Ser1039
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Home > Phosphorylation Site Page: > Ser1039  -  PIK3CD (human)

Site Information
NWLAHNVsKDNRQ__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 466429

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 , 8 ) , western blotting ( 8 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , leukemia ( 6 ) , acute myelogenous leukemia ( 6 ) , mastocytoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Kit (human) ( 2 )
Kinases, in vitro:
PIK3CD (human) ( 8 )
Treatments:
B7 ( 8 ) , dasatinib ( 2 ) , LY294002 ( 8 ) , okadaic_acid ( 8 ) , wortmannin ( 8 )

Downstream Regulation
Effects of modification on PIK3CD:
enzymatic activity, inhibited ( 8 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , carcinogenesis, induced ( 2 ) , cell growth, induced ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Sun J, et al. (2014) The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner. Oncogene 33, 5360-5369
24213578   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
22115753   Curated Info

7

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

8

Vanhaesebroeck B, et al. (1999) Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J 18, 1292-302
10064595   Curated Info