Ser67
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Home > Phosphorylation Site Page: > Ser67  -  PPP1R1A (rat)

Site Information
LKSTLsMsPRQRKKM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447758

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , 'muscle, skeletal' ( 3 ) , 'neuron, cortical'-brain ( 4 ) , adipose tissue ( 1 ) , heart ( 1 , 2 ) , intestine ( 1 ) , kidney ( 1 , 3 ) , muscle ( 1 ) , myocyte-heart ( 2 ) , pancreas ( 1 ) , PC-12 (chromaffin) ( 4 ) , spleen ( 1 )

Upstream Regulation
Regulatory protein:
PKCA (human) ( 2 )
Kinases, in vitro:
CDK5 (human) ( 3 , 4 ) , PKCA (human) ( 4 )
Treatments:
calyculin_A ( 4 ) , ciclosporin ( 2 ) , ischemia ( 2 ) , okadaic_acid ( 4 )

Downstream Regulation
Effects of modification on PPP1R1A:
activity, inhibited ( 2 ) , phosphorylation ( 2 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Shintani-Ishida K, Yoshida K (2011) Ischemia induces phospholamban dephosphorylation via activation of calcineurin, PKC-α, and protein phosphatase 1, thereby inducing calcium overload in reperfusion. Biochim Biophys Acta 1812, 743-51
21447388   Curated Info

3

Nguyen C, et al. (2007) Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem 282, 16511-20
17400554   Curated Info

4

Sahin B, et al. (2006) Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. J Biol Chem 281, 24322-35
16772299   Curated Info