Lys378
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Home > Acetylation Site Page: > Lys378  -  SMAD3 (human)

Site Information
TIRMSFVkGWGAEYR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 466353

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 4 ) , modification-specific antibody ( 5 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
liver cancer ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
TGF-beta ( 5 )

Downstream Regulation
Effects of modification on SMAD3:
activity, induced ( 5 )
Effects of modification on biological processes:
transcription, induced ( 5 )

References 

1

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

5

Inoue Y, et al. (2007) Smad3 is acetylated by p300/CBP to regulate its transactivation activity. Oncogene 26, 500-8
16862174   Curated Info