Ser473
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Site Information
RPHFPQFsysAsGtA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447855
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 , 371 , 382 ) , flow cytometry ( 21 , 105 , 173 , 175 ) , immunoassay ( 63 , 84 , 97 , 98 ) , immunoprecipitation ( 12 , 17 , 21 , 22 , 40 , 59 , 60 , 71 , 86 , 96 , 101 , 140 , 147 , 186 , 190 , 202 , 217 , 401 , 402 ) , mass spectrometry ( 12 , 23 , 26 , 36 , 74 , 81 , 243 ) , mass spectrometry (in vitro) ( 71 , 139 ) , microscopy-colocalization with upstream kinase ( 216 ) , mutation of modification site ( 22 , 71 , 96 , 111 , 152 , 192 , 205 , 207 , 251 , 259 , 288 , 323 , 325 , 333 , 339 , 371 , 382 , 385 , 389 , 402 ) , peptide sequencing ( 164 , 326 ) , phospho-antibody ( 1 , 2 , 6 , 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 68 , 69 , 71 , 72 , 73 , 75 , 76 , 78 , 79 , 80 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 100 , 101 , 102 , 103 , 104 , 106 , 107 , 108 , 109 , 110 , 111 , 113 , 114 , 115 , 118 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 207 , 208 , 209 , 210 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 237 , 238 , 239 , 240 , 241 , 242 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 259 , 260 , 261 , 262 , 263 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 296 , 297 , 298 , 299 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 327 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 , 350 , 351 , 352 , 353 , 354 , 356 , 357 , 358 , 359 , 360 , 361 , 362 , 363 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 372 , 373 , 374 , 375 , 376 , 377 , 378 , 379 , 380 , 381 , 383 , 384 , 385 , 386 , 387 , 388 , 389 , 390 , 391 , 392 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 ) , western blotting ( 1 , 2 , 6 , 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 68 , 69 , 70 , 71 , 72 , 73 , 75 , 76 , 78 , 79 , 80 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 100 , 101 , 102 , 103 , 104 , 106 , 107 , 108 , 109 , 110 , 111 , 113 , 114 , 115 , 118 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 207 , 208 , 209 , 210 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 237 , 238 , 239 , 240 , 241 , 242 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 259 , 260 , 261 , 262 , 263 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 284 , 285 , 288 , 289 , 291 , 292 , 293 , 294 , 296 , 302 , 306 , 312 , 313 , 316 , 318 , 319 , 320 , 321 , 324 , 325 , 326 , 328 , 329 , 330 , 332 , 333 , 335 , 338 , 339 , 342 , 344 , 345 , 349 , 351 , 352 , 356 , 357 , 360 , 362 , 363 , 365 , 366 , 367 , 368 , 370 , 374 , 375 , 376 , 378 , 379 , 380 , 381 , 384 , 385 , 388 , 391 , 395 , 397 , 398 , 399 , 400 , 401 , 402 )
Disease tissue studied:
Alzheimer's disease ( 9 , 111 ) , bone cancer ( 109 ) , brain cancer ( 192 , 204 ) , glioblastoma ( 192 , 204 ) , glioma ( 192 , 204 ) , breast cancer ( 12 , 20 , 187 , 203 , 209 , 250 , 397 ) , cervical cancer ( 80 , 366 ) , cervical adenocarcinoma ( 366 ) , cervical squamous cell carcinoma ( 80 ) , colorectal cancer ( 109 , 152 , 251 , 351 ) , colorectal carcinoma ( 109 , 152 , 251 , 351 ) , endometrial cancer ( 288 ) , endometrial adenocarcinoma ( 288 ) , kidney cancer ( 63 ) , leukemia ( 65 , 84 , 123 ) , chronic myelogenous leukemia ( 84 ) , T cell leukemia ( 65 ) , liver cancer ( 31 , 174 , 205 ) , hepatocellular carcinoma ( 31 ) , lung cancer ( 152 , 237 , 271 , 316 ) , mesothelioma ( 316 ) , non-small cell lung cancer ( 152 , 237 ) , lymphoma ( 314 , 369 ) , B cell lymphoma ( 369 ) , T cell lymphoma ( 314 ) , neuroblastoma ( 23 , 41 , 55 , 124 , 344 , 370 ) , ovarian cancer ( 262 ) , pancreatic cancer ( 128 , 152 , 217 ) , pancreatic carcinoma ( 152 , 217 ) , multiple myeloma ( 86 , 362 ) , prostate cancer ( 149 , 199 ) , melanoma skin cancer ( 1 , 325 ) , fibrosarcoma of soft tissue ( 362 , 385 ) , diabetes mellitus ( 209 , 279 ) , type 2 diabetes ( 168 , 209 , 279 ) , Huntington's disease ( 60 ) , Lafora disease ( 181 ) , Duchenne muscular dystrophy ( 13 ) , schizophrenia ( 342 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 36 , 74 ) , 'brain, cerebral cortex' ( 55 , 68 , 163 , 292 , 335 , 342 , 381 ) , 'brain, embryonic' ( 243 ) , 'brain, embryonic' [BAG1 (mouse)] ( 300 ) , 'brain, hippocampus' ( 55 , 68 , 169 , 252 , 292 ) , 'brain, hippocampus' [APP (human), genetic knockin] ( 111 ) , 'brain, nucleus accumbens' ( 24 ) , 'brain, striatum' ( 60 , 292 , 303 , 343 ) , 'fat, brown'-'fat, brown' ( 133 , 157 ) , 'liver, fetal' ( 282 ) , 'muscle, skeletal' ( 6 , 59 , 71 , 122 , 138 , 157 , 188 , 191 , 196 , 213 , 221 , 223 , 224 , 266 , 315 , 329 , 332 , 348 ) , 'muscle, skeletal' [APPL (human), homozygous knockout] ( 52 ) , 'muscle, skeletal' [DNAPK (mouse), homozygous knockout] ( 210 ) , 'muscle, skeletal' [genetic knockin] ( 52 ) , 'muscle, skeletal' [RICTOR (mouse), homozygous knockout] ( 185 , 232 ) , 'neuron, cortical' ( 87 , 180 , 233 ) , 'neuron, cortical'-brain ( 23 , 79 , 305 ) , 'neuron, cortical'-brain [NYAP2 (mouse), homozygous knockout] ( 91 ) , 'neuron, hippocampal' ( 87 ) , 'neuron, striatal'-brain ( 290 ) , 'neuron, superior cervical ganglion' ( 215 ) , 'renal, podocyte' ( 151 ) , 'stem, embryonic' ( 221 ) , 'stem, mesenchymal' ( 93 ) , 293 (epithelial) ( 17 , 97 , 134 , 146 , 167 , 183 , 192 , 203 , 238 , 294 , 305 , 307 , 354 , 402 ) , 293E (epithelial) ( 251 ) , 32D (myeloid) ( 130 ) , 3T3 (fibroblast) [INSR (human)] ( 266 ) , 3T3 (fibroblast) [INSR (mouse), transfection] ( 202 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 304 , 313 , 316 , 320 , 323 , 360 , 365 , 368 , 373 , 384 , 390 , 392 , 393 , 394 ) , 3T3 (fibroblast) [Src (human)] ( 271 ) , 3T3 (fibroblast) ( 106 , 135 , 155 , 176 , 190 , 193 , 202 , 237 , 250 , 302 , 366 , 367 , 379 , 380 ) , 3T3-L1 (fibroblast) ( 115 , 165 , 166 , 170 , 218 , 245 , 247 , 259 , 266 , 279 , 296 , 375 ) , 4T1 (breast cell) ( 187 , 397 ) , 786-O (renal) ( 63 ) , A431 (epithelial) ( 152 ) , A549 (pulmonary) ( 152 , 237 ) , adipocyte ( 263 ) , adipocyte [F2RL1 (mouse), homozygous knockout] ( 142 ) , adipocyte [N-CoR1 (mouse), homozygous knockout] ( 94 ) , adipocyte-adipose tissue ( 58 ) , adipocyte-adipose tissue [N-CoR1 (mouse), homozygous knockout] ( 94 ) , adipose tissue ( 33 , 59 , 123 , 221 , 266 , 318 , 327 ) , adipose tissue [DNAPK (mouse), homozygous knockout] ( 210 ) , adipose tissue [F2RL1 (mouse), homozygous knockout] ( 142 ) , adipose tissue [p70S6K (mouse), homozygous knockout] ( 326 ) , adipose tissue [RICTOR (mouse), homozygous knockout] ( 185 ) , AE7 ( 254 ) , alphaT3-1 (pituitary cell) ( 64 ) , aorta ( 253 ) , artery ( 226 ) , astrocyte-'brain, striatum' ( 334 ) , AV12 ('neuron, neostriatal') ( 330 ) , B lymphocyte ( 280 ) , B lymphocyte [BCAP (mouse), homozygous knockout] ( 231 ) , B lymphocyte [CD19 (mouse), homozygous knockout] ( 231 ) , B lymphocyte-spleen ( 53 , 98 , 162 ) , B lymphocyte-spleen [PTEN (mouse), transgenic] ( 177 ) , B16F10 ( 1 ) , B9 (fibroblast) ( 362 ) , BAEC (endothelial) ( 298 ) , BaF3 ('B lymphocyte, precursor') [EGFR (human)] ( 271 ) , BaF3 ('B lymphocyte, precursor') ( 75 , 158 , 172 , 202 , 244 , 248 , 268 , 307 , 337 , 388 ) , BALB/MK (keratinocyte) ( 401 ) , BE (melanocyte) ( 325 ) , beta TC3 (pancreatic) ( 217 ) , beta-pancreas ( 272 ) , beta-pancreas [INSR (mouse), transgenic] ( 153 ) , BLMVEC (endothelial) ( 339 ) , BMMC (mast) ( 137 , 398 ) , bone marrow ( 53 , 268 , 328 ) , brain ( 62 , 81 , 225 , 285 ) , brain [CDK5R1 (mouse)] ( 225 ) , brain [laforin (mouse), homozygous knockout] ( 181 ) , brain [NYAP2 (mouse), homozygous knockout] ( 91 ) , breast [PDK1 (mouse), homozygous knockout] ( 20 ) , breast cell ( 12 ) , C141 (epidermal) ( 382 ) , C2C12 (myoblast) [LIN28A (mouse), transfection] ( 107 ) , C2C12 (myoblast) ( 27 , 59 , 101 , 102 , 182 , 230 , 234 , 242 , 255 , 312 , 396 ) , C3H10T1/2 (fibroblast) ( 222 ) , Calu-1 (squamous) ( 237 ) , CaSki (cervical) ( 80 ) , CEF ( 389 ) , CHO (fibroblast) [Tau iso8 (human)] ( 284 ) , CHO (fibroblast) ( 22 , 395 ) , CMT-93 (intestinal) ( 351 ) , colon ( 10 ) , COS (fibroblast) ( 75 , 181 , 202 , 307 , 358 , 371 ) , COS7 (fibroblast) ( 83 ) , CTL-EN (T lymphocyte) ( 235 ) , CTLL-2 (T lymphocyte) ( 376 ) , diaphragm ( 13 ) , DLD1 (intestinal) ( 152 ) , DU 145 (prostate cell) ( 199 ) , E14tg2a ('stem, embryonic') ( 28 , 324 ) , embryo ( 81 , 282 ) , endothelial ( 154 , 212 ) , epithelial ( 216 ) , epithelial-lens ( 249 ) , ES (stem) ( 38 , 113 ) , F9 (testicular) ( 371 ) , Fao (hepatic) ( 205 ) , FDCP-1 (myeloid) ( 308 ) , fibroblast ( 14 ) , fibroblast-embryo [BAG1 (mouse)] ( 300 ) , FL ( 123 ) , G361 (melanocyte) ( 361 ) , GD25 (fibroblast) ( 331 , 357 ) , GT1-7 (neuron) ( 283 ) , H9c2 (myoblast) ( 266 ) , HaCaT (keratinocyte) ( 15 ) , HCCLM3 (hepatic) ( 31 ) , HCT116 (intestinal) ( 109 ) , HCT15 (intestinal) ( 152 ) , heart ( 50 , 138 , 150 , 221 , 227 , 239 , 266 , 289 , 347 ) , heart [AMPKA2 (mouse), homozygous knockout] ( 208 ) , heart [DNAPK (human), transfection] ( 210 ) , HEK293T (epithelial) ( 22 , 51 , 65 , 71 , 79 , 89 , 139 , 140 , 186 , 251 , 399 ) , HeLa (cervical) ( 72 , 96 , 109 , 129 , 146 , 152 , 203 , 251 , 307 , 326 ) , HeLa S3 (cervical) ( 366 ) , hematopoietic stem cells ( 105 ) , hepatocyte ( 134 , 174 ) , hepatocyte-liver ( 73 , 78 , 132 , 195 , 272 ) , hepatocyte-liver [eIF2-alpha (mouse), homozygous knockout] ( 205 ) , hepatocyte-liver [TSC1 (mouse), homozygous knockout] ( 114 ) , HepG2 (hepatic) ( 174 , 402 ) , HT-29 (intestinal) ( 251 ) , HUVEC (endothelial) ( 212 , 263 ) , IC2 (mast) ( 349 ) , intestine ( 29 ) , Ishikawa (endometrial) ( 288 ) , J558L (B lymphocyte) ( 86 ) , J774 (macrophage) ( 378 ) , JB (epithelial) ( 319 , 359 ) , Jurkat (T lymphocyte) ( 207 ) , Jurkat E6-1 (T lymphocyte) ( 65 ) , K562 (erythroid) ( 84 ) , keratinocyte ( 293 ) , keratinocyte-skin ( 287 , 291 ) , keratinocyte-skin [IGF1 (mouse)] ( 294 ) , L6 (myoblast) ( 155 ) , liver ( 33 , 59 , 76 , 81 , 97 , 104 , 123 , 131 , 134 , 140 , 157 , 171 , 201 , 209 , 221 , 266 , 329 , 377 ) , liver [DNAPK (mouse), homozygous knockout] ( 210 ) , liver [p70S6K (mouse), homozygous knockout] ( 326 ) , liver [RICTOR (mouse), homozygous knockout] ( 185 ) , lung ( 212 , 315 ) , lymphocyte ( 21 , 26 , 342 ) , lymphocyte-spleen ( 11 , 25 , 30 ) , lymphocyte-spleen [p53 (mouse), transfection] ( 214 ) , M059J (glial) ( 192 , 240 ) , M1 (myeloid) ( 84 ) , M2-10B4 ( 39 ) , macrophage-bone marrow ( 9 , 18 , 35 , 246 , 261 , 352 ) , macrophage-peritoneum ( 184 ) , mammary gland ( 16 ) , mast-bone marrow ( 34 , 277 , 323 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 179 ) , MCF-7 (breast cell) ( 203 , 250 ) , MDA-MB-453 (breast cell) ( 209 ) , MEF (fibroblast) ( 17 , 59 , 63 , 66 , 72 , 82 , 83 , 85 , 89 , 92 , 95 , 127 , 129 , 143 , 144 , 147 , 159 , 160 , 165 , 167 , 178 , 191 , 192 , 198 , 204 , 220 , 222 , 237 , 240 , 241 , 251 , 259 , 265 , 267 , 273 , 274 , 275 , 276 , 278 , 281 , 356 ) , MEF (fibroblast) [Akt1 (mouse), heterozygous knockout] ( 173 ) , MEF (fibroblast) [Akt1 (mouse), homozygous knockout] ( 108 ) , MEF (fibroblast) [Akt2 (mouse), homozygous knockout] ( 173 ) , MEF (fibroblast) [BAG4 (mouse), homozygous knockout] ( 110 ) , MEF (fibroblast) [DNAPK (mouse), homozygous knockout] ( 210 ) , MEF (fibroblast) [EIF4E (mouse), genetic knockin] ( 149 ) , MEF (fibroblast) [GADD34 (human)] ( 238 ) , MEF (fibroblast) [IGF1R (mouse)] ( 299 , 311 , 321 ) , MEF (fibroblast) [LKB1 (mouse)] ( 338 ) , MEF (fibroblast) [mTOR (mouse), homozygous knockout] ( 203 ) , MEF (fibroblast) [NRas (mouse), homozygous knockout] ( 400 ) , MEF (fibroblast) [PDGFRA (mouse), genetic knockin] ( 200 ) , MEF (fibroblast) [PKR (mouse), homozygous knockout] ( 168 ) , MEF (fibroblast) [RICTOR (human), homozygous knockout] ( 146 ) , MEF (fibroblast) [Sin1 (mouse), homozygous knockout] ( 156 , 197 ) , MEF (fibroblast) [TMEM55B (mouse), homozygous knockout] ( 189 ) , MES (pulmonary) ( 316 ) , MHCC97-L (hepatic) ( 31 ) , MIA PaCa-2 (pancreatic) ( 152 ) , microglia ( 260 ) , mIMCD-3 (epithelial) ( 374 ) , mLEC (epithelial) ( 121 ) , MLO-Y4 (osteoblast) ( 62 ) , MMC (mesangial) ( 257 ) , MMTV-PyMT (breast cell) [JNK2 (mouse), homozygous knockout] ( 125 ) , MPC-11 (B lymphocyte) ( 362 ) , MS1 (endothelial) ( 312 ) , muscle ( 33 , 123 , 279 ) , muscle [laforin (mouse), homozygous knockout] ( 181 ) , muscle [p70S6K (mouse), homozygous knockout] ( 326 ) , MVT-1 (epithelial) ( 12 ) , myeloid ( 261 ) , myoblast ( 224 , 333 ) , myocyte-heart ( 49 , 54 , 69 , 126 , 234 , 256 , 391 ) , N1E-115 (neuron) ( 23 , 344 ) , NCI-H1299 (pulmonary) ( 152 ) , NCI-H157 (pulmonary) ( 237 ) , Neuro-2a (neuron) ( 41 , 124 , 370 ) , neuron-'brain, cerebral cortex' ( 363 ) , neuron-'brain, cerebral cortex' [STAT1 (mouse), homozygous knockout] ( 363 ) , neuron-'brain, hippocampus' ( 41 ) , neuron-dorsal root ganglia ( 90 ) , neutrophil ( 56 , 88 ) , NHDF (fibroblast) ( 66 ) , NMuMG (epithelial) ( 40 , 397 ) , osteoclast ( 261 ) , ovarian ( 262 ) , pancreatic ( 128 ) , PaTu (pancreatic) ( 152 ) , PC-12 (chromaffin) ( 309 ) , PC3 (prostate cell) ( 199 ) , penis ( 341 ) , platelet-blood ( 7 , 103 , 340 ) , preadipocyte ( 263 ) , preosteoclast ( 310 ) , prostate ( 173 , 216 ) , prostate [homozygous knockout] ( 118 ) , Rat1 (fibroblast) ( 240 , 278 ) , RAW 264 (macrophage) ( 353 ) , RAW 264.7 (macrophage) ( 139 ) , RIE (epithelial) ( 278 ) , SCC16-5 (fibroblast) ( 386 ) , sertoli-testis ( 19 ) , SF9 ( 390 ) , SiHa (squamous) ( 80 ) , skin ( 15 ) , SKNSH (neural crest) ( 55 ) , SKOV-3 (ovarian) ( 262 ) , SN4741 (neuron) ( 345 ) , spleen ( 53 , 328 ) , SV40 ( 383 ) , SYF (fibroblast) ( 148 ) , T lymphocyte-blood ( 346 ) , T lymphocyte-lymph node ( 175 ) , T lymphocyte-lymph node [PKCT (mouse), homozygous knockout] ( 145 ) , T lymphocyte-spleen ( 53 , 61 , 136 , 228 , 254 , 270 ) , T lymphocyte-spleen [PKCT (mouse), homozygous knockout] ( 145 ) , T lymphocyte-thymus ( 314 ) , thoracic aorta ( 269 , 306 ) , thymocyte ( 164 ) , thymocyte [CBL (mouse), homozygous knockout] ( 161 ) , thyroid [Akt1 (mouse), homozygous knockout] ( 100 ) , U-251 MG (glial) ( 204 ) , U2OS (bone cell) [GR (human)] ( 307 ) , U2OS (bone cell) ( 109 ) , UOK-101 (renal) ( 63 ) , uterus ( 288 , 301 ) , VSMC-aorta ( 322 ) , WEHI-164 (fibroblast) ( 385 ) , WEHI-231 (B lymphocyte) ( 369 )

Upstream Regulation
Regulatory protein:
14-3-3 zeta (mouse) ( 186 ) , ACVR2B (mouse) ( 255 ) , ADRB1 (mouse) ( 133 ) , Akt1 (human) ( 216 ) , Akt1 (mouse) ( 32 , 100 , 238 , 398 ) , Akt2 (mouse) ( 104 , 164 ) , Akt3 (mouse) ( 103 ) , ALK (human) ( 158 ) , AMPKA2 (mouse) ( 208 ) , APP (mouse) ( 55 ) , APPL (human) ( 59 ) , APPL2 (human) ( 52 ) , AS160 (human) ( 138 ) , ATF6A (mouse) ( 205 ) , BAFF (mouse) ( 280 ) , BAG1 (mouse) ( 300 ) , BAG4 (mouse) ( 110 ) , BCAP (mouse) ( 231 ) , BCR-ABL1 (human) ( 271 ) , BRCA1 (human) ( 116 ) , Brk (human) ( 148 ) , Btk (mouse) ( 398 ) , C3aR (mouse) ( 228 ) , C5aR (mouse) ( 228 ) , CASP1 (mouse) ( 123 ) , caveolin-1 (mouse) ( 113 ) , CBL (mouse) ( 161 ) , CD151 (mouse) ( 34 ) , CD19 (mouse) ( 231 ) , CDC42 iso1 (mouse) ( 291 ) , CDH2 (mouse) ( 163 ) , CDK5 (mouse) ( 225 ) , CDK5R1 (mouse) ( 225 ) , CLK2 (human) ( 134 ) , DICER1 (mouse) ( 30 ) , DNAPK (mouse) ( 192 , 210 ) , EIF4E (mouse) ( 149 ) , ERK5 (human) ( 339 ) , F2RL1 (mouse) ( 142 ) , FAK (mouse) ( 154 ) , FGFR1 (human) ( 244 ) , FOXO1A (human) ( 159 ) , FOXO1A (mouse) ( 63 , 159 , 263 ) , Fyn (mouse) ( 175 ) , GAB2 (mouse) ( 277 ) , GADD34 (human) ( 238 ) , GCN2 (mouse) ( 108 ) , GILZ (human) ( 84 ) , GLRX1 (mouse) ( 249 ) , GPM6A (human) ( 41 ) , GPX1 (mouse) ( 329 ) , GRB10 (human) ( 58 , 75 ) , GRB10 (mouse) ( 37 ) , Huntingtin (mouse) ( 343 ) , ICMT (mouse) ( 356 ) , IFI16 (mouse) ( 229 ) , IGF1R (mouse) ( 255 , 336 ) , IKKA (human) ( 83 ) , IKKA (mouse) ( 280 ) , IKKB (human) ( 83 ) , IKKG (human) ( 83 ) , IKKG (mouse) ( 286 ) , ILK (human) ( 93 ) , ILK (mouse) ( 10 , 224 ) , IRS1 (human) ( 54 , 272 ) , IRS1 (mouse) ( 272 ) , IRS2 (human) ( 54 ) , IRS2 (mouse) ( 272 ) , ITGA9 (human) ( 268 ) , ITGB1 (human) ( 357 ) , ITGB1 (mouse) ( 196 ) , ITGB3 (mouse) ( 1 ) , JAK2 (mouse) ( 388 ) , JIP1 (mouse) ( 327 ) , JNK1 (mouse) ( 126 ) , JNK2 (mouse) ( 125 ) , K17 (mouse) ( 287 ) , KRas (mouse) ( 275 , 401 ) , LAB (mouse) ( 270 ) , laforin (mouse) ( 181 ) , LAMTOR1 (human) ( 160 ) , LAMTOR2 (mouse) ( 160 ) , LIMS1 (human) ( 152 ) , LIMS1 (mouse) ( 152 ) , LIN28A (mouse) ( 107 ) , LIN28B (mouse) ( 107 ) , LKB1 (mouse) ( 223 ) , LPIN1 (mouse) ( 194 ) , LST8 (mouse) ( 267 ) , LYN (mouse) ( 398 ) , MEK5 (human) ( 339 ) , Met (mouse) ( 1 ) , Mnk1 (mouse) ( 237 ) , Mnk2 (mouse) ( 237 ) , MT1 (mouse) ( 289 ) , mTOR (mouse) ( 19 , 102 ) , Musashi-1 (mouse) ( 29 ) , MYD88 (human) ( 184 ) , N-CoR1 (mouse) ( 94 ) , NF1 (mouse) ( 265 ) , NFkB-p100 (mouse) ( 17 ) , NLRP3 (mouse) ( 123 ) , NPM1 (human) ( 158 ) , NRas (mouse) ( 400 ) , NYAP2 (mouse) ( 91 ) , P38A (mouse) ( 147 ) , p53 (mouse) ( 44 ) , p70S6K (mouse) ( 102 ) , PAG (rat) ( 220 ) , PDGFRA (mouse) ( 200 ) , PDK1 (mouse) ( 20 , 221 ) , PERK (mouse) ( 108 ) , PGGT1B (mouse) ( 18 ) , PHB (human) ( 182 ) , PIK3C2A (mouse) ( 375 ) , PIK3CA (mouse) ( 92 ) , PIK3CG (human) ( 88 ) , PIK3R1 (human) ( 83 ) , PIKFYVE (human) ( 71 ) , PIKFYVE (mouse) ( 71 ) , Pim1 (human) ( 199 ) , PKCA (human) ( 145 , 293 ) , PKCA (mouse) ( 212 ) , PKCD (human) ( 293 ) , PKCE (human) ( 293 ) , PKCI (mouse) ( 364 ) , PKCT (mouse) ( 226 ) , PKR (mouse) ( 168 ) , PLCB2 (human) ( 88 ) , PPP2R5B (human) ( 134 ) , PPP2R5B (mouse) ( 193 ) , PSEN1 (mouse) ( 55 ) , PTEN (mouse) ( 23 , 32 , 38 , 42 , 43 , 118 , 177 , 198 , 204 , 285 , 288 ) , PTGER3 (mouse) ( 137 ) , PTGER4 (mouse) ( 151 ) , PYCARD (mouse) ( 123 ) , Raptor (mouse) ( 102 , 137 , 276 ) , Rb (mouse) ( 44 ) , RBPJ (mouse) ( 47 ) , Ret (human) ( 215 ) , RHEB (mouse) ( 102 ) , RICTOR (human) ( 16 , 97 , 167 , 178 , 185 ) , RICTOR (mouse) ( 63 , 72 , 82 , 137 , 146 , 157 , 159 , 167 , 198 , 218 , 232 , 267 ) , ROCK1 (mouse) ( 188 ) , SCD (mouse) ( 318 ) , SGK1 (mouse) ( 61 ) , SH3BP2 (mouse) ( 261 ) , SHC1 (mouse) ( 257 ) , SHP-2 (mouse) ( 179 , 373 ) , SIGLEC7 (mouse) ( 56 ) , SIK (human) ( 33 ) , Sin1 (human) ( 156 ) , Sin1 (mouse) ( 92 , 156 , 197 , 274 ) , SIRT1 (human) ( 97 ) , SIRT1 (mouse) ( 141 ) , SMO (mouse) ( 14 ) , SPHK1 (human) ( 132 ) , Src (human) ( 271 ) , STAT3 (human) ( 174 ) , Syk (mouse) ( 398 ) , syndecan-4 (mouse) ( 212 ) , TBK1 (mouse) ( 139 , 275 ) , TCL1A (mouse) ( 399 ) , TDGF1 (mouse) ( 105 ) , TMEM55B (mouse) ( 189 ) , TORC2 (mouse) ( 194 ) , TREM2 (mouse) ( 9 ) , TSC1 (mouse) ( 114 , 165 , 273 ) , TSC2 (mouse) ( 85 , 89 , 153 , 159 , 251 , 273 , 276 , 281 ) , TTC3 (human) ( 176 ) , VEGF (human) ( 70 )
Putative in vivo kinases:
Akt1 (mouse) ( 402 ) , ILK (human) ( 352 ) , P38A (mouse) ( 333 ) , PIK3C2A (human) ( 70 ) , PKCB (mouse) ( 323 )
Kinases, in vitro:
Akt1 (mouse) ( 402 ) , mTOR (human) ( 84 ) , mTOR (mouse) ( 72 , 297 ) , PKCA (mouse) ( 145 )
Putative upstream phosphatases:
PPP2CA (human) ( 134 ) , PTEN (mouse) ( 390 )
Treatments:
1-butanol ( 309 ) , 4-HT ( 159 , 202 ) , 8-(3-chlorostyryl) caffeine ( 239 ) , 8-Rp-cAMP ( 250 ) , A-443654 ( 202 ) , acadesine ( 71 , 233 , 338 ) , ACh ( 322 ) , actinomycin_D ( 368 ) , activin ( 362 ) , adiponectin ( 59 , 187 ) , adriamycin ( 147 ) , AG1433 ( 357 ) , AG1478 ( 309 ) , Akt-I-1 ( 202 ) , Akt_activator_compound_11 ( 135 ) , Akt_inhibitor_VIII ( 62 , 88 , 92 , 93 , 108 , 202 ) , Akt_inhibitor_X ( 69 ) , alloxazine ( 239 ) , alpha-lipoic_acid ( 124 ) , AM251 ( 122 ) , amino_acid_starvation ( 267 ) , amino_acids ( 89 , 155 , 174 , 273 ) , angiopoietin-1 ( 312 ) , angiopoietin-2 ( 312 ) , angiotensin_2 ( 141 , 269 ) , anti-CD3 ( 11 , 145 , 161 ) , anti-CD3/CD28 ( 30 , 43 , 61 , 136 , 161 , 207 , 228 , 270 ) , anti-CD4 ( 161 ) , anti-CTLA-4 ( 175 ) , anti-IgB ( 231 ) , anti-IgE ( 179 ) , anti-IgM ( 98 , 162 , 177 ) , anti-integrin_alpha9beta1 ( 80 ) , anti-ITGA4 ( 312 ) , anti-ITGA6 ( 312 ) , anti-ITGB1 ( 357 ) , anti-ITGB3 ( 312 ) , anti-kappa chain antibody ( 25 ) , anti-TCR ( 61 ) , anti-TNFalpha ( 123 ) , arsenite ( 359 ) , AS252424 ( 137 ) , atorvastatin ( 239 ) , axatomy ( 45 ) , AZD8055 ( 66 ) , bacterial infection ( 351 ) , BAPTA-AM ( 340 , 379 ) , BDNF ( 23 , 79 ) , BI-D1870 ( 175 ) , bicuculline ( 79 ) , bisindolylmaleimide ( 145 ) , blood pressure ( 269 ) , bromocriptine ( 345 ) , butaprost ( 137 ) , BX795 ( 197 ) , C3aR_antagonist ( 228 ) , C5aR_antagonist ( 228 ) , calphostin_C ( 93 ) , calyculin_A ( 293 ) , canertinib ( 225 ) , cangrelor ( 340 ) , CAS_227449-73-2 ( 75 ) , castration ( 118 ) , catalase ( 382 ) , cell_adhesion ( 331 ) , ciclopirox_olamine ( 121 ) , cilengitide ( 1 ) , cisplatin ( 66 ) , clonidine ( 322 ) , cold_water_stress ( 252 ) , colforsin ( 151 , 311 , 392 ) , ConA ( 201 ) , cpd22 ( 10 ) , CRP ( 258 ) , culturing_of_cells ( 87 ) , CXCL12 ( 369 ) , CXCL5 ( 191 ) , cyclic_stretch ( 151 ) , cycloheximide ( 85 , 144 , 368 ) , dactolisib ( 63 , 118 ) , development ( 289 ) , dexamethasone ( 84 , 166 ) , DI-PHPB ( 55 ) , DNP ( 398 ) , doconexent ( 370 ) , DPCPX ( 239 ) , Dynasore ( 98 ) , EDTA ( 312 ) , EGF ( 23 , 110 , 125 , 148 , 173 , 189 , 190 , 229 , 264 , 274 , 293 , 309 , 356 , 361 , 372 , 373 , 374 , 392 , 397 , 401 ) , EGTA ( 309 , 343 ) , eplerenone ( 13 ) , Epo ( 172 ) , estradiol ( 250 , 290 , 296 , 391 ) , ethanol ( 377 ) , ether ( 252 ) , etoposide ( 66 ) , exercise ( 57 , 223 , 224 ) , exercise training ( 54 ) , faslodex ( 296 ) , fasting ( 6 , 51 , 83 , 134 , 141 , 171 ) , FGF2 ( 212 , 274 , 293 , 298 , 372 ) , fibrinogen ( 56 ) , fingolimod ( 60 ) , fMLP ( 88 ) , food deprivation ( 252 ) , fostriecin ( 303 ) , G-CSF ( 268 ) , GDNF ( 215 ) , gefitinib ( 271 ) , genistein ( 230 , 309 , 391 , 398 ) , GF109203X ( 293 , 340 ) , glucosamine ( 217 ) , glucose ( 126 , 138 , 151 , 153 , 159 , 206 , 217 , 257 ) , glucose_starvation ( 259 ) , glycine ( 79 ) , GM-CSF ( 186 , 235 ) , Go_6976 ( 93 , 145 , 212 , 293 ) , GSK2334470 ( 36 ) , guanosine ( 260 ) , H-89 ( 151 , 250 ) , H-CHO ( 104 ) , H2O2 ( 97 , 151 , 204 , 302 , 309 , 382 ) , haloperidol ( 342 ) , herstatin ( 372 ) , HGF ( 293 ) , high-fat diet ( 58 , 195 , 213 , 266 , 326 ) , high_glucose ( 132 ) , honokiol ( 115 ) , HU-210 ( 122 ) , hypertension ( 306 ) , hypoxia/reoxygenation ( 126 ) , IBMX ( 2 , 89 , 151 , 311 ) , IC87114 ( 137 ) , ICAM-1 ( 280 ) , icatibant ( 269 , 306 ) , IFN-gamma ( 260 , 353 , 386 ) , IgE ( 323 , 398 ) , IGF-1 ( 49 , 156 , 210 , 212 , 255 , 273 , 285 , 293 , 294 , 295 , 325 , 336 , 343 , 361 , 365 , 383 , 385 , 391 , 396 , 401 ) , IGF-2 ( 293 , 295 , 365 ) , IGFBP-4 ( 365 ) , IL-10 ( 328 ) , IL-1b ( 123 ) , IL-2 ( 254 , 376 ) , IL-21 ( 248 ) , IL-3 ( 158 , 202 , 248 , 308 , 388 ) , IL-4 ( 346 ) , IL-6 ( 362 ) , IL-7 ( 53 , 254 ) , imatinib ( 158 , 371 ) , inflammation ( 214 ) , insulin ( 2 , 12 , 23 , 27 , 36 , 40 , 47 , 48 , 50 , 51 , 52 , 54 , 59 , 64 , 71 , 72 , 73 , 74 , 76 , 89 , 93 , 97 , 104 , 106 , 107 , 114 , 115 , 122 , 123 , 131 , 134 , 135 , 138 , 141 , 142 , 153 , 155 , 157 , 165 , 166 , 168 , 170 , 174 , 178 , 182 , 183 , 185 , 188 , 191 , 193 , 194 , 196 , 197 , 198 , 202 , 206 , 210 , 213 , 218 , 219 , 221 , 226 , 232 , 233 , 245 , 251 , 258 , 266 , 267 , 272 , 274 , 278 , 283 , 286 , 289 , 295 , 296 , 304 , 313 , 315 , 317 , 320 , 321 , 326 , 327 , 329 , 332 , 347 , 354 , 360 , 375 , 379 , 383 , 384 , 387 , 390 , 395 , 396 ) , ionizing_radiation ( 66 , 210 ) , ionomycin ( 401 ) , ischemia ( 180 , 381 ) , ischemia/reperfusion ( 227 , 363 , 381 ) , isoproterenol ( 2 , 69 ) , JAK_inhibitor_I ( 70 ) , JNK_inhibitor_I ( 272 ) , KGF ( 293 ) , KP-392 ( 378 ) , KU-0063794 ( 26 , 93 ) , laminar flow ( 339 ) , latrunculin_A ( 25 ) , let-7 miRNA ( 107 ) , leucine ( 83 ) , levamfetamine ( 303 ) , LG268 ( 332 ) , LIF ( 324 ) , LIF withdrawal ( 28 ) , lithium ( 278 ) , long-term_potentiation ( 169 ) , LPS ( 18 , 139 , 184 , 328 , 351 , 353 , 368 , 377 , 378 ) , LY294002 ( 1 , 27 , 35 , 36 , 70 , 74 , 75 , 92 , 93 , 108 , 135 , 139 , 173 , 175 , 184 , 202 , 207 , 215 , 222 , 230 , 233 , 266 , 267 , 277 , 282 , 285 , 303 , 309 , 322 , 324 , 325 , 328 , 331 , 333 , 334 , 339 , 340 , 343 , 344 , 349 , 353 , 366 , 371 , 376 , 381 , 388 , 393 , 396 , 398 ) , M-CSF ( 246 , 261 , 367 ) , meal feeding ( 114 , 132 ) , mechanical stress ( 62 , 93 ) , memantine ( 292 ) , metformin ( 78 , 227 ) , methotrexate ( 356 ) , methyl-beta-cyclodextrin ( 113 ) , MG132 ( 90 ) , miR-143 ( 131 ) , miRNA ( 30 ) , MK-2206 ( 36 , 63 , 74 ) , MK801 ( 343 ) , MMS ( 281 ) , MPTP ( 290 ) , MRS-1523 ( 239 ) , mutation ( 92 ) , myocardial infarction ( 50 ) , myostatin ( 255 ) , N-cadherin ( 163 ) , NAC ( 97 , 382 ) , NBD_peptide ( 83 ) , nerve_damage ( 90 ) , NGF ( 111 ) , Ni(2+) ( 143 ) , nicardipine ( 306 ) , nitric_oxide ( 334 ) , NKH_477 ( 89 ) , NP68 ( 175 ) , nutlin-3 ( 35 ) , NVP-BKM120 ( 12 , 63 ) , okadaic_acid ( 134 , 233 , 271 , 293 , 303 , 307 , 385 ) , OVA ( 61 ) , PA ( 194 ) , palmitate ( 106 , 155 , 226 , 241 , 272 ) , PAN ( 144 ) , PAR1-activating_peptide ( 340 ) , PAR4-activating_peptide ( 340 ) , PD123319 ( 269 , 306 ) , PD98059 ( 27 ) , PDGF ( 170 , 200 , 247 , 249 , 250 , 273 , 274 , 357 , 393 , 394 , 396 ) , PF 573228 ( 1 ) , PF-4708671 ( 92 ) , PGE2 ( 137 , 151 ) , PHA-665752 ( 1 ) , phentolamine ( 133 ) , phorbol_ester ( 88 , 293 , 340 , 401 ) , physostigmine ( 292 ) , PI-103 ( 228 ) , picropodophyllin ( 325 ) , PIF ( 230 ) , PIK90 ( 197 ) , pilocarpine ( 292 ) , pleiotrophin ( 234 ) , poly(I-C) ( 139 ) , PP2 ( 75 , 336 ) , PP242 ( 61 , 164 , 197 ) , pregnancy ( 256 ) , pressure ( 208 ) , PTX ( 137 ) , RAD001 ( 216 ) , RANKL ( 310 ) , rapamycin ( 44 , 49 , 66 , 92 , 93 , 107 , 114 , 137 , 147 , 153 , 155 , 156 , 164 , 165 , 167 , 174 , 175 , 183 , 197 , 202 , 212 , 218 , 233 , 237 , 263 , 266 , 267 , 273 , 278 , 281 , 294 , 304 , 313 ) , refeeding ( 51 , 134 , 171 ) , resveratrol ( 97 ) , RGD ( 312 ) , RGE ( 312 ) , rosiglitazone ( 115 , 279 , 332 ) , rottlerin ( 293 ) , SB202190 ( 264 ) , SB203580 ( 147 , 333 ) , SCF ( 211 , 277 , 349 ) , serum ( 62 , 107 , 146 , 149 , 160 , 167 , 198 , 267 , 273 , 274 , 276 , 293 , 302 , 366 , 401 ) , serum_starvation ( 23 , 83 , 107 , 198 , 267 ) , serum_withdrawal ( 333 ) , Shh ( 222 ) , siRNA ( 193 , 218 , 229 , 245 , 272 , 276 , 286 , 321 ) , skin aging ( 15 ) , SN-50 ( 368 ) , SP600125 ( 296 , 336 ) , sphingomyelinase ( 21 , 132 ) , sphingosine_1-phosphate ( 42 ) , SPT ( 239 ) , starvation_medium ( 83 ) , staurosporine ( 370 ) , SU5402 ( 282 ) , SU6656 ( 271 ) , sulforaphane ( 262 ) , sulprostone ( 137 ) , sVCAM-1 ( 280 ) , t-butanol ( 309 ) , tamoxifen ( 242 ) , TGF-alpha ( 372 ) , TGF-beta ( 30 , 351 , 362 , 397 ) , thapsigargin ( 108 ) , Theophylline ( 239 ) , thrombin ( 103 , 340 ) , TNF ( 123 , 260 , 281 , 286 , 296 , 368 , 385 , 400 ) , topotecan ( 66 ) , Torin1 ( 36 , 137 , 144 ) , TPCK ( 368 ) , triciribine ( 124 ) , troglitazone ( 284 , 294 ) , TUG-891 ( 22 ) , tunicamycin ( 205 ) , U0126 ( 17 , 153 , 175 , 202 , 239 , 244 , 266 , 278 , 282 , 302 , 311 , 374 ) , UV ( 319 , 364 , 382 ) , UVB ( 15 ) , vanadate ( 86 , 151 ) , VEGF ( 212 , 341 ) , VIIa ( 142 ) , vitronectin ( 312 ) , WIN ( 344 ) , Wnt ( 278 , 365 ) , Wnt3a ( 278 ) , wortmannin ( 2 , 9 , 23 , 48 , 92 , 124 , 137 , 153 , 155 , 165 , 175 , 183 , 207 , 218 , 244 , 255 , 266 , 273 , 278 , 280 , 291 , 294 , 304 , 317 , 320 , 328 , 331 , 357 , 366 , 368 , 371 , 385 , 393 , 394 , 396 , 398 , 399 ) , XL-147 ( 8 ) , YM-254890 ( 22 )

Downstream Regulation
Effects of modification on Akt1:
activity, induced ( 62 , 69 ) , enzymatic activity, induced ( 53 , 84 , 87 , 97 , 101 , 102 , 138 , 190 , 204 , 217 , 333 , 340 , 343 , 359 , 371 , 372 , 398 ) , intracellular localization ( 97 , 379 , 391 ) , molecular association, regulation ( 96 , 134 ) , phosphorylation ( 84 , 93 , 134 , 141 ) , protein degradation ( 96 ) , ubiquitination ( 96 )
Effects of modification on biological processes:
apoptosis, altered ( 87 , 152 , 204 ) , apoptosis, inhibited ( 63 , 84 , 189 ) , carcinogenesis, induced ( 1 , 31 , 63 , 80 ) , cell cycle regulation ( 63 , 240 ) , cell differentiation, induced ( 102 ) , cell growth, altered ( 189 , 380 ) , cell growth, induced ( 63 , 113 ) , cell motility, induced ( 80 ) , cytoskeletal reorganization ( 189 ) , neural plasticity ( 87 ) , RNA splicing, induced ( 11 ) , signaling pathway regulation ( 1 , 68 , 69 , 70 , 73 , 87 , 102 , 157 , 212 ) , transcription, induced ( 398 ) , transcription, inhibited ( 84 , 97 ) , translation, inhibited ( 84 )
Induce interaction with:
CHIP (human) ( 96 ) , PPP2CA (human) ( 134 ) , PPP2R5B (mouse) ( 134 )

Disease / Diagnostics Relevance
Relevant diseases:
endometrial cancer ( 288 ) , melanoma skin cancer ( 32 ) , type 2 diabetes ( 266 , 279 , 335 )

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