Ser180
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Home > Phosphorylation Site Page: > Ser180  -  IKKA (mouse)

Site Information
DQGsLCTsFVGTLQY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447779

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 , 10 , 13 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 3 ) , 'neuron, superior cervical ganglion' ( 6 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 14 ) , B lymphocyte-spleen ( 15 ) , BMMC (mast) ( 2 ) , bone marrow ( 13 ) , colon ( 1 , 4 , 10 ) , HeLa (cervical) ( 3 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 5 ) , MEF (fibroblast) ( 3 , 8 ) , myocyte-heart ( 11 ) , PC-12 (chromaffin) ( 12 ) , RAW 264.7 (macrophage) ( 9 ) , spleen ( 13 )

Upstream Regulation
Regulatory protein:
BRAF (human) ( 6 ) , ILK (mouse) ( 1 ) , SHP-2 (mouse) ( 5 ) , TSC2 (mouse) ( 8 )
Treatments:
anti-CD40 ( 13 , 15 ) , anti-IgE ( 5 ) , anti-IgM ( 15 ) , bacterial infection ( 4 , 10 ) , bortezomib ( 10 ) , cAMP_analog ( 9 ) , GDNF ( 6 ) , IL-10 ( 13 ) , KT5720 ( 9 ) , linoleic_acid ( 14 ) , LPS ( 11 , 13 ) , MMS ( 8 ) , NGF ( 6 , 12 ) , nitric_oxide ( 3 ) , NS398 ( 9 ) , PD98059 ( 4 ) , peptidoglycan ( 9 ) , PGE2 ( 9 ) , siRNA ( 6 ) , TNF ( 8 ) , U0126 ( 8 )

Downstream Regulation
Effects of modification on IKKA:
enzymatic activity, induced ( 12 )
Effects of modification on biological processes:
apoptosis, altered ( 6 ) , cell growth, altered ( 12 )

References 

1

Ahmed AU, et al. (2017) Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis. J Immunol
28794235   Curated Info

2

Wu Z, et al. (2014) Calpain-1 contributes to IgE-mediated mast cell activation. J Immunol 192, 5130-9
24760147   Curated Info

3

Sarkar S, et al. (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43, 19-32
21726807   Curated Info

4

Chandrakesan P, et al. (2010) Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem 285, 33485-98
20710027   Curated Info

5

McPherson VA, et al. (2009) SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. J Immunol 183, 4940-7
19786542   Curated Info

6

Encinas M, et al. (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15, 1510-21
18497757   Curated Info

7

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

8

Ghosh S, et al. (2006) Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 10, 215-26
16959613   Curated Info

9

Chen BC, et al. (2006) Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B. J Immunol 177, 681-93
16785567   Curated Info

10

Wang Y, Xiang GS, Kourouma F, Umar S (2006) Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation. Br J Pharmacol 148, 814-24
16751795   Curated Info

11

Hall G, et al. (2005) Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. Am J Physiol Heart Circ Physiol 289, H2103-11
15980040   Curated Info

12

Azoitei N, Wirth T, Baumann B (2005) Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem 93, 1487-501
15935065   Curated Info

13

Bhattacharyya S, et al. (2004) Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood 104, 1100-9
15113757   Curated Info

14

Gao Z, et al. (2004) Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 18, 2024-34
15143153   Curated Info

15

Saijo K, et al. (2002) Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. J Exp Med 195, 1647-52
12070292   Curated Info