Ser863
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Home > Phosphorylation Site Page: > Ser863  -  GluR1 (human)

Site Information
TStLPRNsGAGASSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448566

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 , 6 , 7 , 8 , 9 ) , western blotting ( 2 , 3 , 6 , 7 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 3 ) , 'neuron, cortical'-brain ( 2 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 7 ) , 'neuron, striatal'-brain ( 6 ) , 293 (epithelial) ( 7 ) , cochlea ( 8 ) , HEK293T (epithelial) ( 3 )

Upstream Regulation
Regulatory protein:
CAMK2A (human) ( 3 )
Putative in vivo kinases:
PKACA (human) ( 8 )
Treatments:
ciclosporin ( 3 ) , colforsin ( 2 ) , glycine ( 3 ) , learning ( 3 ) , levodopa ( 6 ) , MPTP ( 6 ) , NKH_477 ( 3 ) , okadaic_acid ( 3 ) , phorbol_ester ( 2 , 3 )

Downstream Regulation
Effects of modification on GluR1:
molecular association, regulation ( 2 ) , ubiquitination ( 2 )
Inhibit interaction with:
NEDD4 (human) ( 2 )

References 

1

Xu D, et al. (2021) Identification and Characterization of TF-lncRNA Regulatory Networks Involved in the Tumorigenesis and Development of Adamantinomatous Craniopharyngioma. Front Oncol 11, 739714
35155179   Curated Info

2

Guntupalli S, et al. (2017) GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem 292, 8186-8194
28377502   Curated Info

3

Hosokawa T, Mitsushima D, Kaneko R, Hayashi Y (2015) Stoichiometry and Phosphoisotypes of Hippocampal AMPA-Type Glutamate Receptor Phosphorylation. Neuron 85, 60-7
25533481   Curated Info

4

Murphy JA, et al. (2014) Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca2+ Signaling in Spines. J Neurosci 34, 869-79
24431445   Curated Info

5

Ribeiro LF, et al. (2014) Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Proc Natl Acad Sci U S A 111, E149-58
24367106   Curated Info

6

Santini E, et al. (2010) Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia. PLoS One 5, e12322
20808799   Curated Info

7

Tavalin SJ (2008) AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. J Biol Chem 283, 11445-52
18305116   Curated Info

8

Niu X, Canlon B (2006) The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea. Neuroscience 137, 981-90
16330149   Curated Info

9

Emamian ES, Karayiorgou M, Gogos JA (2004) Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia. J Neurosci 24, 1561-4
14973229   Curated Info