Ser36
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Home > Phosphorylation Site Page: > Ser36  -  IkB-alpha (rat)

Site Information
RHDsGLDsMKDEDyE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448204

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 5 ) , western blotting ( 5 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 )
Relevant cell line - cell type - tissue:
intestine ( 5 ) , PC-12 (chromaffin) ( 4 )

Upstream Regulation
Kinases, in vitro:
IKKB (rat) ( 2 ) , p90RSK (rat) ( 2 )
Treatments:
Bay_11-7085 ( 5 ) , ischemia/reperfusion ( 5 )

Downstream Regulation
Effects of modification on IkB-alpha:
activity, induced ( 4 )
Effects of modification on biological processes:
apoptosis, altered ( 3 ) , transcription, altered ( 4 )

References 

1

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

2

Xu S, Bayat H, Hou X, Jiang B (2006) Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta. Am J Physiol Cell Physiol 291, C1336-45
16822942   Curated Info

3

Toruner M, et al. (2006) Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. J Biol Chem 281, 8686-96
16407217   Curated Info

4

Chen YL, Law PY, Loh HH (2006) Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression. J Biol Chem 281, 3067-74
16316997   Curated Info

5

Zou L, Attuwaybi B, Kone BC (2003) Effects of NF-kappa B inhibition on mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 284, G713-21
12466147   Curated Info