Ser398
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Home > Phosphorylation Site Page: > Ser398  -  PTEN (mouse)

Site Information
PFDEDQHsQITKV__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4695758

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATR (human) ( 1 )
Putative in vivo kinases:
ATM (mouse) ( 1 )
Treatments:
etoposide ( 1 ) , ionizing_radiation ( 1 ) , KU-55933 ( 1 ) , MNNG ( 1 ) , NVP-BKM120 ( 1 ) , siRNA ( 1 ) , VE-821 ( 1 )

Downstream Regulation
Effects of modification on PTEN:
methylation ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , DNA repair, induced ( 1 )
Induce interaction with:
MDC1 (human) ( 1 ) , WHSC1 (mouse) ( 1 )

References 

1

Zhang J, et al. (2019) PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov
31217297   Curated Info