Ser430

Site Information
DTLtPPPsDAGsPFQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 467201

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 2 , 3 )

Downstream Regulation
Effects of modification on SREBP-1:	molecular association, regulation ( 3 ) , phosphorylation ( 2 ) , protein degradation ( 1 , 3 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	transcription, induced ( 3 )
Induce interaction with:	FBXW7 (human) ( 3 )

References
1	Liu L, et al. (2016) Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth. Cancer Res 76, 1260-72 26759235 Curated Info
2	Bengoechea-Alonso MT, Ericsson J (2009) A Phosphorylation Cascade Controls the Degradation of Active SREBP1. J Biol Chem 284, 5885-95 19126544 Curated Info
3	Punga T, Bengoechea-Alonso MT, Ericsson J (2006) Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 281, 25278-86 16825193 Curated Info