Tyr1008
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Home > Phosphorylation Site Page: > Tyr1008  -  JAK2 (rat)

Site Information
LPQDKEyyKVKEPGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448408

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 7 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 ) , western blotting ( 1 , 2 , 4 , 5 , 9 )
Disease tissue studied:
brain cancer ( 4 ) , glioma ( 4 ) , liver cancer ( 2 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-'heart, artery' ( 9 ) , C6 (glial) ( 4 ) , CHO-K1 (fibroblast) ( 4 ) , HepG2 (hepatic) ( 2 ) , IEC-6 (epithelial) ( 5 ) , myocyte-heart ( 6 ) , RAEC (endothelial) ( 3 ) , Sf21 ( 7 ) , VSMC ( 1 )

Upstream Regulation
Putative in vivo kinases:
Pyk2 (rat) ( 9 )
Treatments:
A23187 ( 9 ) , AG490 ( 3 , 4 ) , angiotensin ( 9 ) , BAPTA-AM ( 9 ) , BIM23926 ( 4 ) , CV11974 ( 9 ) , edelfosine ( 9 ) , eflornithine ( 5 ) , EGF ( 9 ) , G-CSF ( 6 ) , GF109203X ( 9 ) , Go_6976 ( 9 ) , leptin ( 2 ) , oxysterol ( 3 ) , phorbol_ester ( 9 ) , PP2 ( 5 ) , PRL ( 8 ) , PTX ( 4 ) , rottlerin ( 9 ) , somatostatin ( 4 ) , thrombin ( 9 ) , TMB8 ( 9 ) , TNF ( 5 )

Downstream Regulation
Effects of modification on JAK2:
enzymatic activity, induced ( 7 )

References 

1

Singh NK, et al. (2011) 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling. J Biol Chem 286, 22478-88
21536676   Curated Info

2

Knobelspies H, et al. (2010) Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem 11, 2
20059770   Curated Info

3

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

4

Arena S, et al. (2007) An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Mol Endocrinol 21, 229-46
17021051   Curated Info

5

Bhattacharya S, Ray RM, Johnson LR (2006) Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J 397, 437-47
16669788   Curated Info

6

Harada M, et al. (2005) G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11, 305-11
15723072   Curated Info

7

Chatti K, Farrar WL, Duhé RJ (2004) Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state. Biochemistry 43, 4272-83
15065871   Curated Info

8

Ali S, Nouhi Z, Chughtai N, Ali S (2003) SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J Biol Chem 278, 52021-31
14522994   Curated Info

9

Frank GD, et al. (2002) Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Mol Endocrinol 16, 367-77
11818507   Curated Info