Ser180
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Home > Phosphorylation Site Page: > Ser180  -  AQP4 (human)

Site Information
TIFASCDsKRTDVTG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467301

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , astrocytoma ( 1 )
Relevant cell line - cell type - tissue:
D54 (astrocyte) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Treatments:
chelerythrine ( 1 ) , phorbol_ester ( 1 ) , thrombin ( 1 )

Downstream Regulation
Effects of modification on AQP4:
activity, inhibited ( 1 )
Effects of modification on biological processes:
cell motility, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
astrocytoma ( 1 )

References 

1

McCoy ES, Haas BR, Sontheimer H (2010) Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion. Neuroscience 168, 971-81
19761816   Curated Info