Tyr517
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Home > Phosphorylation Site Page: > Tyr517  -  ITK (mouse)

Site Information
RFVLDDQyTSSTGTK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447997

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
brain ( 2 ) , Jurkat (T lymphocyte) ( 3 ) , SF9 ( 3 ) , T lymphocyte-blood ( 3 ) , T lymphocyte-lymph node ( 1 )

Upstream Regulation
Putative in vivo kinases:
Lck (mouse) ( 3 )
Treatments:
anti-CD3 ( 3 )

Downstream Regulation
Effects of modification on ITK:
enzymatic activity, induced ( 3 ) , phosphorylation ( 3 )

References 

1

Iwai LK, Benoist C, Mathis D, White FM (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res 9, 3135-45
20438120   Curated Info

2

Zhou J (2009) CST Curation Set: 7383; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: QXp[ST]
Curated Info

3

Wilcox HM, Berg LJ (2003) Itk phosphorylation sites are required for functional activity in primary T cells. J Biol Chem 278, 37112-21
12842872   Curated Info