Lys185
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Home > Acetylation Site Page: > Lys185  -  GOT2 (human)

Site Information
GYRYYDPkTCGFDFT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 466484

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on GOT2:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )
Induce interaction with:
MDH2 (human) ( 1 )

References 

1

Yang H, et al. (2015) SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J 34, 1110-25
25755250   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info