Ser829
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Home > Phosphorylation Site Page: > Ser829  -  PKD2 (human)

Site Information
HSSRRRGsISSGVSY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4696848

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PKD1 (mouse) ( 3 )
Putative in vivo kinases:
PKACA (human) ( 2 , 3 )
Kinases, in vitro:
AurA (human) ( 3 ) , PKACA (human) ( 3 )
Putative upstream phosphatases:
PPP1CA (human) ( 2 , 3 )
Phosphatases, in vitro:
PPP1CA (human) ( 3 ) , PPP2CA (human) ( 3 )
Treatments:
cAMP_analog ( 2 , 3 ) , ciclosporin ( 3 ) , H-89 ( 2 , 3 ) , NKH_477 ( 3 ) , okadaic_acid ( 3 ) , PKI ( 2 ) , PKI-(14-22)amide ( 3 ) , siRNA ( 3 ) , tautomycin ( 3 ) , vanadate ( 2 )

Downstream Regulation
Effects of modification on PKD2:
activity, induced ( 2 , 3 )
Effects of modification on biological processes:
cell cycle regulation ( 3 ) , cell growth, induced ( 3 ) , transcription, induced ( 3 )

References 

1

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell
32645325   Curated Info

2

Cantero Mdel R, et al. (2015) The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function. J Biol Chem 290, 23888-96
26269590   Curated Info

3

Streets AJ, Wessely O, Peters DJ, Ong AC (2013) Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. Hum Mol Genet 22, 1924-39
23390129   Curated Info