Ser101
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Home > Phosphorylation Site Page: > Ser101  -  SRC-3 (human)

Site Information
DVQkADVssTGQGVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4661901

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , ZR-75-1 (breast cell) ( 2 )

Upstream Regulation
Putative upstream phosphatases:
PPP1CA (human) ( 2 )
Phosphatases, in vitro:
PPP1CA (human) ( 2 )

Downstream Regulation
Effects of modification on SRC-3:
molecular association, regulation ( 1 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 )
Induce interaction with:
SPOP (human) ( 1 )

References 

1

Li C, et al. (2011) Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene 30, 4350-64
21577200   Curated Info

2

Li C, et al. (2008) Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell 31, 835-49
18922467   Curated Info

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