Ser2522
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Home > Phosphorylation Site Page: > Ser2522  -  Notch 1 (human)

Site Information
EsPDQWssssPHSNV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467288

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , [32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
bone marrow ( 1 ) , HEK293T (epithelial) ( 1 ) , U2OS (bone cell) [GR (human)] ( 1 )

Downstream Regulation
Effects of modification on Notch 1:
protein degradation ( 1 ) , receptor inactivation, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
acute lymphocytic leukemia ( 1 )

References 

1

Chiang MY, et al. (2006) Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol 26, 6261-71
16880534   Curated Info

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