain Res 85, 239-50
11146127   Curated Info

2

Koch T, et al. (2000) Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling. Mol Pharmacol 58, 328-34
10908300   Curated Info

3

Koch T, et al. (1997) Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization. J Neurochem 69, 1767-70
9326307   Curated Info