Ser862
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Home > Phosphorylation Site Page: > Ser862  -  mGluR7 (rat)

Site Information
NVQKRKRsFKAVVTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2846504

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , 293 (epithelial) ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 ) , PKCA (human) ( 2 ) , PKG1 (human) ( 2 )
Putative upstream phosphatases:
PPP1CA (rat) ( 1 )
Treatments:
AMPA ( 1 ) , calyculin_A ( 1 ) , FK506 ( 1 ) , fostriecin ( 1 ) , glutamic acid ( 1 ) , L-AP4 ( 1 ) , NMDA ( 1 ) , okadaic_acid ( 1 )

Downstream Regulation
Effects of modification on mGluR7:
molecular association, regulation ( 2 ) , receptor internalization, inhibited ( 1 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 2 )

References 

1

Suh YH, et al. (2013) Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1. J Biol Chem 288, 17544-51
23612982   Curated Info

2

Sorensen SD, et al. (2002) Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol Pharmacol 61, 1303-12
12021391   Curated Info

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