Ser473
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Site Information
RPHFPQFsysAsGtA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447855
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 365 , 376 ) , flow cytometry ( 16 , 167 , 169 ) , immunoprecipitation ( 7 , 12 , 16 , 17 , 35 , 54 , 64 , 79 , 89 , 141 , 180 , 184 , 196 , 211 , 395 , 396 ) , mass spectrometry ( 7 , 18 , 21 , 31 , 67 , 74 , 237 ) , mass spectrometry (in vitro) ( 64 , 133 ) , microscopy-colocalization with upstream kinase ( 210 ) , mutation of modification site ( 17 , 64 , 89 , 105 , 146 , 186 , 199 , 201 , 245 , 253 , 282 , 317 , 319 , 327 , 333 , 365 , 376 , 379 , 383 , 396 ) , peptide sequencing ( 158 , 320 ) , phospho-antibody ( 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 27 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 54 , 57 , 64 , 65 , 68 , 72 , 78 , 79 , 80 , 83 , 84 , 87 , 89 , 93 , 100 , 101 , 102 , 103 , 104 , 105 , 108 , 109 , 112 , 115 , 116 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 127 , 129 , 130 , 131 , 133 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 149 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 201 , 202 , 203 , 204 , 207 , 208 , 209 , 210 , 211 , 212 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 231 , 232 , 233 , 234 , 235 , 236 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 253 , 254 , 255 , 256 , 257 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 290 , 291 , 292 , 293 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 350 , 351 , 352 , 353 , 354 , 355 , 356 , 357 , 359 , 360 , 361 , 362 , 363 , 364 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 372 , 373 , 374 , 375 , 377 , 378 , 379 , 380 , 381 , 382 , 383 , 384 , 385 , 386 , 387 , 388 , 389 , 390 , 391 , 392 , 393 , 394 , 395 , 396 ) , western blotting ( 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 27 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 54 , 57 , 64 , 65 , 68 , 72 , 78 , 79 , 80 , 83 , 84 , 87 , 89 , 93 , 100 , 101 , 102 , 103 , 104 , 105 , 108 , 109 , 112 , 115 , 116 , 118 , 119 , 120 , 121 , 123 , 124 , 125 , 127 , 129 , 130 , 131 , 133 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 149 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 201 , 202 , 203 , 204 , 207 , 208 , 209 , 210 , 211 , 212 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 231 , 232 , 233 , 234 , 235 , 236 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 253 , 254 , 255 , 256 , 257 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 278 , 279 , 282 , 283 , 285 , 286 , 287 , 288 , 290 , 296 , 300 , 306 , 307 , 310 , 312 , 313 , 314 , 315 , 318 , 319 , 320 , 322 , 323 , 324 , 326 , 327 , 329 , 332 , 333 , 336 , 338 , 339 , 343 , 345 , 346 , 350 , 351 , 354 , 356 , 357 , 359 , 360 , 361 , 362 , 364 , 368 , 369 , 370 , 372 , 373 , 374 , 375 , 378 , 379 , 382 , 385 , 389 , 391 , 392 , 393 , 394 , 395 , 396 )
Disease tissue studied:
Alzheimer's disease ( 4 , 105 ) , bone cancer ( 103 ) , brain cancer ( 186 , 198 ) , glioblastoma ( 186 , 198 ) , glioma ( 186 , 198 ) , breast cancer ( 7 , 15 , 181 , 197 , 203 , 244 , 391 ) , cervical cancer ( 360 ) , cervical adenocarcinoma ( 360 ) , colorectal cancer ( 103 , 146 , 245 , 345 ) , colorectal carcinoma ( 103 , 146 , 245 , 345 ) , endometrial cancer ( 282 ) , endometrial adenocarcinoma ( 282 ) , liver cancer ( 26 , 168 , 199 ) , hepatocellular carcinoma ( 26 ) , lung cancer ( 146 , 231 , 265 , 310 ) , mesothelioma ( 310 ) , non-small cell lung cancer ( 146 , 231 ) , lymphoma ( 308 , 363 ) , B cell lymphoma ( 363 ) , T cell lymphoma ( 308 ) , neuroblastoma ( 18 , 36 , 118 , 338 , 364 ) , ovarian cancer ( 256 ) , pancreatic cancer ( 122 , 146 , 211 ) , pancreatic carcinoma ( 146 , 211 ) , multiple myeloma ( 79 , 356 ) , prostate cancer ( 143 , 193 ) , melanoma skin cancer ( 319 ) , fibrosarcoma of soft tissue ( 356 , 379 ) , diabetes mellitus ( 203 , 273 ) , type 2 diabetes ( 162 , 203 , 273 ) , Huntington's disease ( 54 ) , Lafora disease ( 175 ) , Duchenne muscular dystrophy ( 8 ) , schizophrenia ( 336 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 31 , 67 ) , 'brain, cerebral cortex' ( 157 , 286 , 329 , 336 , 375 ) , 'brain, embryonic' ( 237 ) , 'brain, embryonic' [BAG1 (mouse)] ( 294 ) , 'brain, hippocampus' ( 163 , 246 , 286 ) , 'brain, hippocampus' [APP (human), genetic knockin] ( 105 ) , 'brain, nucleus accumbens' ( 19 ) , 'brain, striatum' ( 54 , 286 , 297 , 337 ) , 'fat, brown'-'fat, brown' ( 127 ) , 'liver, fetal' ( 276 ) , 'muscle, skeletal' ( 1 , 64 , 116 , 182 , 185 , 190 , 207 , 215 , 217 , 218 , 260 , 309 , 323 , 326 , 342 ) , 'muscle, skeletal' [APPL (human), homozygous knockout] ( 47 ) , 'muscle, skeletal' [DNAPK (mouse), homozygous knockout] ( 204 ) , 'muscle, skeletal' [genetic knockin] ( 47 ) , 'muscle, skeletal' [RICTOR (mouse), homozygous knockout] ( 179 , 226 ) , 'neuron, cortical' ( 80 , 174 , 227 ) , 'neuron, cortical'-brain ( 18 , 72 , 299 ) , 'neuron, cortical'-brain [NYAP2 (mouse), homozygous knockout] ( 84 ) , 'neuron, hippocampal' ( 80 ) , 'neuron, striatal'-brain ( 284 ) , 'neuron, superior cervical ganglion' ( 209 ) , 'renal, podocyte' ( 145 ) , 'stem, embryonic' ( 215 ) , 293 (epithelial) ( 12 , 140 , 161 , 186 , 197 , 232 , 288 , 299 , 301 , 348 , 396 ) , 293E (epithelial) ( 245 ) , 293T (epithelial) ( 17 , 46 , 64 , 72 , 133 , 180 , 245 , 393 ) , 32D (myeloid) ( 124 ) , 3T3 (fibroblast) ( 100 , 129 , 149 , 170 , 184 , 187 , 196 , 231 , 244 , 296 , 360 , 361 , 373 , 374 ) , 3T3 (fibroblast) [INSR (human)] ( 260 ) , 3T3 (fibroblast) [INSR (mouse), transfection] ( 196 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 298 , 307 , 310 , 314 , 317 , 354 , 359 , 362 , 367 , 378 , 384 , 386 , 387 , 388 ) , 3T3 (fibroblast) [Src (human)] ( 265 ) , 3T3-L1 (fibroblast) ( 109 , 159 , 160 , 164 , 212 , 239 , 241 , 253 , 260 , 273 , 290 , 369 ) , 4T1 (breast cell) ( 181 , 391 ) , A431 (epithelial) ( 146 ) , A549 (pulmonary) ( 146 , 231 ) , adipocyte ( 257 ) , adipocyte [F2RL1 (mouse), homozygous knockout] ( 136 ) , adipocyte [N-CoR1 (mouse), homozygous knockout] ( 87 ) , adipocyte-adipose tissue [N-CoR1 (mouse), homozygous knockout] ( 87 ) , adipose tissue ( 215 , 260 , 312 , 321 ) , adipose tissue [DNAPK (mouse), homozygous knockout] ( 204 ) , adipose tissue [F2RL1 (mouse), homozygous knockout] ( 136 ) , adipose tissue [p70S6K (mouse), homozygous knockout] ( 320 ) , adipose tissue [RICTOR (mouse), homozygous knockout] ( 179 ) , AE7 ( 248 ) , alphaT3-1 (pituitary cell) ( 57 ) , aorta ( 247 ) , artery ( 220 ) , astrocyte-'brain, striatum' ( 328 ) , AV12 ('neuron, neostriatal') ( 324 ) , B lymphocyte ( 274 ) , B lymphocyte [BCAP (mouse), homozygous knockout] ( 225 ) , B lymphocyte [CD19 (mouse), homozygous knockout] ( 225 ) , B lymphocyte-spleen ( 156 ) , B lymphocyte-spleen [PTEN (mouse), transgenic] ( 171 ) , B9 (fibroblast) ( 356 ) , BAEC (endothelial) ( 292 ) , BaF3 ('B lymphocyte, precursor') ( 68 , 152 , 166 , 196 , 238 , 242 , 262 , 301 , 331 , 382 ) , BaF3 ('B lymphocyte, precursor') [EGFR (human)] ( 265 ) , BALB/MK (keratinocyte) ( 395 ) , BE (melanocyte) ( 319 ) , beta TC3 (pancreatic) ( 211 ) , beta-pancreas ( 266 ) , beta-pancreas [INSR (mouse), transgenic] ( 147 ) , BLMVEC (endothelial) ( 333 ) , BMMC (mast) ( 131 , 392 ) , bone marrow ( 262 , 322 ) , brain ( 74 , 219 , 279 ) , brain [CDK5R1 (mouse)] ( 219 ) , brain [laforin (mouse), homozygous knockout] ( 175 ) , brain [NYAP2 (mouse), homozygous knockout] ( 84 ) , breast [PDK1 (mouse), homozygous knockout] ( 15 ) , breast cell ( 7 ) , C141 (epidermal) ( 376 ) , C2C12 (myoblast) ( 22 , 176 , 224 , 228 , 236 , 249 , 306 , 390 ) , C2C12 (myoblast) [LIN28A (mouse), transfection] ( 101 ) , C3H10T1/2 (fibroblast) ( 216 ) , Calu-1 (squamous) ( 231 ) , CEF ( 383 ) , CHO (fibroblast) ( 17 , 389 ) , CHO (fibroblast) [Tau iso8 (human)] ( 278 ) , CMT-93 (intestinal) ( 345 ) , colon ( 5 ) , COS (fibroblast) ( 68 , 175 , 196 , 301 , 352 , 365 ) , CTL-EN (T lymphocyte) ( 229 ) , CTLL-2 (T lymphocyte) ( 370 ) , diaphragm ( 8 ) , DLD1 (intestinal) ( 146 ) , DU 145 (prostate cell) ( 193 ) , E14tg2a ('stem, embryonic') ( 23 , 318 ) , embryo ( 74 , 276 ) , epithelial ( 210 ) , epithelial-lens ( 243 ) , ES (stem) ( 33 ) , F9 (testicular) ( 365 ) , Fao (hepatic) ( 199 ) , FDCP-1 (myeloid) ( 302 ) , fibroblast ( 9 ) , fibroblast-embryo [BAG1 (mouse)] ( 294 ) , G361 (melanocyte) ( 355 ) , GD25 (fibroblast) ( 325 , 351 ) , GT1-7 (neuron) ( 277 ) , H9c2 (myoblast) ( 260 ) , HaCaT (keratinocyte) ( 10 ) , HCCLM3 (hepatic) ( 26 ) , HCT116 (intestinal) ( 103 ) , HCT15 (intestinal) ( 146 ) , heart ( 45 , 144 , 215 , 221 , 233 , 260 , 283 , 341 ) , heart [AMPKA2 (mouse), homozygous knockout] ( 202 ) , heart [DNAPK (human), transfection] ( 204 ) , HeLa (cervical) ( 65 , 89 , 103 , 123 , 140 , 146 , 197 , 245 , 301 , 320 ) , HeLa S3 (cervical) ( 360 ) , hepatocyte ( 168 ) , hepatocyte-liver ( 189 , 266 ) , hepatocyte-liver [eIF2-alpha (mouse), homozygous knockout] ( 199 ) , hepatocyte-liver [TSC1 (mouse), homozygous knockout] ( 108 ) , HepG2 (hepatic) ( 168 , 396 ) , HT-29 (intestinal) ( 245 ) , HUVEC (endothelial) ( 257 ) , IC2 (mast) ( 343 ) , intestine ( 24 ) , Ishikawa (endometrial) ( 282 ) , J558L (B lymphocyte) ( 79 ) , J774 (macrophage) ( 372 ) , JB (epithelial) ( 313 , 353 ) , Jurkat (T lymphocyte) ( 201 ) , keratinocyte ( 287 ) , keratinocyte-skin ( 281 , 285 ) , keratinocyte-skin [IGF1 (mouse)] ( 288 ) , L6 (myoblast) ( 149 ) , liver ( 74 , 125 , 165 , 195 , 203 , 215 , 260 , 323 , 371 ) , liver [DNAPK (mouse), homozygous knockout] ( 204 ) , liver [p70S6K (mouse), homozygous knockout] ( 320 ) , liver [RICTOR (mouse), homozygous knockout] ( 179 ) , lung ( 309 ) , lymphocyte ( 16 , 21 , 336 ) , lymphocyte-spleen ( 6 , 20 , 25 ) , lymphocyte-spleen [p53 (mouse), transfection] ( 208 ) , M059J (glial) ( 186 , 234 ) , M2-10B4 ( 34 ) , macrophage-bone marrow ( 4 , 13 , 30 , 240 , 255 , 346 ) , macrophage-peritoneum ( 178 ) , mammary gland ( 11 ) , mast-bone marrow ( 29 , 271 , 317 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 173 ) , MCF-7 (breast cell) ( 197 , 244 ) , MDA-MB-453 (breast cell) ( 203 ) , MEF (fibroblast) ( 12 , 65 , 78 , 121 , 123 , 137 , 138 , 141 , 153 , 154 , 159 , 161 , 172 , 185 , 186 , 192 , 198 , 214 , 216 , 231 , 234 , 235 , 245 , 253 , 259 , 261 , 267 , 268 , 269 , 270 , 272 , 275 , 350 ) , MEF (fibroblast) [Akt1 (mouse), heterozygous knockout] ( 167 ) , MEF (fibroblast) [Akt1 (mouse), homozygous knockout] ( 102 ) , MEF (fibroblast) [Akt2 (mouse), homozygous knockout] ( 167 ) , MEF (fibroblast) [BAG4 (mouse), homozygous knockout] ( 104 ) , MEF (fibroblast) [DNAPK (mouse), homozygous knockout] ( 204 ) , MEF (fibroblast) [EIF4E (mouse), genetic knockin] ( 143 ) , MEF (fibroblast) [GADD34 (human)] ( 232 ) , MEF (fibroblast) [IGF1R (mouse)] ( 293 , 305 , 315 ) , MEF (fibroblast) [LKB1 (mouse)] ( 332 ) , MEF (fibroblast) [mTOR (mouse), homozygous knockout] ( 197 ) , MEF (fibroblast) [NRas (mouse), homozygous knockout] ( 394 ) , MEF (fibroblast) [PDGFRA (mouse), genetic knockin] ( 194 ) , MEF (fibroblast) [PKR (mouse), homozygous knockout] ( 162 ) , MEF (fibroblast) [RICTOR (human), homozygous knockout] ( 140 ) , MEF (fibroblast) [Sin1 (mouse), homozygous knockout] ( 150 , 191 ) , MEF (fibroblast) [TMEM55B (mouse), homozygous knockout] ( 183 ) , MES (pulmonary) ( 310 ) , MHCC97-L (hepatic) ( 26 ) , MIA PaCa-2 (pancreatic) ( 146 ) , microglia ( 254 ) , mIMCD-3 (epithelial) ( 368 ) , mLEC (epithelial) ( 115 ) , MMC (mesangial) ( 251 ) , MMTV-PyMT (breast cell) [JNK2 (mouse), homozygous knockout] ( 119 ) , MPC-11 (B lymphocyte) ( 356 ) , MS1 (endothelial) ( 306 ) , muscle ( 273 ) , muscle [laforin (mouse), homozygous knockout] ( 175 ) , muscle [p70S6K (mouse), homozygous knockout] ( 320 ) , MVT-1 (epithelial) ( 7 ) , myeloid ( 255 ) , myoblast ( 218 , 327 ) , myocyte-heart ( 44 , 120 , 228 , 250 , 385 ) , N1E-115 (neuron) ( 18 , 338 ) , NCI-H1299 (pulmonary) ( 146 ) , NCI-H157 (pulmonary) ( 231 ) , Neuro-2a (neuron) ( 36 , 118 , 364 ) , neuron-'brain, cerebral cortex' ( 357 ) , neuron-'brain, cerebral cortex' [STAT1 (mouse), homozygous knockout] ( 357 ) , neuron-'brain, hippocampus' ( 36 ) , neuron-dorsal root ganglia ( 83 ) , neutrophil ( 50 ) , NMuMG (epithelial) ( 35 , 391 ) , osteoclast ( 255 ) , ovarian ( 256 ) , pancreatic ( 122 ) , PaTu (pancreatic) ( 146 ) , PC-12 (chromaffin) ( 303 ) , PC3 (prostate cell) ( 193 ) , penis ( 335 ) , platelet-blood ( 2 , 334 ) , preadipocyte ( 257 ) , preosteoclast ( 304 ) , prostate ( 167 , 210 ) , prostate [homozygous knockout] ( 112 ) , Rat1 (fibroblast) ( 234 , 272 ) , RAW 264 (macrophage) ( 347 ) , RAW 264.7 (macrophage) ( 133 ) , RIE (epithelial) ( 272 ) , SCC16-5 (fibroblast) ( 380 ) , sertoli-testis ( 14 ) , SF9 ( 384 ) , skin ( 10 ) , SKOV-3 (ovarian) ( 256 ) , SN4741 (neuron) ( 339 ) , spleen ( 322 ) , SV40 ( 377 ) , SYF (fibroblast) ( 142 ) , T lymphocyte-blood ( 340 ) , T lymphocyte-lymph node ( 169 ) , T lymphocyte-lymph node [PKCT (mouse), homozygous knockout] ( 139 ) , T lymphocyte-spleen ( 130 , 222 , 248 , 264 ) , T lymphocyte-spleen [PKCT (mouse), homozygous knockout] ( 139 ) , T lymphocyte-thymus ( 308 ) , thoracic aorta ( 263 , 300 ) , thymocyte ( 158 ) , thymocyte [CBL (mouse), homozygous knockout] ( 155 ) , thyroid [Akt1 (mouse), homozygous knockout] ( 93 ) , U251 (glial) ( 198 ) , U2OS (bone cell) ( 103 ) , U2OS (bone cell) [GR (human)] ( 301 ) , uterus ( 282 , 295 ) , VSMC-aorta ( 316 ) , WEHI-164 (fibroblast) ( 379 ) , WEHI-231 (B lymphocyte) ( 363 )

Upstream Regulation
Regulatory protein:
14-3-3 zeta (mouse) ( 180 ) , ACVR2B (mouse) ( 249 ) , ADRB1 (mouse) ( 127 ) , Akt1 (human) ( 210 ) , Akt1 (mouse) ( 27 , 93 , 232 , 392 ) , Akt2 (mouse) ( 158 ) , ALK (human) ( 152 ) , AMPKA2 (mouse) ( 202 ) , APPL2 (human) ( 47 ) , ATF6A (mouse) ( 199 ) , BAFF (mouse) ( 274 ) , BAG1 (mouse) ( 294 ) , BAG4 (mouse) ( 104 ) , BCAP (mouse) ( 225 ) , BCR-ABL1 (human) ( 265 ) , BRCA1 (human) ( 110 ) , Brk (human) ( 142 ) , Btk (mouse) ( 392 ) , C3aR (mouse) ( 222 ) , C5aR (mouse) ( 222 ) , CBL (mouse) ( 155 ) , CD151 (mouse) ( 29 ) , CD19 (mouse) ( 225 ) , CDC42 iso1 (mouse) ( 285 ) , CDH2 (mouse) ( 157 ) , CDK5 (mouse) ( 219 ) , CDK5R1 (mouse) ( 219 ) , DICER1 (mouse) ( 25 ) , DNAPK (mouse) ( 186 , 204 ) , EIF4E (mouse) ( 143 ) , ERK5 (human) ( 333 ) , F2RL1 (mouse) ( 136 ) , FGFR1 (human) ( 238 ) , FOXO1A (human) ( 153 ) , FOXO1A (mouse) ( 153 , 257 ) , Fyn (mouse) ( 169 ) , GAB2 (mouse) ( 271 ) , GADD34 (human) ( 232 ) , GCN2 (mouse) ( 102 ) , GLRX1 (mouse) ( 243 ) , GPM6A (human) ( 36 ) , GPX1 (mouse) ( 323 ) , GRB10 (human) ( 68 ) , GRB10 (mouse) ( 32 ) , Huntingtin (mouse) ( 337 ) , ICMT (mouse) ( 350 ) , IFI16 (mouse) ( 223 ) , IGF1R (mouse) ( 249 , 330 ) , IKKA (mouse) ( 274 ) , IKKG (mouse) ( 280 ) , ILK (mouse) ( 5 , 218 ) , IRS1 (human) ( 266 ) , IRS1 (mouse) ( 266 ) , IRS2 (mouse) ( 266 ) , ITGA9 (human) ( 262 ) , ITGB1 (human) ( 351 ) , ITGB1 (mouse) ( 190 ) , JAK2 (mouse) ( 382 ) , JIP1 (mouse) ( 321 ) , JNK1 (mouse) ( 120 ) , JNK2 (mouse) ( 119 ) , K17 (mouse) ( 281 ) , KRas (mouse) ( 269 , 395 ) , LAB (mouse) ( 264 ) , laforin (mouse) ( 175 ) , LAMTOR1 (human) ( 154 ) , LAMTOR2 (mouse) ( 154 ) , LIMS1 (human) ( 146 ) , LIMS1 (mouse) ( 146 ) , LIN28A (mouse) ( 101 ) , LIN28B (mouse) ( 101 ) , LKB1 (mouse) ( 217 ) , LPIN1 (mouse) ( 188 ) , LST8 (mouse) ( 261 ) , LYN (mouse) ( 392 ) , MEK5 (human) ( 333 ) , Mnk1 (mouse) ( 231 ) , Mnk2 (mouse) ( 231 ) , MT1 (mouse) ( 283 ) , mTOR (mouse) ( 14 ) , Musashi-1 (mouse) ( 24 ) , MYD88 (human) ( 178 ) , N-CoR1 (mouse) ( 87 ) , NF1 (mouse) ( 259 ) , NFkB-p100 (mouse) ( 12 ) , NPM1 (human) ( 152 ) , NRas (mouse) ( 394 ) , NYAP2 (mouse) ( 84 ) , P38A (mouse) ( 141 ) , p53 (mouse) ( 39 ) , PAG (rat) ( 214 ) , PDGFRA (mouse) ( 194 ) , PDK1 (mouse) ( 15 , 215 ) , PERK (mouse) ( 102 ) , PGGT1B (mouse) ( 13 ) , PHB (human) ( 176 ) , PIK3C2A (mouse) ( 369 ) , PIKFYVE (human) ( 64 ) , PIKFYVE (mouse) ( 64 ) , Pim1 (human) ( 193 ) , PKCA (human) ( 139 , 287 ) , PKCD (human) ( 287 ) , PKCE (human) ( 287 ) , PKCI (mouse) ( 358 ) , PKCT (mouse) ( 220 ) , PKR (mouse) ( 162 ) , PPP2R5B (mouse) ( 187 ) , PTEN (mouse) ( 18 , 27 , 33 , 37 , 38 , 112 , 171 , 192 , 198 , 279 , 282 ) , PTGER3 (mouse) ( 131 ) , PTGER4 (mouse) ( 145 ) , Raptor (mouse) ( 131 , 270 ) , Rb (mouse) ( 39 ) , RBPJ (mouse) ( 42 ) , Ret (human) ( 209 ) , RICTOR (human) ( 11 , 161 , 172 , 179 ) , RICTOR (mouse) ( 65 , 131 , 140 , 153 , 161 , 192 , 212 , 226 , 261 ) , ROCK1 (mouse) ( 182 ) , SCD (mouse) ( 312 ) , SH3BP2 (mouse) ( 255 ) , SHC1 (mouse) ( 251 ) , SHP-2 (mouse) ( 173 , 367 ) , SIGLEC7 (mouse) ( 50 ) , Sin1 (human) ( 150 ) , Sin1 (mouse) ( 150 , 191 , 268 ) , SMO (mouse) ( 9 ) , Src (human) ( 265 ) , STAT3 (human) ( 168 ) , Syk (mouse) ( 392 ) , TBK1 (mouse) ( 133 , 269 ) , TCL1A (mouse) ( 393 ) , TMEM55B (mouse) ( 183 ) , TORC2 (mouse) ( 188 ) , TREM2 (mouse) ( 4 ) , TSC1 (mouse) ( 108 , 159 , 267 ) , TSC2 (mouse) ( 78 , 147 , 153 , 245 , 267 , 270 , 275 ) , TTC3 (human) ( 170 )
Putative in vivo kinases:
Akt1 (mouse) ( 396 ) , ILK (human) ( 346 ) , P38A (mouse) ( 327 ) , PKCB (mouse) ( 317 )
Kinases, in vitro:
Akt1 (mouse) ( 396 ) , mTOR (mouse) ( 65 , 291 ) , PKCA (mouse) ( 139 )
Putative upstream phosphatases:
PTEN (mouse) ( 384 )
Treatments:
1-butanol ( 303 ) , 4-HT ( 153 , 196 ) , 8-(3-chlorostyryl) caffeine ( 233 ) , 8-Rp-cAMP ( 244 ) , A-443654 ( 196 ) , acadesine ( 64 , 227 , 332 ) , ACh ( 316 ) , actinomycin_D ( 362 ) , activin ( 356 ) , adiponectin ( 181 ) , adriamycin ( 141 ) , AG1433 ( 351 ) , AG1478 ( 303 ) , Akt-I-1 ( 196 ) , Akt_activator_compound_11 ( 129 ) , Akt_inhibitor_VIII ( 102 , 196 ) , alloxazine ( 233 ) , alpha-lipoic_acid ( 118 ) , AM251 ( 116 ) , amino_acid_starvation ( 261 ) , amino_acids ( 149 , 168 , 267 ) , angiopoietin-1 ( 306 ) , angiopoietin-2 ( 306 ) , angiotensin_2 ( 263 ) , anti-CD3 ( 6 , 139 , 155 ) , anti-CD3/CD28 ( 25 , 38 , 130 , 155 , 201 , 222 , 264 ) , anti-CD4 ( 155 ) , anti-CTLA-4 ( 169 ) , anti-IgB ( 225 ) , anti-IgE ( 173 ) , anti-IgM ( 156 , 171 ) , anti-ITGA4 ( 306 ) , anti-ITGA6 ( 306 ) , anti-ITGB1 ( 351 ) , anti-ITGB3 ( 306 ) , anti-kappa chain antibody ( 20 ) , arsenite ( 353 ) , AS252424 ( 131 ) , atorvastatin ( 233 ) , axatomy ( 40 ) , bacterial infection ( 345 ) , BAPTA-AM ( 334 , 373 ) , BDNF ( 18 , 72 ) , BI-D1870 ( 169 ) , bicuculline ( 72 ) , bisindolylmaleimide ( 139 ) , blood pressure ( 263 ) , bromocriptine ( 339 ) , butaprost ( 131 ) , BX795 ( 191 ) , C3aR_antagonist ( 222 ) , C5aR_antagonist ( 222 ) , calphostin_C ( 86 ) , calyculin_A ( 287 ) , canertinib ( 219 ) , cangrelor ( 334 ) , CAS_227449-73-2 ( 68 ) , castration ( 112 ) , catalase ( 376 ) , cell_adhesion ( 325 ) , ciclopirox_olamine ( 115 ) , clonidine ( 316 ) , cold_water_stress ( 246 ) , colforsin ( 145 , 305 , 386 ) , ConA ( 195 ) , cpd22 ( 5 ) , CRP ( 252 ) , culturing_of_cells ( 80 ) , CXCL12 ( 363 ) , CXCL5 ( 185 ) , cyclic_stretch ( 145 ) , cycloheximide ( 78 , 138 , 362 ) , dactolisib ( 56 , 112 ) , development ( 283 ) , dexamethasone ( 160 ) , DNP ( 392 ) , doconexent ( 364 ) , DPCPX ( 233 ) , EDTA ( 306 ) , EGF ( 18 , 104 , 119 , 142 , 167 , 183 , 184 , 223 , 258 , 268 , 287 , 303 , 350 , 355 , 366 , 367 , 368 , 386 , 391 , 395 ) , EGTA ( 303 , 337 ) , eplerenone ( 8 ) , Epo ( 166 ) , estradiol ( 244 , 284 , 290 , 385 ) , ethanol ( 371 ) , ether ( 246 ) , exercise ( 217 , 218 ) , faslodex ( 290 ) , fasting ( 1 , 46 , 165 ) , FGF1 ( 206 ) , FGF2 ( 206 , 268 , 287 , 292 , 366 ) , fibrinogen ( 50 ) , fingolimod ( 54 ) , food deprivation ( 246 ) , fostriecin ( 297 ) , G-CSF ( 262 ) , GDNF ( 209 ) , gefitinib ( 265 ) , genistein ( 224 , 303 , 385 , 392 ) , GF109203X ( 287 , 334 ) , glucosamine ( 211 ) , glucose ( 120 , 145 , 147 , 153 , 200 , 211 , 251 ) , glucose_starvation ( 253 ) , glycine ( 72 ) , GM-CSF ( 180 , 229 ) , Go_6976 ( 139 , 287 ) , GSK2334470 ( 31 ) , guanosine ( 254 ) , H-89 ( 145 , 244 ) , H2O2 ( 145 , 198 , 296 , 303 , 376 ) , haloperidol ( 336 ) , herstatin ( 366 ) , HGF ( 287 ) , high-fat diet ( 189 , 207 , 260 , 320 ) , honokiol ( 109 ) , HU-210 ( 116 ) , hypertension ( 300 ) , hypoxia/reoxygenation ( 120 ) , IBMX ( 145 , 305 ) , IC87114 ( 131 ) , ICAM-1 ( 274 ) , icatibant ( 263 , 300 ) , IFN-gamma ( 254 , 347 , 380 ) , IgE ( 317 , 392 ) , IGF-1 ( 44 , 150 , 204 , 206 , 249 , 267 , 279 , 287 , 288 , 289 , 319 , 330 , 337 , 355 , 359 , 377 , 379 , 385 , 390 , 395 ) , IGF-2 ( 287 , 289 , 359 ) , IGFBP-4 ( 359 ) , IL-10 ( 322 ) , IL-2 ( 248 , 370 ) , IL-21 ( 242 ) , IL-3 ( 152 , 196 , 242 , 302 , 382 ) , IL-4 ( 340 ) , IL-6 ( 356 ) , IL-7 ( 248 ) , imatinib ( 152 , 365 ) , inflammation ( 208 ) , insulin ( 7 , 18 , 22 , 31 , 35 , 42 , 43 , 45 , 46 , 47 , 57 , 64 , 65 , 67 , 86 , 100 , 101 , 108 , 109 , 116 , 125 , 129 , 136 , 147 , 149 , 151 , 159 , 160 , 162 , 164 , 168 , 172 , 176 , 177 , 179 , 182 , 185 , 187 , 188 , 190 , 191 , 192 , 196 , 200 , 204 , 207 , 212 , 213 , 215 , 220 , 226 , 227 , 239 , 245 , 252 , 260 , 261 , 266 , 268 , 272 , 277 , 280 , 283 , 289 , 290 , 298 , 307 , 309 , 311 , 314 , 315 , 320 , 321 , 323 , 326 , 341 , 348 , 354 , 369 , 373 , 377 , 378 , 381 , 384 , 389 , 390 ) , ionizing_radiation ( 204 ) , ionomycin ( 395 ) , ischemia ( 174 , 375 ) , ischemia/reperfusion ( 221 , 357 , 375 ) , JNK_inhibitor_I ( 266 ) , KGF ( 287 ) , KP-392 ( 372 ) , KU-0063794 ( 21 , 86 ) , laminar flow ( 333 ) , latrunculin_A ( 20 ) , let-7 miRNA ( 101 ) , levamfetamine ( 297 ) , LG268 ( 326 ) , LIF ( 318 ) , LIF withdrawal ( 23 ) , lithium ( 272 ) , long-term_potentiation ( 163 ) , LPS ( 13 , 133 , 178 , 322 , 345 , 347 , 362 , 371 , 372 ) , LY294002 ( 22 , 30 , 31 , 67 , 68 , 86 , 102 , 129 , 133 , 167 , 169 , 178 , 196 , 201 , 209 , 216 , 224 , 227 , 260 , 261 , 271 , 276 , 279 , 297 , 303 , 316 , 318 , 319 , 322 , 325 , 327 , 328 , 333 , 334 , 337 , 338 , 343 , 347 , 360 , 365 , 370 , 375 , 382 , 387 , 390 , 392 ) , M-CSF ( 240 , 255 , 361 ) , meal feeding ( 108 ) , mechanical stress ( 86 ) , memantine ( 286 ) , metformin ( 221 ) , methotrexate ( 350 ) , MG132 ( 83 ) , miR-143 ( 125 ) , miRNA ( 25 ) , MK-2206 ( 31 , 67 ) , MK801 ( 337 ) , MMS ( 275 ) , MPTP ( 284 ) , MRS-1523 ( 233 ) , myocardial infarction ( 45 ) , myostatin ( 249 ) , N-cadherin ( 157 ) , NAC ( 376 ) , NBD_peptide ( 76 ) , nerve_damage ( 83 ) , NGF ( 105 ) , Ni(2+) ( 137 ) , nicardipine ( 300 ) , nitric_oxide ( 328 ) , NP68 ( 169 ) , nutlin-3 ( 30 ) , NVP-BKM120 ( 7 ) , okadaic_acid ( 227 , 265 , 287 , 297 , 301 , 379 ) , PA ( 188 ) , palmitate ( 100 , 149 , 220 , 235 , 266 ) , PAN ( 138 ) , PAR1-activating_peptide ( 334 ) , PAR4-activating_peptide ( 334 ) , PD123319 ( 263 , 300 ) , PD98059 ( 22 ) , PDGF ( 164 , 194 , 241 , 243 , 244 , 267 , 268 , 351 , 387 , 388 , 390 ) , PGE2 ( 131 , 145 ) , phentolamine ( 127 ) , phorbol_ester ( 287 , 334 , 395 ) , physostigmine ( 286 ) , PI-103 ( 222 ) , picropodophyllin ( 319 ) , PIF ( 224 ) , PIK90 ( 191 ) , pilocarpine ( 286 ) , pleiotrophin ( 228 ) , poly(I-C) ( 133 ) , PP2 ( 68 , 330 ) , PP242 ( 158 , 191 ) , pregnancy ( 250 ) , pressure ( 202 ) , PTX ( 131 ) , RAD001 ( 210 ) , RANKL ( 304 ) , rapamycin ( 39 , 44 , 101 , 108 , 131 , 141 , 147 , 149 , 150 , 158 , 159 , 161 , 168 , 169 , 177 , 191 , 196 , 212 , 227 , 231 , 257 , 260 , 261 , 267 , 272 , 275 , 288 , 298 , 307 ) , refeeding ( 46 , 165 ) , RGD ( 306 ) , RGE ( 306 ) , rosiglitazone ( 109 , 273 , 326 ) , rottlerin ( 287 ) , SB202190 ( 258 ) , SB203580 ( 141 , 327 ) , SCF ( 205 , 271 , 343 ) , serum ( 101 , 140 , 143 , 154 , 161 , 192 , 261 , 267 , 268 , 270 , 287 , 296 , 360 , 395 ) , serum_starvation ( 18 , 101 , 192 , 261 ) , serum_withdrawal ( 327 ) , Shh ( 216 ) , siRNA ( 187 , 212 , 223 , 239 , 266 , 270 , 280 , 315 ) , skin aging ( 10 ) , SN-50 ( 362 ) , SP600125 ( 290 , 330 ) , sphingomyelinase ( 16 ) , sphingosine_1-phosphate ( 37 ) , SPT ( 233 ) , starvation_medium ( 76 ) , staurosporine ( 364 ) , SU5402 ( 276 ) , SU6656 ( 265 ) , sulforaphane ( 256 ) , sulprostone ( 131 ) , sVCAM-1 ( 274 ) , t-butanol ( 303 ) , tamoxifen ( 236 ) , TGF-alpha ( 366 ) , TGF-beta ( 25 , 345 , 356 , 391 ) , thapsigargin ( 102 ) , Theophylline ( 233 ) , thrombin ( 334 ) , TNF ( 254 , 275 , 280 , 290 , 362 , 379 , 394 ) , Torin1 ( 31 , 131 , 138 ) , TPCK ( 362 ) , triciribine ( 118 ) , troglitazone ( 278 , 288 ) , TUG-891 ( 17 ) , tunicamycin ( 199 ) , U0126 ( 12 , 147 , 169 , 196 , 233 , 238 , 260 , 272 , 276 , 296 , 305 , 368 ) , UV ( 313 , 358 , 376 ) , UVB ( 10 ) , vanadate ( 79 , 145 ) , VEGF ( 206 , 335 ) , VIIa ( 136 ) , vitronectin ( 306 ) , WIN ( 338 ) , Wnt ( 272 , 359 ) , Wnt3a ( 272 ) , wortmannin ( 4 , 18 , 43 , 118 , 131 , 147 , 149 , 159 , 169 , 177 , 201 , 212 , 238 , 249 , 260 , 267 , 272 , 274 , 285 , 288 , 298 , 311 , 314 , 322 , 325 , 351 , 360 , 362 , 365 , 379 , 387 , 388 , 390 , 392 , 393 ) , XL-147 ( 3 ) , YM-254890 ( 17 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 80 , 184 , 198 , 211 , 327 , 334 , 337 , 353 , 365 , 366 , 392 ) , intracellular localization ( 373 , 385 ) , molecular association, regulation ( 89 ) , protein degradation ( 89 ) , ubiquitination ( 89 )
Effects of modification on biological processes:
apoptosis, altered ( 80 , 146 , 198 ) , apoptosis, inhibited ( 183 ) , carcinogenesis, induced ( 26 ) , cell cycle regulation ( 234 ) , cell growth, altered ( 183 , 374 ) , cytoskeletal reorganization ( 183 ) , neural plasticity ( 80 ) , RNA splicing, induced ( 6 ) , signaling pathway regulation ( 80 ) , transcription, induced ( 392 )
Induce interaction with:
CHIP (human) ( 89 )

Disease / Diagnostics Relevance
Relevant diseases:
endometrial cancer ( 282 ) , melanoma skin cancer ( 27 ) , type 2 diabetes ( 260 , 273 , 329 )

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