Thr366
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Home > Phosphorylation Site Page: > Thr366  -  LKB1 (mouse)

Site Information
IEDGIIytQDFTVPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448151

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 1 , 3 , 4 , 5 ) , peptide sequencing ( 5 ) , phospho-antibody ( 1 , 3 , 4 , 5 ) , phosphoamino acid analysis ( 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 1 , 3 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal'-'brain, embryonic' ( 3 ) , 293 (epithelial) ( 5 ) , A549 (pulmonary) ( 1 ) , G361 (melanocyte) ( 4 ) , HEK293T (epithelial) ( 3 ) , NCI-H2030 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ATM (mouse) ( 4 ) , LKB1 (mouse) ( 5 )
Kinases, in vitro:
ATM (mouse) ( 4 ) , DNAPK (mouse) ( 4 ) , LKB1 (mouse) ( 5 )
Treatments:
EGF ( 4 ) , IGF-1 ( 4 ) , ionizing_radiation ( 4 )

Downstream Regulation
Effects of modification on LKB1:
protein degradation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , DNA repair, altered ( 2 )

References 

1

Richer AL, et al. (2017) WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res 77, 4663-4672
28652249   Curated Info

2

Esteve-Puig R, et al. (2014) A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21WAF1/CIP1) Degradation. PLoS Genet 10, e1004721
25329316   Curated Info

3

Shelly M, et al. (2007) LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129, 565-77
17482549   Curated Info

4

Sapkota GP, et al. (2002) Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J 368, 507-16
12234250   Curated Info

5

Sapkota GP, et al. (2002) Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J 362, 481-90
11853558   Curated Info