Tyr307
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Home > Phosphorylation Site Page: > Tyr307  -  PPP2CA (mouse)

Site Information
VTRRtPDyFl_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448571

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 3 ) , immunoassay ( 4 ) , immunoprecipitation ( 2 , 3 ) , mutation of modification site ( 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 11 , 13 , 14 , 15 , 16 , 17 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 11 , 13 , 14 , 15 , 16 )
Disease tissue studied:
Alzheimer's disease ( 4 , 17 ) , breast cancer ( 16 ) , neuroblastoma ( 1 , 8 , 13 , 17 ) , Lafora disease ( 15 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 , 11 ) , 'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 11 ) , 'neuron, hippocampal'-brain ( 11 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 4 ) , 293 (epithelial) ( 5 , 11 ) , 3T3 (fibroblast) ( 17 ) , 4T1 (breast cell) ( 16 ) , brain ( 17 ) , brain [laforin (mouse), homozygous knockout] ( 15 ) , COS (fibroblast) ( 15 ) , kidney ( 5 ) , lung [GPX1 (mouse), homozygous knockout] ( 9 ) , lymphocyte ( 3 ) , mast-bone marrow ( 2 ) , muscle [laforin (mouse), homozygous knockout] ( 15 ) , myocyte-heart ( 7 ) , Neuro-2a (neuron) ( 8 , 13 , 17 ) , retina ( 14 ) , SKNSH (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
Fyn (human) ( 2 ) , GPX1 (human) ( 9 ) , IRS1 (human) ( 7 ) , IRS2 (human) ( 7 ) , laforin (mouse) ( 15 ) , NMNAT2 (mouse) ( 11 ) , SET (mouse) ( 3 ) , SNCA (human) ( 6 )
Putative in vivo kinases:
LYN (mouse) ( 2 )
Putative upstream phosphatases:
PTP1B (mouse) ( 17 )
Phosphatases, in vitro:
PTP1B (human) ( 17 )
Treatments:
AAPH ( 5 ) , adiponectin ( 16 ) , anti-CD3 ( 3 ) , berberine ( 8 ) , beta-amyloid_25-35 ( 17 ) , C2-ceramide ( 1 ) , calyculin_A ( 8 , 13 ) , ceramide ( 3 ) , cigarette_smoke ( 9 ) , exercise training ( 7 ) , insulin ( 7 ) , LPS ( 2 ) , melatonin ( 13 ) , okadaic_acid ( 17 ) , olfactory bulbectomy ( 4 ) , peptide_antagonist ( 17 ) , PP2 ( 2 ) , rotenone ( 1 ) , serum ( 17 ) , siRNA ( 11 , 17 ) , SKI-606 ( 1 ) , sphingomyelinase ( 3 )

Downstream Regulation
Effects of modification on PPP2CA:
activity, inhibited ( 11 ) , enzymatic activity, induced ( 9 ) , enzymatic activity, inhibited ( 2 , 5 , 7 , 17 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 17 )

References 

1

Wang Y, et al. (2016) The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity. Int J Biochem Cell Biol 75, 34-44
27012437   Curated Info

2

Martín-Ávila A, et al. (2016) Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion. J Immunol 196, 5075-88
27183589   Curated Info

3

Apostolidis SA, et al. (2016) Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol 17, 556-64
26974206   Curated Info

4

Li K, et al. (2016) Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol 53, 391-401
25465240   Curated Info

5

Jung KJ, et al. (2015) Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance. J Mol Med (Berl) 93, 343-56
25394676   Curated Info

6

Hua G, et al. (2015) Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by α-Synuclein. Neurochem Res 40, 428-37
25567480   Curated Info

7

Riehle C, et al. (2014) Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol 34, 3450-60
25002528   Curated Info

8

Liu X, et al. (2014) Berberine attenuates axonal transport impairment and axonopathy induced by calyculin a in n2a cells. PLoS One 9, e93974
24713870   Curated Info

9

Geraghty P, et al. (2013) The Glutathione Peroxidase 1-Protein Tyrosine Phosphatase 1B-Protein Phosphatase 2A Axis. A Key Determinant of Airway Inflammation and Alveolar Destruction. Am J Respir Cell Mol Biol 49, 721-30
23590304   Curated Info

10

Sánchez I, et al. (2013) A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1. Hum Mol Genet 22, 3425-37
23630944   Curated Info

11

Cheng XS, et al. (2013) Nmnat2 attenuates Tau phosphorylation through activation of PP2A. J Alzheimers Dis 36, 185-95
23579329   Curated Info

12

Liu XP, et al. (2012) Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice. Glia 60, 1279-88
22729898   Curated Info

13

Xiong YF, et al. (2011) Melatonin reduces the impairment of axonal transport and axonopathy induced by calyculin A. J Pineal Res 50, 319-27
21244478   Curated Info

14

Finnegan S, Mackey AM, Cotter TG (2010) A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A. Eur J Neurosci 32, 322-34
20636478   Curated Info

15

Puri R, Suzuki T, Yamakawa K, Ganesh S (2009) Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. J Biol Chem 284, 22657-63
19542233   Curated Info

16

Kim KY, et al. (2009) Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 69, 4018-26
19366811   Curated Info

17

Liu R, et al. (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12, 241-57
18208556   Curated Info