Tyr986
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Home > Phosphorylation Site Page: > Tyr986  -  LEPR (human)

Site Information
QRQPFVKyATLISNS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448435

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , liver cancer ( 4 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on biological processes:
translation, induced ( 3 )

References 

1

Uchiyama T, et al. (2011) Leptin receptor is involved in STAT3 activation in human colorectal adenoma. Cancer Sci 102, 367-72
21166956   Curated Info

2

Ohba S, Lanigan TM, Roessler BJ (2010) Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18, 1620-9
20868760   Curated Info

3

Gong Y, et al. (2007) The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem 282, 31019-27
17726024   Curated Info

4

Uotani S, Abe T, Yamaguchi Y (2006) Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway. Biochem Biophys Res Commun 351, 171-5
17054914   Curated Info