Ser666

Site Information
EksPsFAsEWDEIEK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4650004

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 6 )
Disease tissue studied:	breast cancer ( 3 , 4 ) , breast ductal carcinoma ( 3 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:	breast ( 3 ) , BT-20 (breast cell) ( 4 ) , Calu 6 (pulmonary) ( 4 ) , COS (fibroblast) ( 6 ) , H2009 (pulmonary) ( 4 ) , H2077 (pulmonary) ( 4 ) , H2887 (pulmonary) ( 4 ) , H322M (pulmonary) ( 4 ) , HeLa (cervical) ( 2 ) , MDA-MB-468 (breast cell) ( 4 ) , NCI-H1648 (pulmonary) ( 4 ) , WM239A (melanocyte) ( 1 )

Upstream Regulation
Treatments:	ischemia ( 3 )

References
1	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
4	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
5	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
6	Wang Y, et al. (2007) Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A 104, 8328-33 17494752 Curated Info