Ser430
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Home > Phosphorylation Site Page: > Ser430  -  SREBP-1 (human)

Site Information
DTLtPPPsDAGsPFQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467201

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 3 )
Kinases, in vitro:
GSK3B (human) ( 3 )
Treatments:
DNA_binding ( 2 , 3 )

Downstream Regulation
Effects of modification on SREBP-1:
molecular association, regulation ( 3 ) , phosphorylation ( 2 ) , protein degradation ( 1 , 3 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 3 )
Induce interaction with:
FBXW7 (human) ( 3 )

References 

1

Liu L, et al. (2016) Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth. Cancer Res 76, 1260-72
26759235   Curated Info

2

Bengoechea-Alonso MT, Ericsson J (2009) A Phosphorylation Cascade Controls the Degradation of Active SREBP1. J Biol Chem 284, 5885-95
19126544   Curated Info

3

Punga T, Bengoechea-Alonso MT, Ericsson J (2006) Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 281, 25278-86
16825193   Curated Info