Tyr493
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr493  -  CEACAM1 (human)

Site Information
NKMNEVtysTLNFEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447777

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 4 , 5 ) , phospho-antibody ( 1 , 5 ) , western blotting ( 1 )
Disease tissue studied:
gastric cancer ( 3 ) , gastric carcinoma ( 3 ) , liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 2 )
Putative upstream phosphatases:
SHP-2 (human) ( 1 )
Treatments:
KN-93 ( 1 ) , LY294002 ( 1 ) , SKI-606 ( 1 )

Downstream Regulation
Effects of modification on CEACAM1:
molecular association, regulation ( 4 )
Induce interaction with:
ITGB3 (human) ( 4 )

References 

1

Chean J, et al. (2021) Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. J Biol Chem 297, 101311
34666041   Curated Info

2

Hu W, et al. (2021) Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin. J Biol Chem 297, 101305
34656562   Curated Info

3

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

4

Brümmer J, et al. (2001) cis Interaction of the cell adhesion molecule CEACAM1 with integrin beta(3). Am J Pathol 159, 537-46
11485912   Curated Info

5

Estrera VT, et al. (2001) Signal transduction by the CEACAM1 tumor suppressor. Phosphorylation of serine 503 is required for growth-inhibitory activity. J Biol Chem 276, 15547-53
11278391   Curated Info