Tyr1354
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Home > Phosphorylation Site Page: > Tyr1354  -  Met (mouse)

Site Information
yVHVNATyVNVKCVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448473

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Met:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 1 , 2 )
Induce interaction with:
GAB1 (mouse) ( 1 ) , GRB2 (mouse) ( 1 ) , PIK3C2A (mouse) ( 1 ) , SHC1 (mouse) ( 1 )

References 

1

Tulasne D, et al. (1999) The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. Mol Biol Cell 10, 551-65
10069803   Curated Info

2

Weidner KM, Sachs M, Riethmacher D, Birchmeier W (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-601
7708691   Curated Info