Ser479
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser479  -  p63 (human)

Site Information
MNKLPsVsQLINPQQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4668107

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bone cancer ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 1 , 2 )
Kinases, in vitro:
ATM (human) ( 2 )
Treatments:
cisplatin ( 1 , 2 ) , KU-55933 ( 1 , 2 )

Downstream Regulation
Effects of modification on p63:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell growth, inhibited ( 1 ) , transcription, altered ( 1 )
Induce interaction with:
DNA ( 1 ) , NFYA (human) ( 1 )

References 

1

Huang Y, et al. (2010) Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure. Cell Cycle 9, 328-38
20023394   Curated Info

2

Huang Y, et al. (2008) ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle 7, 2846-55
18769144   Curated Info