Thr778
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Home > Phosphorylation Site Page: > Thr778  -  PKN1 (rat)

Site Information
GYGDRtStFCGTPEF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447835

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
adrenal cancer ( 1 , 2 ) , pheochromocytoma ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PKN1 (rat) ( 4 )
Treatments:
TGF-beta ( 3 )

References 

1

Zhou J (2009) CST Curation Set: 6823; Year: 2009; Biosample/Treatment: cell line, PC-12/forskolin; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RRXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info

2

Zhou J (2009) CST Curation Set: 6822; Year: 2009; Biosample/Treatment: cell line, PC-12/untreated; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RRXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info

3

Su C, et al. (2007) PKN activation via transforming growth factor-beta 1 (TGF-beta 1) receptor signaling delays G2/M phase transition in vascular smooth muscle cells. Cell Cycle 6, 739-49
17374997   Curated Info

4

Peng B, Morrice NA, Groenen LC, Wettenhall RE (1996) Phosphorylation events associated with different states of activation of a hepatic cardiolipin/protease-activated protein kinase. Structural identity to the protein kinase N-type protein kinases. J Biol Chem 271, 32233-40
8943281   Curated Info