Ser327
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Home > Phosphorylation Site Page: > Ser327  -  PSEN2 (human)

Site Information
DPEMEEDsYDsFGEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448564

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phosphoamino acid analysis ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK1D (human) ( 2 )

Downstream Regulation
Effects of modification on PSEN2:
protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )

References 

1

Walter J, Schindzielorz A, Grünberg J, Haass C (1999) Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proc Natl Acad Sci U S A 96, 1391-6
9990034   Curated Info

2

Walter J, Grünberg J, Schindzielorz A, Haass C (1998) Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry 37, 5961-7
9558331   Curated Info