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Site Information |
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DQGsLCTsFVGTLQY SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447779 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
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Downstream Regulation | |
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Effects of modification on IKKA: | |
Effects of modification on biological processes: |
References | |
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Loh JT, et al. (2023) DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11. Sci Signal 16, eadg5171
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Alquraishi M, et al. (2022) Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin. Cell Commun Signal 20, 76
35637461 Curated Info |
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Du Z, et al. (2022) Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF. Cell Death Differ
35449211 Curated Info |
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Ahmed AU, et al. (2017) Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis. J Immunol
28794235 Curated Info |
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Wu Z, et al. (2014) Calpain-1 contributes to IgE-mediated mast cell activation. J Immunol 192, 5130-9
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Sarkar S, et al. (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43, 19-32
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Chandrakesan P, et al. (2010) Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem 285, 33485-98
20710027 Curated Info |
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McPherson VA, et al. (2009) SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. J Immunol 183, 4940-7
19786542 Curated Info |
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Encinas M, et al. (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15, 1510-21
18497757 Curated Info |
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Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622 Curated Info |
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Ghosh S, et al. (2006) Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 10, 215-26
16959613 Curated Info |
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Chen BC, et al. (2006) Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B. J Immunol 177, 681-93
16785567 Curated Info |
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Wang Y, Xiang GS, Kourouma F, Umar S (2006) Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation. Br J Pharmacol 148, 814-24
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Hall G, et al. (2005) Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. Am J Physiol Heart Circ Physiol 289, H2103-11
15980040 Curated Info |
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Azoitei N, Wirth T, Baumann B (2005) Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem 93, 1487-501
15935065 Curated Info |
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Bhattacharyya S, et al. (2004) Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood 104, 1100-9
15113757 Curated Info |
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Gao Z, et al. (2004) Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 18, 2024-34
15143153 Curated Info |
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Saijo K, et al. (2002) Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. J Exp Med 195, 1647-52
12070292 Curated Info |