|
Powered by Cell Signaling Technology |
Site Information |
---|
RALNRQLssGVsEIR SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448403 |
In vivo Characterization | |
---|---|
Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
---|---|
Kinases, in vitro: | |
Treatments: |
Downstream Regulation | |
---|---|
Effects of modification on HSP27: | |
Effects of modification on biological processes: |
References | |
---|---|
Wang N, et al. (2023) Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway. iScience 26, 107443
37575200 Curated Info |
|
Miskiewicz EI, Olaloku A, MacPhee BK, MacPhee DJ (2022) Phosphoserine-86-HSPB1 (pS86-HSPB1) is cytoplasmic and highly induced in rat myometrium at labour. Histochem Cell Biol
36260112 Curated Info |
|
Matsuo K, et al. (2021) Geranylgeranylacetone attenuates cerebral ischemia-reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study. BMC Neurosci 22, 9
33557752 Curated Info |
|
Schmidt T, et al. (2016) Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in the rat retina upon optic nerve injury. Cell Stress Chaperones 21, 167-78
26475352 Curated Info |
|
Reddy VS, Kumar ChU, Raghu G, Reddy GB (2014) Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys 558, 1-9
24950024 Curated Info |
|
Moreno-Domínguez A, et al. (2014) Cytoskeletal Reorganization Evoked by Rho-associated kinase- and Protein Kinase C-catalyzed Phosphorylation of Cofilin and Heat Shock Protein 27, Respectively, Contributes to Myogenic Constriction of Rat Cerebral Arteries. J Biol Chem 289, 20939-20952
24914207 Curated Info |
|
Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903 Curated Info |
|
Clements RT, et al. (2011) p38 MAPK-dependent small HSP27 and αB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest. Am J Physiol Heart Circ Physiol 300, H1669-77
21357508 Curated Info |
|
Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781 Curated Info |
|
Huang SY, et al. (2007) A systematic MS-based approach for identifying in vitro substrates of PKA and PKG in rat uteri. J Proteome Res 6, 2674-84
17564427 Curated Info |
|
Venkatakrishnan CD, et al. (2006) Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27. Am J Physiol Heart Circ Physiol 291, H2680-91
16782845 Curated Info |
|
Hoffert JD, et al. (2006) Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103, 7159-64
16641100 Curated Info |
|
Huang SY, et al. (2006) Quantitation of protein phosphorylation in pregnant rat uteri using stable isotope dimethyl labeling coupled with IMAC. Proteomics 6, 1722-34
16470654 Curated Info |
|
Akamatsu S, et al. (2004) Vasopressin phosphorylates HSP27 in aortic smooth muscle cells. J Cell Biochem 92, 1203-11
15258903 Curated Info |
|
Kato K, et al. (2002) Innervation-dependent phosphorylation and accumulation of alphaB-crystallin and Hsp27 as insoluble complexes in disused muscle. FASEB J 16, 1432-4
12205038 Curated Info |
|
Eaton P, Fuller W, Shattock MJ (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. J Biol Chem 277, 21189-96
11925435 Curated Info |