Thr426
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Home > Phosphorylation Site Page: > Thr426  -  SREBP-1 (human)

Site Information
TEVEDTLtPPPsDAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467200

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , immunoprecipitation ( 1 , 4 ) , mass spectrometry ( 1 , 2 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 5 ) , western blotting ( 1 , 3 , 4 )
Disease tissue studied:
liver cancer ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , HEK293T (epithelial) ( 4 , 5 ) , HeLa (cervical) ( 2 ) , hepatic ( 3 ) , HepG2 (hepatic) ( 3 )

Upstream Regulation
Regulatory protein:
MKK3 (human) ( 3 )
Putative in vivo kinases:
GSK3B (human) ( 5 ) , P38A (human) ( 3 )
Kinases, in vitro:
GSK3B (human) ( 5 ) , P38A (human) ( 3 ) , P38B (human) ( 3 ) , P38G (human) ( 3 )
Treatments:
DNA_binding ( 4 , 5 )

Downstream Regulation
Effects of modification on SREBP-1:
molecular association, regulation ( 5 ) , phosphorylation ( 4 ) , protein degradation ( 1 , 5 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 3 , 5 )
Induce interaction with:
FBXW7 (human) ( 5 )

References 

1

Liu L, et al. (2016) Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth. Cancer Res 76, 1260-72
26759235   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Kotzka J, et al. (2012) Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity. PLoS One 7, e32609
22384276   Curated Info

4

Bengoechea-Alonso MT, Ericsson J (2009) A Phosphorylation Cascade Controls the Degradation of Active SREBP1. J Biol Chem 284, 5885-95
19126544   Curated Info

5

Punga T, Bengoechea-Alonso MT, Ericsson J (2006) Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 281, 25278-86
16825193   Curated Info

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