Ser871
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Home > Phosphorylation Site Page: > Ser871  -  HMGCR (rat)

Site Information
SHMVHNRsKINLQDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448568

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
hepatocyte-liver ( 1 ) , liver ( 3 )

Upstream Regulation
Kinases, in vitro:
CAMK1A (rat) ( 2 ) , PKACA (rat) ( 1 , 3 ) , PKCA (rat) ( 2 )
Treatments:
fructose ( 1 )

Downstream Regulation
Effects of modification on HMGCR:
enzymatic activity, inhibited ( 3 )

References 

1

Gillespie JG, Hardie DG (1992) Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes. FEBS Lett 306, 59-62
1628744   Curated Info

2

Clarke PR, Hardie DG (1990) Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase. FEBS Lett 269, 213-7
2387404   Curated Info

3

Clarke PR, Hardie DG (1990) Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 9, 2439-46
2369897   Curated Info