Lys131
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Home > Acetylation Site Page: > Lys131  -  CLIC1 (human)

Site Information
ALNDNLEkGLLkALk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 466245

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 5 , 6 , 7 , 8 ) , western blotting ( 1 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 5 ) , C-33A (cervical) ( 1 ) , HCerEpiC (cervical) ( 1 ) , HCT116 (intestinal) ( 6 ) , HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 3 , 5 ) , MV4-11 (macrophage) ( 5 ) , SiHa (squamous) ( 1 ) , SW620 (intestinal) ( 7 , 8 )

Downstream Regulation
Effects of modification on CLIC1:
protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
cervical cancer ( 1 )

References 

1

Wang W, et al. (2021) Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB. Cell Oncol (Dordr) 44, 557-568
33469837   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

6

Li Y (2006) CST Curation Set: 1262; Year: 2006; Biosample/Treatment: cell line, HCT116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441
Curated Info

7

Li Y (2006) CST Curation Set: 1102; Year: 2006; Biosample/Treatment: cell line, SW620/serum starved; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441
Curated Info

8

Li Y (2006) CST Curation Set: 1103; Year: 2006; Biosample/Treatment: cell line, SW620/serum starved; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441
Curated Info

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