Tyr1001
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Home > Phosphorylation Site Page: > Tyr1001  -  Met (mouse)

Site Information
VsNEsVDyRATFPED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448469

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 5 )
Disease tissue studied:
testicular cancer ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Met:
ubiquitination ( 4 )
Effects of modification on biological processes:
cell motility, altered ( 5 )

References 

1

Ferrando IM, et al. (2012) Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Mol Cell Proteomics 11, 355-69
22499769   Curated Info

2

Zhou J (2010) CST Curation Set: 9109; Year: 2010; Biosample/Treatment: cell line, P19/untreated; Disease: testicular cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

3

Schmelzle K, et al. (2006) Temporal dynamics of tyrosine phosphorylation in insulin signaling. Diabetes 55, 2171-9
16873679   Curated Info

4

Taher TE, et al. (2002) c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J Immunol 169, 3793-800
12244174   Curated Info

5

Weidner KM, Sachs M, Riethmacher D, Birchmeier W (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-601
7708691   Curated Info