Thr634

Site Information
ENFDRFFtRHPPVLt SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448592

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	brain ( 1 , 2 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:	Sin1 (human) ( 1 )
Putative in vivo kinases:	mTOR (mouse) ( 1 )
Kinases, in vitro:	mTOR (mouse) ( 1 )
Treatments:	Torin1 ( 1 )

Downstream Regulation
Effects of modification on PKCB iso2:	enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein conformation ( 1 )
Inhibit interaction with:	PKCB iso2 (mouse) ( 1 )

References
1	Baffi TR, et al. (2021) mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal 14 33850054 Curated Info
2	Zhou J (2008) CST Curation Set: 4863; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: Phospho-Thr-Pro Motif Antibody (polyAB) Cat#: 3003, PTMScan(R) Phospho-Thr-Pro Motif (T*P) Immunoaffinity Beads Cat#: 1996 Curated Info

References

Baffi TR, et al. (2021) mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal 14
33850054 Curated Info

Zhou J (2008) CST Curation Set: 4863; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: Phospho-Thr-Pro Motif Antibody (polyAB) Cat#: 3003, PTMScan(R) Phospho-Thr-Pro Motif (T*P) Immunoaffinity Beads Cat#: 1996
Curated Info