Lys159
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Home > Acetylation Site Page: > Lys159  -  GOT2 (human)

Site Information
SRDVFLPkPtWGNHt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 466485

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 5 , 6 , 7 , 8 , 9 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 5 , 6 , 7 ) , chronic myelogenous leukemia ( 5 , 6 , 7 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 2 , 8 ) , adipose tissue ( 1 ) , E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 3 ) , Jurkat (T lymphocyte) ( 8 ) , K562 (erythroid) ( 5 , 6 , 7 ) , liver ( 1 ) , MV4-11 (macrophage) ( 8 ) , PANC-1 (pancreatic) ( 1 )

Upstream Regulation
Treatments:
fasting ( 1 ) , glucose ( 1 ) , glutamine ( 1 ) , nicotinamide ( 1 ) , NMN ( 1 ) , siRNA ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on GOT2:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )
Induce interaction with:
MDH2 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
pancreatic carcinoma ( 1 )

References 

1

Yang H, et al. (2015) SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J 34, 1110-25
25755250   Curated Info

2

Wu Q, et al. (2015) Suberoylanilide hydroxamic acid treatment reveals crosstalks among proteome, ubiquitylome and acetylome in non-small cell lung cancer A549 cell line. Sci Rep 5, 9520
25825284   Curated Info

3

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Moritz A (2010) CST Curation Set: 9921; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

6

Moritz A (2010) CST Curation Set: 9920; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

7

Moritz A (2010) CST Curation Set: 9818; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

8

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

9

Li Y (2008) CST Curation Set: 4646; Year: 2008; Biosample/Treatment: tissue, colon/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989
Curated Info