Ser473
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Site Information
RPHFPQFsysAsGtA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447855
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 442 , 453 ) , flow cytometry ( 70 , 92 , 176 , 191 , 244 , 246 ) , immunoassay ( 22 , 24 , 31 , 38 , 40 , 56 , 65 , 134 , 155 , 168 , 169 ) , immunoprecipitation ( 83 , 88 , 92 , 93 , 111 , 130 , 131 , 142 , 157 , 167 , 172 , 211 , 218 , 257 , 261 , 273 , 288 , 472 , 473 ) , mass spectrometry ( 83 , 94 , 97 , 107 , 145 , 152 , 314 ) , mass spectrometry (in vitro) ( 142 , 210 ) , microscopy-colocalization with upstream kinase ( 287 ) , mutation of modification site ( 56 , 93 , 142 , 167 , 182 , 223 , 263 , 276 , 278 , 322 , 330 , 359 , 394 , 396 , 404 , 410 , 442 , 453 , 456 , 460 , 473 ) , peptide sequencing ( 235 , 397 ) , phospho-antibody ( 14 , 15 , 16 , 17 , 19 , 20 , 22 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 75 , 76 , 78 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 139 , 140 , 142 , 143 , 144 , 146 , 147 , 148 , 149 , 150 , 151 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 171 , 172 , 173 , 174 , 175 , 177 , 178 , 179 , 180 , 181 , 182 , 184 , 185 , 186 , 189 , 190 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 278 , 279 , 280 , 281 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 308 , 309 , 310 , 311 , 312 , 313 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 330 , 331 , 332 , 333 , 334 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 , 350 , 351 , 352 , 353 , 354 , 355 , 356 , 358 , 359 , 360 , 361 , 362 , 363 , 364 , 365 , 367 , 368 , 369 , 370 , 372 , 373 , 374 , 375 , 376 , 377 , 378 , 379 , 380 , 381 , 382 , 383 , 384 , 385 , 386 , 387 , 389 , 390 , 391 , 392 , 393 , 394 , 395 , 396 , 398 , 399 , 400 , 401 , 402 , 403 , 404 , 405 , 406 , 408 , 409 , 410 , 411 , 412 , 413 , 414 , 415 , 416 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 424 , 425 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 445 , 446 , 447 , 448 , 449 , 450 , 451 , 452 , 454 , 455 , 456 , 457 , 458 , 459 , 460 , 461 , 462 , 463 , 464 , 465 , 466 , 467 , 468 , 469 , 470 , 471 , 472 , 473 ) , western blotting ( 14 , 15 , 16 , 17 , 19 , 20 , 22 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 71 , 72 , 75 , 76 , 78 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 125 , 126 , 127 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 139 , 140 , 141 , 142 , 143 , 144 , 146 , 147 , 148 , 149 , 150 , 151 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 171 , 172 , 173 , 174 , 175 , 177 , 178 , 179 , 180 , 181 , 182 , 184 , 185 , 186 , 189 , 190 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 278 , 279 , 280 , 281 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 308 , 309 , 310 , 311 , 312 , 313 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 330 , 331 , 332 , 333 , 334 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 , 350 , 351 , 352 , 353 , 355 , 356 , 359 , 360 , 362 , 363 , 364 , 365 , 367 , 373 , 377 , 383 , 384 , 387 , 389 , 390 , 391 , 392 , 395 , 396 , 397 , 399 , 400 , 401 , 403 , 404 , 406 , 409 , 410 , 413 , 415 , 416 , 420 , 422 , 423 , 427 , 428 , 431 , 433 , 434 , 436 , 437 , 438 , 439 , 441 , 445 , 446 , 447 , 449 , 450 , 451 , 452 , 455 , 456 , 459 , 462 , 466 , 468 , 469 , 470 , 471 , 472 , 473 )
Disease tissue studied:
Alzheimer's disease ( 80 , 182 ) , bone cancer ( 180 ) , brain cancer ( 263 , 275 ) , glioblastoma ( 263 , 275 ) , glioma ( 58 , 263 , 275 ) , breast cancer ( 31 , 41 , 55 , 83 , 91 , 258 , 274 , 280 , 321 , 468 ) , breast adenocarcinoma ( 31 , 41 ) , breast ductal carcinoma ( 41 ) , breast cancer, triple negative ( 31 , 41 ) , cervical cancer ( 151 , 437 ) , cervical adenocarcinoma ( 437 ) , cervical squamous cell carcinoma ( 151 ) , colorectal cancer ( 180 , 223 , 322 , 422 ) , colorectal carcinoma ( 180 , 223 , 322 , 422 ) , endometrial cancer ( 359 ) , endometrial adenocarcinoma ( 359 ) , kidney cancer ( 134 ) , leukemia ( 29 , 136 , 155 , 194 ) , chronic lymphocytic leukemia ( 29 ) , chronic myelogenous leukemia ( 155 ) , T cell leukemia ( 136 ) , liver cancer ( 63 , 102 , 245 , 276 ) , hepatocellular carcinoma ( 102 ) , lung cancer ( 223 , 308 , 342 , 387 ) , mesothelioma ( 387 ) , non-small cell lung cancer ( 223 , 308 ) , lymphoma ( 385 , 440 ) , B cell lymphoma ( 440 ) , T cell lymphoma ( 385 ) , neuroblastoma ( 57 , 94 , 112 , 126 , 195 , 415 , 441 ) , ovarian cancer ( 333 ) , pancreatic cancer ( 199 , 223 , 288 ) , pancreatic carcinoma ( 223 , 288 ) , multiple myeloma ( 157 , 433 ) , prostate cancer ( 220 , 270 ) , melanoma skin cancer ( 68 , 396 ) , fibrosarcoma of soft tissue ( 433 , 456 ) , diabetes mellitus ( 280 , 350 ) , type 2 diabetes ( 75 , 239 , 280 , 350 ) , Huntington's disease ( 131 ) , Lafora disease ( 252 ) , Duchenne muscular dystrophy ( 84 ) , schizophrenia ( 413 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 107 , 145 ) , 'brain, cerebral cortex' ( 26 , 75 , 126 , 139 , 234 , 363 , 406 , 413 , 452 ) , 'brain, embryonic' ( 314 ) , 'brain, embryonic' [BAG1 (mouse)] ( 371 ) , 'brain, hippocampus' ( 52 , 75 , 126 , 139 , 240 , 323 , 363 ) , 'brain, hippocampus' [APP (human), genetic knockin] ( 182 ) , 'brain, hippocampus, CA1 region' ( 47 ) , 'brain, nucleus accumbens' ( 95 ) , 'brain, striatum' ( 131 , 363 , 374 , 414 ) , 'fat, brown'-'fat, brown' ( 204 , 228 ) , 'heart, embryo' ( 65 ) , 'liver, fetal' ( 353 ) , 'muscle, skeletal' ( 50 , 62 , 76 , 130 , 142 , 193 , 209 , 228 , 259 , 262 , 267 , 284 , 292 , 294 , 295 , 337 , 386 , 400 , 403 , 419 ) , 'muscle, skeletal' [APPL (human), homozygous knockout] ( 123 ) , 'muscle, skeletal' [DNAPK (mouse), homozygous knockout] ( 281 ) , 'muscle, skeletal' [genetic knockin] ( 123 ) , 'muscle, skeletal' [RICTOR (mouse), homozygous knockout] ( 256 , 303 ) , 'neuron, cortical' ( 38 , 158 , 251 , 304 ) , 'neuron, cortical'-brain ( 94 , 150 , 376 ) , 'neuron, cortical'-brain [NYAP2 (mouse), homozygous knockout] ( 162 ) , 'neuron, hippocampal' ( 158 ) , 'neuron, striatal' ( 72 ) , 'neuron, striatal'-brain ( 361 ) , 'neuron, superior cervical ganglion' ( 286 ) , 'renal, podocyte' ( 148 , 222 ) , 'stem, embryonic' ( 292 ) , 'stem, mesenchymal' ( 164 ) , 'stem, neural' ( 71 ) , 293 (epithelial) ( 37 , 88 , 168 , 205 , 217 , 238 , 254 , 263 , 274 , 309 , 365 , 376 , 378 , 425 , 473 ) , 293E (epithelial) ( 322 ) , 32D (myeloid) ( 201 ) , 3T3 (fibroblast) [INSR (human)] ( 337 ) , 3T3 (fibroblast) [INSR (mouse), transfection] ( 273 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 375 , 384 , 387 , 391 , 394 , 431 , 436 , 439 , 444 , 455 , 461 , 463 , 464 , 465 ) , 3T3 (fibroblast) [Src (human)] ( 342 ) , 3T3 (fibroblast) ( 66 , 177 , 206 , 226 , 247 , 261 , 264 , 273 , 308 , 321 , 373 , 437 , 438 , 450 , 451 ) , 3T3-L1 (fibroblast) ( 53 , 60 , 186 , 236 , 237 , 241 , 289 , 316 , 318 , 330 , 337 , 350 , 367 , 446 ) , 4T1 (breast cell) ( 31 , 258 , 468 ) , 786-O (renal) ( 134 ) , A-375 (melanocyte) ( 19 ) , A431 (epithelial) ( 223 ) , A549 (pulmonary) ( 223 , 308 ) , adipocyte ( 334 ) , adipocyte [F2RL1 (mouse), homozygous knockout] ( 213 ) , adipocyte [N-CoR1 (mouse), homozygous knockout] ( 165 ) , adipocyte-adipose tissue ( 129 ) , adipocyte-adipose tissue [N-CoR1 (mouse), homozygous knockout] ( 165 ) , adipose tissue ( 25 , 45 , 50 , 51 , 53 , 62 , 104 , 130 , 194 , 292 , 337 , 389 , 398 ) , adipose tissue [DNAPK (mouse), homozygous knockout] ( 281 ) , adipose tissue [F2RL1 (mouse), homozygous knockout] ( 213 ) , adipose tissue [p70S6K (mouse), homozygous knockout] ( 397 ) , adipose tissue [RICTOR (mouse), homozygous knockout] ( 256 ) , AE7 ( 325 ) , alpha-TC6 (pancreatic) ( 54 ) , alphaT3-1 (pituitary cell) ( 135 ) , AML12 (hepatic) ( 46 ) , aorta ( 324 ) , artery ( 297 ) , AS-B634 ( 55 ) , astrocyte-'brain, striatum' ( 405 ) , AV12 ('neuron, neostriatal') ( 401 ) , B lymphocyte ( 16 , 29 , 67 , 351 ) , B lymphocyte [BCAP (mouse), homozygous knockout] ( 302 ) , B lymphocyte [CD19 (mouse), homozygous knockout] ( 302 ) , B lymphocyte-spleen ( 124 , 169 , 233 ) , B lymphocyte-spleen [PTEN (mouse), transgenic] ( 248 ) , B16F10 ( 68 ) , B9 (fibroblast) ( 433 ) , BAEC (endothelial) ( 369 ) , BaF3 ('B lymphocyte, precursor') [EGFR (human)] ( 342 ) , BaF3 ('B lymphocyte, precursor') ( 146 , 229 , 243 , 273 , 315 , 319 , 339 , 378 , 408 , 459 ) , BALB/MK (keratinocyte) ( 472 ) , BE (melanocyte) ( 396 ) , beta TC3 (pancreatic) ( 288 ) , beta-pancreas ( 343 ) , beta-pancreas [INSR (mouse), transgenic] ( 224 ) , BLMVEC (endothelial) ( 410 ) , BMMC (mast) ( 208 , 469 ) , bone marrow ( 30 , 124 , 339 , 399 ) , brain ( 14 , 32 , 35 , 133 , 152 , 296 , 356 ) , brain [CDK5R1 (mouse)] ( 296 ) , brain [laforin (mouse), homozygous knockout] ( 252 ) , brain [NYAP2 (mouse), homozygous knockout] ( 162 ) , breast [PDK1 (mouse), homozygous knockout] ( 91 ) , breast cell ( 83 ) , BT-549 (breast cell) ( 31 ) , C141 (epidermal) ( 453 ) , C2C12 (myoblast) [LIN28A (mouse), transfection] ( 178 ) , C2C12 (myoblast) ( 15 , 17 , 20 , 28 , 43 , 44 , 64 , 98 , 130 , 172 , 173 , 253 , 301 , 305 , 313 , 326 , 383 , 467 ) , C3H10T1/2 (fibroblast) ( 293 ) , Calu-1 (squamous) ( 308 ) , CaSki (cervical) ( 151 ) , CD4+ (T lymphocyte) ( 39 , 40 , 70 , 191 ) , CD8+ (T lymphocyte) ( 42 , 70 ) , CEF ( 460 ) , CHO (fibroblast) [Tau iso8 (human)] ( 355 ) , CHO (fibroblast) ( 65 , 93 , 466 ) , CMT-93 (intestinal) ( 422 ) , colon ( 56 , 81 ) , COS (fibroblast) ( 146 , 252 , 273 , 378 , 429 , 442 ) , COS7 (fibroblast) ( 154 ) , CTL-EN (T lymphocyte) ( 306 ) , CTLL-2 (T lymphocyte) ( 447 ) , D3 mES (stem) ( 61 ) , diaphragm ( 84 ) , DLD1 (intestinal) ( 223 ) , DU 145 (prostate cell) ( 270 ) , E14tg2a ('stem, embryonic') ( 99 , 395 ) , embryo ( 152 , 353 ) , endothelial ( 225 , 283 ) , epithelial ( 287 ) , epithelial-lens ( 320 ) , ES (stem) ( 109 , 184 ) , ESC-CMs ('stem, embryonic') ( 61 ) , F9 (testicular) ( 442 ) , Fao (hepatic) ( 276 ) , fat ( 147 ) , FDCP-1 (myeloid) ( 379 ) , fibroblast ( 24 , 56 , 85 ) , fibroblast-embryo [BAG1 (mouse)] ( 371 ) , FL ( 194 ) , G361 (melanocyte) ( 432 ) , GD25 (fibroblast) ( 402 , 428 ) , GSCs (glial) ( 58 ) , GT1-7 (neuron) ( 354 ) , H9c2 (myoblast) ( 337 ) , HaCaT (keratinocyte) ( 86 ) , HCC1937 (breast cell) ( 41 ) , HCC38 (breast cell) ( 41 ) , HCCLM3 (hepatic) ( 102 ) , HCT116 (intestinal) ( 180 ) , HCT15 (intestinal) ( 223 ) , heart ( 32 , 59 , 121 , 209 , 221 , 292 , 298 , 310 , 337 , 360 , 418 ) , heart [AMPKA2 (mouse), homozygous knockout] ( 279 ) , heart [DNAPK (human), transfection] ( 281 ) , HEK293T (epithelial) ( 32 , 38 , 93 , 122 , 136 , 142 , 150 , 160 , 210 , 211 , 257 , 322 , 470 ) , HeLa (cervical) ( 143 , 167 , 180 , 200 , 217 , 223 , 274 , 322 , 378 , 397 ) , HeLa S3 (cervical) ( 437 ) , hematopoietic stem cells ( 176 ) , hepatocyte ( 205 , 245 ) , hepatocyte-liver ( 46 , 144 , 149 , 203 , 266 , 343 ) , hepatocyte-liver [eIF2-alpha (mouse), homozygous knockout] ( 276 ) , hepatocyte-liver [TSC1 (mouse), homozygous knockout] ( 185 ) , HepG2 (hepatic) ( 63 , 245 , 473 ) , HT-29 (intestinal) ( 322 ) , HUVEC (endothelial) ( 283 , 334 ) , IC2 (mast) ( 420 ) , intestine ( 100 ) , Ishikawa (endometrial) ( 359 ) , J558L (B lymphocyte) ( 157 ) , J774 (macrophage) ( 449 ) , JB (epithelial) ( 390 , 430 ) , Jurkat (T lymphocyte) ( 278 ) , Jurkat E6-1 (T lymphocyte) ( 136 ) , K562 (erythroid) ( 155 ) , keratinocyte ( 364 ) , keratinocyte-skin ( 358 , 362 ) , keratinocyte-skin [IGF1 (mouse)] ( 365 ) , kidney ( 32 ) , L6 (myoblast) ( 226 ) , liver ( 25 , 32 , 33 , 45 , 48 , 50 , 51 , 62 , 63 , 104 , 130 , 147 , 152 , 168 , 175 , 190 , 194 , 202 , 205 , 211 , 228 , 242 , 272 , 280 , 292 , 337 , 400 , 448 ) , liver [DNAPK (mouse), homozygous knockout] ( 281 ) , liver [p70S6K (mouse), homozygous knockout] ( 397 ) , liver [RICTOR (mouse), homozygous knockout] ( 256 ) , LU-NB-1 ( 34 ) , lung ( 31 , 32 , 283 , 386 ) , lymph node ( 16 ) , lymphocyte ( 39 , 92 , 97 , 413 ) , lymphocyte-spleen ( 82 , 96 , 101 ) , lymphocyte-spleen [p53 (mouse), transfection] ( 285 ) , M059J (glial) ( 263 , 311 ) , M1 (myeloid) ( 155 ) , M2-10B4 ( 110 ) , macrophage-bone marrow ( 37 , 51 , 80 , 89 , 106 , 317 , 332 , 423 ) , macrophage-peritoneum ( 255 ) , mammary gland ( 31 , 87 ) , mast-bone marrow ( 105 , 348 , 394 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 250 ) , MCF-7 (breast cell) ( 31 , 55 , 274 , 321 ) , MDA-MB-231 (breast cell) ( 31 ) , MDA-MB-453 (breast cell) ( 280 ) , MDA-MB-468 (breast cell) ( 31 , 41 ) , MEC1 (B lymphocyte) ( 29 ) , MEF (fibroblast) [Akt1 (mouse), heterozygous knockout] ( 244 ) , MEF (fibroblast) [Akt1 (mouse), homozygous knockout] ( 179 ) , MEF (fibroblast) [Akt2 (mouse), homozygous knockout] ( 244 ) , MEF (fibroblast) [BAG4 (mouse), homozygous knockout] ( 181 ) , MEF (fibroblast) [DNAPK (mouse), homozygous knockout] ( 281 ) , MEF (fibroblast) [EIF4E (mouse), genetic knockin] ( 220 ) , MEF (fibroblast) [GADD34 (human)] ( 309 ) , MEF (fibroblast) [IGF1R (mouse)] ( 370 , 382 , 392 ) , MEF (fibroblast) [LKB1 (mouse)] ( 409 ) , MEF (fibroblast) [mTOR (mouse), homozygous knockout] ( 274 ) , MEF (fibroblast) [NRas (mouse), homozygous knockout] ( 471 ) , MEF (fibroblast) [PDGFRA (mouse), genetic knockin] ( 271 ) , MEF (fibroblast) [PKR (mouse), homozygous knockout] ( 239 ) , MEF (fibroblast) [RICTOR (human), homozygous knockout] ( 217 ) , MEF (fibroblast) [Sin1 (mouse), homozygous knockout] ( 227 , 268 ) , MEF (fibroblast) [TMEM55B (mouse), homozygous knockout] ( 260 ) , MEF (fibroblast) ( 14 , 15 , 32 , 37 , 88 , 130 , 134 , 137 , 143 , 153 , 154 , 156 , 160 , 163 , 166 , 198 , 200 , 214 , 215 , 218 , 230 , 231 , 236 , 238 , 249 , 262 , 263 , 269 , 275 , 291 , 293 , 308 , 311 , 312 , 322 , 330 , 336 , 338 , 344 , 345 , 346 , 347 , 349 , 352 , 427 ) , melanocyte-skin ( 19 ) , MES (pulmonary) ( 387 ) , mesenchymal ( 65 ) , MHCC97-L (hepatic) ( 102 ) , MIA PaCa-2 (pancreatic) ( 223 ) , microglia ( 331 ) , mIMCD-3 (epithelial) ( 445 ) , mLEC (epithelial) ( 192 ) , MLO-Y4 (osteoblast) ( 133 ) , MMC (mesangial) ( 328 ) , MMTV-PyMT (breast cell) [JNK2 (mouse), homozygous knockout] ( 196 ) , MPC-11 (B lymphocyte) ( 433 ) , MS1 (endothelial) ( 383 ) , muscle ( 25 , 51 , 104 , 194 , 350 ) , muscle [laforin (mouse), homozygous knockout] ( 252 ) , muscle [p70S6K (mouse), homozygous knockout] ( 397 ) , MVT-1 (epithelial) ( 83 ) , myeloid ( 332 ) , myoblast ( 295 , 404 ) , myocyte-heart ( 61 , 120 , 125 , 140 , 197 , 305 , 327 , 462 ) , myotubes ( 43 ) , N1E-115 (neuron) ( 94 , 415 ) , NCI-H1299 (pulmonary) ( 223 ) , NCI-H157 (pulmonary) ( 308 ) , Neuro-2a (neuron) ( 57 , 112 , 195 , 441 ) , neuron ( 35 ) , neuron-'brain, cerebral cortex' ( 434 ) , neuron-'brain, cerebral cortex' [STAT1 (mouse), homozygous knockout] ( 434 ) , neuron-'brain, hippocampus' ( 112 ) , neuron-dorsal root ganglia ( 161 ) , neutrophil ( 30 , 127 , 159 ) , NHDF (fibroblast) ( 137 ) , NMuMG (epithelial) ( 111 , 468 ) , NPC (neural crest) ( 26 ) , oocyte ( 22 ) , osteoclast ( 332 ) , ovarian ( 333 ) , ovary ( 22 ) , pancreatic ( 199 ) , PaTu (pancreatic) ( 223 ) , PC-12 (chromaffin) ( 380 ) , PC3 (prostate cell) ( 270 ) , penis ( 412 ) , platelet ( 49 ) , platelet-blood ( 78 , 174 , 411 ) , preadipocyte ( 334 ) , preosteoclast ( 381 ) , prostate ( 244 , 287 ) , prostate [homozygous knockout] ( 189 ) , Rat1 (fibroblast) ( 311 , 349 ) , RAW 264 (macrophage) ( 424 ) , RAW 264.7 (macrophage) ( 37 , 210 ) , RIE (epithelial) ( 349 ) , RWPE1 (prostate cell) ( 36 ) , SCC16-5 (fibroblast) ( 457 ) , sertoli-testis ( 90 ) , SF9 ( 461 ) , SiHa (squamous) ( 151 ) , skin ( 86 ) , SKNSH (neural crest) ( 126 ) , SKOV-3 (ovarian) ( 333 ) , SN4741 (neuron) ( 416 ) , spinal cord ( 71 ) , spleen ( 32 , 124 , 399 ) , SV40 ( 454 ) , SYF (fibroblast) ( 219 ) , T lymphocyte-blood ( 191 , 417 ) , T lymphocyte-lymph node ( 246 ) , T lymphocyte-lymph node [PKCT (mouse), homozygous knockout] ( 216 ) , T lymphocyte-spleen ( 124 , 132 , 207 , 299 , 325 , 341 ) , T lymphocyte-spleen [PKCT (mouse), homozygous knockout] ( 216 ) , T lymphocyte-thymus ( 191 , 385 ) , thoracic aorta ( 340 , 377 ) , thymocyte ( 39 , 235 ) , thymocyte [CBL (mouse), homozygous knockout] ( 232 ) , thyroid [Akt1 (mouse), homozygous knockout] ( 171 ) , U-251 MG (glial) ( 275 ) , U2OS (bone cell) [GR (human)] ( 378 ) , U2OS (bone cell) ( 180 ) , UOK-101 (renal) ( 134 ) , uterus ( 359 , 372 ) , VSMC-aorta ( 393 ) , WEHI-164 (fibroblast) ( 456 ) , WEHI-231 (B lymphocyte) ( 440 )

Upstream Regulation
Regulatory protein:
14-3-3 zeta (mouse) ( 257 ) , ABCB10 (human) ( 46 ) , ACVR2B (mouse) ( 326 ) , ADRB1 (mouse) ( 204 ) , Akt1 (human) ( 287 ) , Akt1 (mouse) ( 103 , 171 , 309 , 469 ) , Akt2 (mouse) ( 175 , 235 ) , Akt3 (mouse) ( 174 ) , ALK (human) ( 229 ) , AMPKA2 (mouse) ( 279 ) , APP (mouse) ( 126 ) , APPL (human) ( 130 ) , APPL2 (human) ( 123 ) , ARRB1 (human) ( 33 ) , AS160 (human) ( 209 ) , ATF6A (mouse) ( 276 ) , ATG5 (mouse) ( 66 ) , BAFF (mouse) ( 351 ) , BAG1 (mouse) ( 371 ) , BAG4 (mouse) ( 181 ) , BCAP (mouse) ( 302 ) , BCR-ABL1 (human) ( 342 ) , BRCA1 (human) ( 187 ) , Brk (human) ( 219 ) , Btk (mouse) ( 469 ) , C3aR (mouse) ( 299 ) , C5aR (mouse) ( 299 ) , CASP1 (mouse) ( 194 ) , caveolin-1 (mouse) ( 184 ) , CBL (mouse) ( 232 ) , Cbl-b (human) ( 39 ) , CD151 (mouse) ( 105 ) , CD19 (mouse) ( 302 ) , CDC42 iso1 (mouse) ( 362 ) , CDH1 (human) ( 58 ) , CDH2 (mouse) ( 234 ) , CDK5 (mouse) ( 296 ) , CDK5R1 (mouse) ( 296 ) , CEP55 (human) ( 14 ) , CLK2 (human) ( 205 ) , CMIP (mouse) ( 148 ) , CREB3L3 (human) ( 45 ) , CXCL12 (human) ( 29 ) , CXCL13 (human) ( 29 ) , DICER1 (mouse) ( 101 ) , DNAPK (mouse) ( 263 , 281 ) , DRP1 (human) ( 28 ) , dystrophin (human) ( 15 ) , EGFR (human) ( 58 ) , EIF4E (mouse) ( 220 ) , ERK5 (human) ( 410 ) , F2RL1 (mouse) ( 213 ) , FAK (mouse) ( 225 ) , FGFR1 (human) ( 315 ) , FOXO1A (human) ( 29 , 230 ) , FOXO1A (mouse) ( 134 , 230 , 334 ) , Fyn (mouse) ( 246 ) , G-alpha(s) (human) ( 53 ) , GAB1 (human) ( 29 ) , GAB2 (mouse) ( 348 ) , GADD34 (human) ( 309 ) , GCN2 (mouse) ( 179 ) , GILZ (human) ( 155 ) , GLRX1 (mouse) ( 320 ) , Gm364 (mouse) ( 22 ) , GPM6A (human) ( 112 ) , GPX1 (mouse) ( 400 ) , GRB10 (human) ( 129 , 146 ) , GRB10 (mouse) ( 108 ) , HER3 (human) ( 65 ) , Huntingtin (mouse) ( 414 ) , ICMT (mouse) ( 427 ) , IFI16 (mouse) ( 300 ) , IFITM3 (human) ( 67 ) , IFITM3 (rat) ( 67 ) , IGF1R (mouse) ( 326 , 407 ) , IKKA (human) ( 154 ) , IKKA (mouse) ( 351 ) , IKKB (human) ( 154 ) , IKKG (human) ( 154 ) , IKKG (mouse) ( 357 ) , IL6R (human) ( 58 ) , ILK (human) ( 164 ) , ILK (mouse) ( 81 , 295 ) , IRS1 (human) ( 54 , 125 , 343 ) , IRS1 (mouse) ( 343 ) , IRS2 (human) ( 54 , 125 ) , IRS2 (mouse) ( 343 ) , IRX3 (mouse) ( 25 ) , ITGA9 (human) ( 339 ) , ITGB1 (human) ( 428 ) , ITGB1 (mouse) ( 267 ) , ITGB3 (mouse) ( 68 ) , JAK2 (mouse) ( 459 ) , JIP1 (mouse) ( 398 ) , JNK1 (mouse) ( 197 ) , JNK2 (mouse) ( 196 ) , K17 (mouse) ( 358 ) , KRas (human) ( 32 ) , KRas (mouse) ( 346 , 472 ) , LAB (mouse) ( 341 ) , laforin (mouse) ( 252 ) , LAMTOR1 (human) ( 231 ) , LAMTOR2 (mouse) ( 231 ) , LIMS1 (human) ( 223 ) , LIMS1 (mouse) ( 223 ) , LIN28A (mouse) ( 178 ) , LIN28B (mouse) ( 178 ) , LKB1 (mouse) ( 294 ) , LPIN1 (mouse) ( 265 ) , LST8 (mouse) ( 338 ) , LYN (human) ( 16 ) , LYN (mouse) ( 469 ) , MEK5 (human) ( 410 ) , Met (human) ( 58 ) , Met (mouse) ( 68 ) , Mnk1 (mouse) ( 308 ) , Mnk2 (mouse) ( 308 ) , MT1 (mouse) ( 360 ) , mTOR (human) ( 37 , 49 ) , mTOR (mouse) ( 90 , 173 ) , Musashi-1 (mouse) ( 100 ) , MYD88 (human) ( 255 ) , N-CoR1 (mouse) ( 165 ) , NF1 (mouse) ( 336 ) , NFkB-p100 (mouse) ( 88 ) , NFkB-p65 (human) ( 33 ) , NLRP3 (mouse) ( 194 ) , nNOS (human) ( 63 ) , NOX4 (human) ( 56 ) , NPM1 (human) ( 229 ) , NRas (mouse) ( 471 ) , NYAP2 (mouse) ( 162 ) , P38A (mouse) ( 218 ) , p53 (mouse) ( 115 ) , p70S6K (mouse) ( 173 ) , PAG (rat) ( 291 ) , PCYT2 (human) ( 40 ) , PD-L1 (human) ( 30 ) , PDGFRA (human) ( 58 ) , PDGFRA (mouse) ( 271 ) , PDK1 (mouse) ( 91 , 292 ) , PERK (mouse) ( 179 ) , PGGT1B (mouse) ( 89 ) , PHB (human) ( 253 ) , PIK3C2A (mouse) ( 446 ) , PIK3CA (mouse) ( 163 ) , PIK3CG (human) ( 159 ) , PIK3R1 (human) ( 154 ) , PIKFYVE (human) ( 142 ) , PIKFYVE (mouse) ( 142 ) , Pim1 (human) ( 270 ) , PKCA (human) ( 216 , 364 ) , PKCA (mouse) ( 283 ) , PKCD (human) ( 364 ) , PKCE (human) ( 364 ) , PKCI (mouse) ( 435 ) , PKCT (mouse) ( 297 ) , PKR (mouse) ( 239 ) , PLCB2 (human) ( 159 ) , PPP2R5B (human) ( 205 ) , PPP2R5B (mouse) ( 264 ) , PSEN1 (mouse) ( 126 ) , PTEN (mouse) ( 94 , 103 , 109 , 113 , 114 , 189 , 248 , 269 , 275 , 356 , 359 ) , PTGER3 (mouse) ( 208 ) , PTGER4 (mouse) ( 222 ) , PYCARD (mouse) ( 194 ) , Raptor (mouse) ( 173 , 208 , 347 ) , RASAL2 (human) ( 41 ) , Rb (mouse) ( 115 ) , RBPJ (mouse) ( 118 ) , Ret (human) ( 286 ) , RHEB (mouse) ( 173 ) , RICTOR (human) ( 37 , 61 , 87 , 168 , 238 , 249 , 256 ) , RICTOR (mouse) ( 134 , 143 , 153 , 208 , 217 , 228 , 230 , 238 , 269 , 289 , 303 , 338 ) , ROCK1 (mouse) ( 259 ) , SCD (mouse) ( 389 ) , SGK1 (mouse) ( 132 ) , SH3BP2 (mouse) ( 332 ) , SHC1 (mouse) ( 328 ) , SHP-2 (human) ( 190 ) , SHP-2 (mouse) ( 250 , 444 ) , SIGLEC7 (mouse) ( 127 ) , SIK (human) ( 104 ) , Sin1 (human) ( 32 , 227 ) , Sin1 (mouse) ( 163 , 227 , 268 , 345 ) , SIRT1 (human) ( 168 ) , SIRT1 (mouse) ( 212 ) , SIRT7 (human) ( 31 ) , SIRT7 (mouse) ( 31 ) , SMO (mouse) ( 85 ) , SPHK1 (human) ( 203 ) , Src (human) ( 342 ) , SRR (human) ( 26 ) , STAT3 (human) ( 245 ) , Syk (mouse) ( 469 ) , syndecan-4 (mouse) ( 283 ) , TBK1 (human) ( 37 ) , TBK1 (mouse) ( 210 , 346 ) , TCL1A (mouse) ( 470 ) , TDGF1 (mouse) ( 176 ) , TMCC3 (human) ( 55 ) , TMEM55B (mouse) ( 260 ) , TNFAIP8 (human) ( 24 ) , TORC2 (mouse) ( 265 ) , TREM2 (mouse) ( 80 ) , TSC1 (mouse) ( 185 , 236 , 344 ) , TSC2 (mouse) ( 156 , 160 , 224 , 230 , 322 , 344 , 347 , 352 ) , TTC3 (human) ( 247 ) , VEGF (human) ( 141 ) , ZAP70 (human) ( 39 )
Putative in vivo kinases:
Akt1 (mouse) ( 473 ) , ILK (human) ( 423 ) , mTOR (human) ( 37 ) , P38A (mouse) ( 404 ) , PIK3C2A (human) ( 141 ) , PKCB (mouse) ( 394 )
Kinases, in vitro:
Akt1 (mouse) ( 473 ) , mTOR (human) ( 37 , 155 ) , mTOR (mouse) ( 143 , 368 ) , PKCA (mouse) ( 216 ) , TBK1 (human) ( 37 )
Putative upstream phosphatases:
PHLPP (mouse) ( 191 ) , PHLPP2 (mouse) ( 191 ) , PPP2CA (human) ( 56 , 205 ) , PTEN (mouse) ( 461 )
Treatments:
L-NPA ( 63 ) , #11a ( 35 ) , 1-butanol ( 380 ) , 4-HT ( 230 , 273 ) , 8,8'-bieckol ( 57 ) , 8-(3-chlorostyryl) caffeine ( 310 ) , 8-Rp-cAMP ( 321 ) , A-443654 ( 273 ) , acadesine ( 142 , 304 , 409 ) , acetic acid ( 66 ) , ACh ( 393 ) , actinomycin_D ( 439 ) , activin ( 433 ) , adiponectin ( 130 , 258 ) , ADP ( 49 ) , adriamycin ( 31 , 218 ) , AG1433 ( 428 ) , AG1478 ( 380 ) , Akt-I-1 ( 273 ) , Akt_activator_compound_11 ( 206 ) , Akt_inhibitor_VIII ( 133 , 159 , 163 , 164 , 179 , 273 ) , Akt_inhibitor_X ( 140 ) , alloxazine ( 310 ) , alpelisib ( 37 ) , alpha-lipoic_acid ( 195 ) , AM251 ( 193 ) , amino_acid_starvation ( 338 ) , amino_acids ( 37 , 160 , 226 , 245 , 344 ) , amlexanox ( 37 ) , angiopoietin-1 ( 383 ) , angiopoietin-2 ( 383 ) , angiotensin_2 ( 148 , 212 , 340 ) , anti-CD19 ( 16 ) , anti-CD3 ( 16 , 39 , 82 , 216 , 232 ) , anti-CD3/CD28 ( 101 , 114 , 132 , 207 , 232 , 278 , 299 , 341 ) , anti-CD4 ( 232 ) , anti-CTLA-4 ( 246 ) , anti-IgB ( 302 ) , anti-IgE ( 250 ) , anti-IgM ( 16 , 29 , 169 , 233 , 248 ) , anti-integrin_alpha9beta1 ( 151 ) , anti-ITGA4 ( 383 ) , anti-ITGA6 ( 383 ) , anti-ITGB1 ( 428 ) , anti-ITGB3 ( 383 ) , anti-kappa chain antibody ( 96 ) , anti-TCR ( 132 ) , anti-TNFalpha ( 194 ) , apyrase ( 49 ) , arsenite ( 430 ) , AS252424 ( 208 ) , atorvastatin ( 310 ) , axatomy ( 116 ) , AZD8055 ( 53 , 137 ) , bacterial infection ( 422 ) , BAPTA-AM ( 411 , 450 ) , BDNF ( 94 , 150 ) , BI-D1870 ( 246 ) , bicuculline ( 150 ) , bisindolylmaleimide ( 216 ) , blood pressure ( 340 ) , bromocriptine ( 416 ) , butaprost ( 208 ) , BX795 ( 37 , 66 , 268 ) , BX912 ( 66 ) , C3aR_antagonist ( 299 ) , C5aR_antagonist ( 299 ) , calphostin_C ( 164 ) , calyculin_A ( 364 ) , canertinib ( 296 ) , cangrelor ( 411 ) , carboplatin ( 20 ) , CAS_227449-73-2 ( 146 ) , castration ( 189 ) , catalase ( 453 ) , CC260 ( 44 ) , cell_adhesion ( 402 ) , CF3CN ( 35 ) , chronic unpredictable stress ( 52 ) , ciclopirox_olamine ( 192 ) , cilengitide ( 68 ) , cisplatin ( 137 ) , CL316,243 ( 48 ) , clodronic_acid ( 51 ) , clonidine ( 393 ) , cold_water_stress ( 323 ) , colforsin ( 222 , 382 , 463 ) , collagen ( 49 ) , Collagen related peptide ( 49 ) , ConA ( 272 ) , conditioned medium ( 29 ) , copanlisib ( 66 ) , cpd22 ( 81 ) , CRP ( 329 ) , culturing_of_cells ( 158 ) , CXCL12 ( 440 ) , CXCL5 ( 262 ) , cyclic_stretch ( 222 ) , cycloheximide ( 156 , 215 , 439 ) , cysteine ( 26 ) , dactolisib ( 134 , 189 ) , DEN ( 33 ) , deoxygenation ( 38 ) , development ( 360 ) , dexamethasone ( 155 , 237 ) , DI-PHPB ( 126 ) , dieckol ( 57 ) , DNP ( 469 ) , doconexent ( 441 ) , DPCPX ( 310 ) , Dynasore ( 169 ) , eckol ( 57 ) , EDTA ( 383 ) , EGF ( 31 , 37 , 94 , 181 , 196 , 219 , 244 , 260 , 261 , 300 , 335 , 345 , 364 , 380 , 427 , 432 , 443 , 444 , 445 , 463 , 468 , 472 ) , EGTA ( 380 , 414 ) , eplerenone ( 84 ) , Epo ( 243 ) , estradiol ( 321 , 361 , 367 , 462 ) , ethanol ( 448 ) , ether ( 323 ) , etoposide ( 137 ) , exercise ( 52 , 128 , 294 , 295 ) , exercise training ( 125 ) , faslodex ( 367 ) , fasting ( 31 , 76 , 122 , 154 , 205 , 212 , 242 ) , FGF2 ( 283 , 345 , 364 , 369 , 443 ) , fibrinogen ( 127 ) , fingolimod ( 131 ) , fluoxetine ( 52 ) , fMLP ( 159 ) , food deprivation ( 323 ) , fostriecin ( 374 ) , free_fatty_acids ( 17 ) , G-CSF ( 339 ) , GAB-001 ( 29 ) , GAB-004 ( 29 ) , GDNF ( 286 ) , gefitinib ( 41 , 342 ) , genistein ( 301 , 380 , 462 , 469 ) , GF109203X ( 364 , 411 ) , glucosamine ( 288 ) , glucose ( 197 , 209 , 222 , 224 , 230 , 277 , 288 , 328 ) , glucose_starvation ( 330 ) , glycine ( 150 ) , GM-CSF ( 257 , 306 ) , Go_6976 ( 164 , 216 , 283 , 364 ) , growth factor stimulation ( 26 ) , GSK2334470 ( 66 , 107 ) , guanosine ( 331 ) , H-89 ( 222 , 321 ) , H-CHO ( 175 ) , H2O2 ( 168 , 222 , 275 , 373 , 380 , 453 ) , haloperidol ( 413 ) , heating ( 42 ) , herstatin ( 443 ) , HGF ( 364 ) , high-fat diet ( 51 , 59 , 75 , 129 , 266 , 284 , 337 , 397 ) , high_glucose ( 203 ) , honokiol ( 186 ) , HU-210 ( 193 ) , hypertension ( 377 ) , hypoxia ( 59 ) , hypoxia/reoxygenation ( 197 ) , IBMX ( 69 , 160 , 222 , 382 ) , ibrutinib ( 29 ) , IC87114 ( 208 ) , ICAM-1 ( 351 ) , icatibant ( 340 , 377 ) , ifenprodil ( 72 ) , IFN-gamma ( 30 , 331 , 424 , 457 ) , IgE ( 394 , 469 ) , IGF-1 ( 120 , 227 , 281 , 283 , 326 , 344 , 356 , 364 , 365 , 366 , 396 , 407 , 414 , 432 , 436 , 454 , 456 , 462 , 467 , 472 ) , IGF-2 ( 364 , 366 , 436 ) , IGFBP-4 ( 436 ) , IL-10 ( 399 ) , IL-1b ( 194 ) , IL-2 ( 325 , 447 ) , IL-21 ( 319 ) , IL-3 ( 229 , 273 , 319 , 379 , 459 ) , IL-4 ( 417 ) , IL-6 ( 190 , 433 ) , IL-7 ( 70 , 124 , 325 ) , imatinib ( 229 , 442 ) , inflammation ( 285 ) , insulin ( 25 , 28 , 37 , 43 , 44 , 45 , 46 , 50 , 51 , 54 , 55 , 59 , 60 , 62 , 63 , 64 , 69 , 83 , 94 , 98 , 107 , 111 , 118 , 119 , 121 , 122 , 123 , 125 , 130 , 135 , 142 , 143 , 144 , 145 , 147 , 160 , 164 , 168 , 175 , 177 , 178 , 185 , 186 , 193 , 194 , 202 , 205 , 206 , 209 , 212 , 213 , 224 , 226 , 228 , 236 , 237 , 239 , 241 , 245 , 249 , 253 , 254 , 256 , 259 , 262 , 264 , 265 , 267 , 268 , 269 , 273 , 277 , 281 , 284 , 289 , 290 , 292 , 297 , 303 , 304 , 316 , 322 , 329 , 337 , 338 , 343 , 345 , 349 , 354 , 357 , 360 , 366 , 367 , 375 , 384 , 386 , 388 , 391 , 392 , 397 , 398 , 400 , 403 , 418 , 425 , 431 , 446 , 450 , 454 , 455 , 458 , 461 , 466 , 467 ) , ionizing_radiation ( 137 , 281 ) , ionomycin ( 472 ) , ischemia ( 38 , 251 , 452 ) , ischemia/reperfusion ( 298 , 434 , 452 ) , isoflurane ( 75 ) , isoproterenol ( 60 , 69 , 140 ) , JAK_inhibitor_I ( 141 ) , JNK_inhibitor_I ( 343 ) , ketamine ( 47 ) , KGF ( 364 ) , KirA6 ( 60 ) , KP-392 ( 449 ) , KU-0063794 ( 37 , 97 , 164 ) , L-mevalonate ( 43 ) , laminar flow ( 410 ) , latrunculin_A ( 96 ) , let-7 miRNA ( 178 ) , leucine ( 154 ) , levamfetamine ( 374 ) , LG268 ( 403 ) , LIF ( 395 ) , LIF withdrawal ( 99 ) , lithium ( 349 ) , long-term_potentiation ( 240 ) , low-fat diet ( 59 ) , low_glucose ( 31 ) , low_temperature ( 48 , 53 ) , LPA ( 24 ) , LPS ( 30 , 60 , 89 , 210 , 255 , 399 , 422 , 424 , 439 , 448 , 449 ) , LY294002 ( 30 , 47 , 57 , 68 , 98 , 106 , 107 , 141 , 145 , 146 , 163 , 164 , 179 , 206 , 210 , 244 , 246 , 255 , 273 , 278 , 286 , 293 , 301 , 304 , 337 , 338 , 348 , 353 , 356 , 374 , 380 , 393 , 395 , 396 , 399 , 402 , 404 , 405 , 410 , 411 , 414 , 415 , 420 , 424 , 437 , 442 , 447 , 452 , 459 , 464 , 467 , 469 ) , M-CSF ( 317 , 332 , 438 ) , magnetic_field,_coherent ( 71 ) , meal feeding ( 185 , 203 ) , mechanical stress ( 133 , 164 ) , memantine ( 363 ) , metamfetamine ( 72 ) , metformin ( 149 , 298 ) , methotrexate ( 427 ) , methyl-beta-cyclodextrin ( 184 ) , MG132 ( 161 ) , miR-143 ( 202 ) , miRNA ( 62 , 101 ) , MK-2206 ( 107 , 134 , 145 ) , MK801 ( 414 ) , MMS ( 352 ) , MPTP ( 361 ) , MRS-1523 ( 310 ) , mutation ( 163 ) , myocardial infarction ( 121 ) , myostatin ( 326 ) , N-cadherin ( 234 ) , NAC ( 168 , 453 ) , NBD_peptide ( 154 ) , nerve_damage ( 161 ) , neuregulin ( 65 ) , NGF ( 182 ) , Ni(2+) ( 214 ) , nicardipine ( 377 ) , nitric_oxide ( 405 ) , NKH_477 ( 160 ) , NP68 ( 246 ) , nutlin-3 ( 106 ) , NVP-BKM120 ( 66 , 83 , 134 ) , OGD/R ( 38 ) , okadaic_acid ( 205 , 304 , 342 , 364 , 374 , 378 , 456 ) , OVA ( 132 ) , PA ( 265 ) , palmitate ( 63 , 177 , 226 , 297 , 312 , 343 ) , PAN ( 215 ) , PAR1-activating_peptide ( 411 ) , PAR4-activating_peptide ( 411 ) , PD0325901 ( 41 ) , PD123319 ( 340 , 377 ) , PD98059 ( 98 ) , PDGF ( 24 , 37 , 241 , 271 , 318 , 320 , 321 , 344 , 345 , 428 , 464 , 465 , 467 ) , Pentadecanoic acid ( 64 ) , peptidoglycan ( 60 ) , PF 573228 ( 68 ) , PF-4708671 ( 163 ) , PGE2 ( 208 , 222 ) , PHA-665752 ( 68 ) , phentolamine ( 204 ) , phorbol_ester ( 159 , 364 , 411 , 472 ) , physostigmine ( 363 ) , PI-103 ( 299 ) , picropodophyllin ( 396 ) , pictilisib ( 66 ) , PIF ( 301 ) , PIK90 ( 268 ) , pilocarpine ( 363 ) , PIP3 ( 67 ) , pleiotrophin ( 305 ) , poly(I-C) ( 37 , 210 ) , PP1 ( 16 ) , PP2 ( 16 , 146 , 407 ) , PP242 ( 132 , 235 , 268 ) , pregnancy ( 327 ) , pressure ( 279 ) , PTX ( 208 ) , RAD001 ( 287 ) , RANKL ( 381 ) , rapamycin ( 44 , 115 , 120 , 137 , 163 , 164 , 178 , 185 , 208 , 218 , 224 , 226 , 227 , 235 , 236 , 238 , 245 , 246 , 254 , 268 , 273 , 283 , 289 , 304 , 308 , 334 , 337 , 338 , 344 , 349 , 352 , 365 , 375 , 384 ) , refeeding ( 122 , 205 , 242 ) , resveratrol ( 168 ) , RGD ( 383 ) , RGE ( 383 ) , rigosertib ( 34 ) , rosiglitazone ( 186 , 350 , 403 ) , rottlerin ( 364 ) , SB202190 ( 335 ) , SB203580 ( 63 , 218 , 404 ) , SCF ( 282 , 348 , 420 ) , serum ( 32 , 37 , 133 , 178 , 217 , 220 , 231 , 238 , 269 , 338 , 344 , 345 , 347 , 364 , 373 , 437 , 472 ) , serum_starvation ( 94 , 154 , 178 , 269 , 338 ) , serum_withdrawal ( 404 ) , Shh ( 293 ) , SHP099 ( 51 ) , simvastatin ( 43 ) , siRNA ( 29 , 191 , 264 , 289 , 300 , 316 , 343 , 347 , 357 , 392 ) , skin aging ( 86 ) , SN-50 ( 439 ) , SP600125 ( 367 , 407 ) , sphingomyelinase ( 92 , 203 ) , sphingosine_1-phosphate ( 113 ) , SPT ( 310 ) , starvation_medium ( 154 ) , staurosporine ( 441 ) , streptozotocin ( 75 ) , SU5402 ( 353 ) , SU6656 ( 342 ) , sulforaphane ( 333 ) , sulprostone ( 208 ) , sVCAM-1 ( 351 ) , t-butanol ( 380 ) , tamoxifen ( 313 ) , TGF-alpha ( 443 ) , TGF-beta ( 101 , 422 , 433 , 468 ) , thapsigargin ( 60 , 179 ) , Theophylline ( 310 ) , thrombin ( 174 , 411 ) , TNF ( 33 , 60 , 194 , 331 , 352 , 357 , 367 , 439 , 456 , 471 ) , topotecan ( 137 ) , Torin1 ( 37 , 107 , 208 , 215 ) , TPCK ( 439 ) , triciribine ( 195 ) , troglitazone ( 355 , 365 ) , TUG-891 ( 93 ) , tunicamycin ( 276 ) , U0126 ( 88 , 224 , 246 , 273 , 310 , 315 , 337 , 349 , 353 , 373 , 382 , 445 ) , UV ( 390 , 435 , 453 ) , UVB ( 86 ) , vanadate ( 157 , 222 ) , VAT-R ( 50 ) , VEGF ( 283 , 412 ) , vemurafenib ( 19 ) , VIIa ( 213 ) , Visudyne ( 24 ) , vitronectin ( 383 ) , VPS34-IN1 ( 66 ) , WIN ( 415 ) , Wnt ( 349 , 436 ) , Wnt3a ( 349 ) , wortmannin ( 38 , 69 , 80 , 94 , 119 , 163 , 195 , 208 , 224 , 226 , 236 , 246 , 254 , 278 , 289 , 315 , 326 , 337 , 344 , 349 , 351 , 362 , 365 , 375 , 388 , 391 , 399 , 402 , 428 , 437 , 439 , 442 , 456 , 464 , 465 , 467 , 469 , 470 ) , XL-147 ( 79 ) , YM-254890 ( 93 )

Downstream Regulation
Effects of modification on Akt1:
acetylation ( 61 ) , activity, induced ( 133 , 140 ) , enzymatic activity, induced ( 14 , 56 , 57 , 124 , 155 , 158 , 168 , 172 , 173 , 209 , 261 , 275 , 288 , 404 , 411 , 414 , 430 , 442 , 443 , 469 ) , intracellular localization ( 61 , 168 , 450 , 462 ) , molecular association, regulation ( 167 , 205 ) , phosphorylation ( 35 , 57 , 61 , 155 , 164 , 205 , 212 ) , protein degradation ( 167 ) , ubiquitination ( 167 )
Effects of modification on biological processes:
apoptosis, altered ( 158 , 223 , 275 ) , apoptosis, inhibited ( 14 , 29 , 30 , 38 , 134 , 155 , 260 ) , autophagy, inhibited ( 15 ) , carcinogenesis, altered ( 24 ) , carcinogenesis, induced ( 33 , 34 , 36 , 55 , 56 , 58 , 68 , 102 , 134 , 151 ) , cell cycle regulation ( 134 , 311 ) , cell differentiation, induced ( 17 , 36 , 173 ) , cell growth, altered ( 260 , 451 ) , cell growth, induced ( 14 , 26 , 33 , 36 , 43 , 56 , 58 , 65 , 71 , 134 , 184 ) , cell growth, inhibited ( 24 ) , cell motility, induced ( 24 , 29 , 40 , 55 , 151 ) , cytoskeletal reorganization ( 260 ) , neural plasticity ( 158 ) , RNA splicing, induced ( 82 ) , signaling pathway regulation ( 66 , 68 , 75 , 139 , 140 , 141 , 144 , 158 , 173 , 191 , 228 , 283 ) , transcription, altered ( 36 , 50 ) , transcription, induced ( 469 ) , transcription, inhibited ( 15 , 53 , 155 , 168 ) , translation, induced ( 20 ) , translation, inhibited ( 155 )
Induce interaction with:
CHIP (human) ( 167 ) , PPP2CA (human) ( 205 ) , PPP2R5B (mouse) ( 205 )

Disease / Diagnostics Relevance
Relevant diseases:
endometrial cancer ( 359 ) , melanoma skin cancer ( 103 ) , type 2 diabetes ( 337 , 350 , 406 ) , Turner-like syndrome ( 51 )

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