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Site Information |
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VTRRtPDyFl_____ SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448571 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on PPP2CA: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
Disease / Diagnostics Relevance | |
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Relevant diseases: |
References | |
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Jiang TY, et al. (2023) PTEN deficiency facilitates gemcitabine efficacy in cancer by modulating the phosphorylation of PP2Ac and DCK. Sci Transl Med 15, eadd7464
37437018 Curated Info |
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Eteläinen TS, et al. (2023) A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Sci Transl Med 15, eabq2915
37043557 Curated Info |
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Sontag JM, et al. (2022) A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation. J Biol Chem 298, 102248
35820485 Curated Info |
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Kim B, et al. (2022) Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis. Sci Signal 15, eabi7400
35015571 Curated Info |
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Frohner IE, et al. (2020) PP2A Phospho-Tyr Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2A Modifications Including Leu Methylation. Cell Rep 30, 3171-3182.e6
32130916 Curated Info |
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Mazhar S, et al. (2020) Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr on PP2Ac. Cell Rep 30, 3164-3170.e3
32130915 Curated Info |
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Frohner IE, et al. (2020) Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition. Sci Signal 13
31992581 Curated Info |
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Huang P, et al. (2017) HEK293 cells exposed to microcystin-LR show reduced protein phosphatase 2A activity and more stable cytoskeletal structure when overexpressing α4 protein. Environ Toxicol 32, 255-264
26784437 Curated Info |
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Smith AM, et al. (2016) Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget 7, 47465-47478
27329844 Curated Info |
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Kobayashi Y, et al. (2016) Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity. Respir Res 17, 30
27013170 Curated Info |
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Du TT, et al. (2015) GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 11, 1803-20
26378614 Curated Info |
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Zonta F, et al. (2015) Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A. Blood 125, 3747-55
25931585 Curated Info |
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Rincón R, et al. (2015) PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects. Oncotarget 6, 4299-314
25726524 Curated Info |
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Sun Y, et al. (2014) Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line. Environ Toxicol 29, 1236-44
23436320 Curated Info |
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Preuss KD, et al. (2014) Inactivation of protein-phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits. Int J Cancer 135, 2046-53
24676687 Curated Info |
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Cristóbal I, et al. (2014) Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation. Biochim Biophys Acta 1842, 1823-9
24997451 Curated Info |
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Cristóbal I, et al. (2014) Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer. Br J Cancer 111, 756-62
25003662 Curated Info |
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Arif M, et al. (2014) Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A 111, 1144-9
24395787 Curated Info |
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Nardi F, et al. (2014) Enhanced Insulin Sensitivity Associated with Provision of Mono and Polyunsaturated Fatty Acids in Skeletal Muscle Cells Involves Counter Modulation of PP2A. PLoS One 9, e92255
24632852 Curated Info |
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Oaks JJ, et al. (2013) Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood 122, 1923-34
23926298 Curated Info |
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Cao Z, et al. (2013) X-linked Inhibitor of Apoptosis Protein (XIAP) Regulation of Cyclin D1 Protein Expression and Cancer Cell Anchorage-independent Growth via Its E3 Ligase-mediated Protein Phosphatase 2A/c-Jun Axis. J Biol Chem 288, 20238-47
23720779 Curated Info |
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Luo Y, et al. (2013) PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta 1833, 1235-43
23428800 Curated Info |
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Piazza R, et al. (2013) Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet 45, 18-24
23222956 Curated Info |
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Samuel GH, et al. (2012) Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis. J Dermatol Sci 67, 166-72
22771321 Curated Info |
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Torrent L, Ferrer I (2012) PP2A and Alzheimer disease. Curr Alzheimer Res 9, 248-56
22299660 Curated Info |
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Woo CW, Kutzler L, Kimball SR, Tabas I (2012) Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B. Nat Cell Biol 14, 192-200
22231169 Curated Info |
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Irie A, Harada K, Araki N, Nishimura Y (2012) Phosphorylation of SET Protein at Ser171 by Protein Kinase D2 Diminishes Its Inhibitory Effect on Protein Phosphatase 2A. PLoS One 7, e51242
23251465 Curated Info |
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Preuss KD, et al. (2011) Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A. Blood 118, 3340-6
21791414 Curated Info |
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Yao XQ, et al. (2011) Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochem J 437, 335-44
21554241 Curated Info |
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Stanevich V, et al. (2011) The structural basis for tight control of PP2A methylation and function by LCMT-1. Mol Cell 41, 331-42
21292165 Curated Info |
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Wong LL, Zhang D, Chang CF, Koay ES (2010) Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis. Exp Cell Res 316, 3387-96
20558158 Curated Info |
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Cheng G, et al. (2010) Basis for MAP4 Dephosphorylation-related Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy. J Biol Chem 285, 38125-40
20889984 Curated Info |
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Barisic S, Schmidt C, Walczak H, Kulms D (2010) Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2A. Biochem Pharmacol 80, 439-47
20450893 Curated Info |
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Finnegan S, Mackey AM, Cotter TG (2010) A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A. Eur J Neurosci 32, 322-34
20636478 Curated Info |
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De Toni-Costes F, et al. (2010) A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells. PLoS One 5, e9807
20352103 Curated Info |
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Kim KY, et al. (2009) Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 69, 4018-26
19366811 Curated Info |
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Liu R, et al. (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12, 241-57
18208556 Curated Info |
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Longin S, et al. (2007) Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem 282, 26971-80
17635907 Curated Info |
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Nunbhakdi-Craig V, et al. (2007) Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules. J Neurochem 101, 959-71
17394530 Curated Info |
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Zhu D, et al. (2007) Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A? Mol Pharmacol 71, 1268-76
17303700 Curated Info |
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Li X, Schwacha MG, Chaudry IH, Choudhry MA (2006) A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury. J Leukoc Biol 79, 453-62
16387841 Curated Info |
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Neviani P, et al. (2005) The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 8, 355-68
16286244 Curated Info |
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Yokoyama N, Reich NC, Miller WT (2003) Determinants for the interaction between Janus kinase 2 and protein phosphatase 2A. Arch Biochem Biophys 417, 87-95
12921784 Curated Info |
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Evans DR, Hemmings BA (2000) Important role for phylogenetically invariant PP2Acalpha active site and C-terminal residues revealed by mutational analysis in Saccharomyces cerevisiae. Genetics 156, 21-9
10978272 Curated Info |
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Chen J, Martin BL, Brautigan DL (1992) Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257, 1261-4
1325671 Curated Info |