Lys412

Site Information
DRKPREkkLITVQVV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4666600

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	dendritic cell ( 1 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on IRF5:	intracellular localization ( 2 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:	LYN (human) ( 1 )

References
1	Ban T, et al. (2016) Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45, 319-32 27521268 Curated Info
2	Balkhi MY, Fitzgerald KA, Pitha PM (2008) Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol 28, 7296-308 18824541 Curated Info