Thr183
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Home > Phosphorylation Site Page: > Thr183  -  JNK1 (mouse)

Site Information
AGtsFMMtPyVVtRY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447643

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 64 ) , [32P] bio-synthetic labeling ( 94 ) , immunoassay ( 61 ) , immunoprecipitation ( 4 , 61 , 64 ) , mass spectrometry ( 2 , 3 , 4 , 7 , 12 , 14 , 15 , 16 , 17 , 24 , 36 , 38 , 39 , 40 , 42 , 44 , 45 , 48 , 51 , 53 , 55 , 56 , 57 , 58 , 62 , 67 , 68 , 83 ) , mutation of modification site ( 4 , 59 , 84 ) , peptide sequencing ( 33 ) , phospho-antibody ( 5 , 8 , 10 , 11 , 13 , 18 , 21 , 22 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 37 , 41 , 43 , 46 , 47 , 49 , 52 , 54 , 59 , 60 , 61 , 65 , 66 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 80 , 81 , 82 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ) , phosphopeptide mapping ( 94 ) , western blotting ( 4 , 5 , 8 , 10 , 11 , 13 , 18 , 21 , 22 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 41 , 43 , 47 , 49 , 52 , 54 , 59 , 60 , 61 , 65 , 66 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 82 , 84 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 94 , 95 )
Disease tissue studied:
kidney cancer ( 71 ) , leukemia ( 44 , 45 ) , liver cancer ( 4 ) , lung cancer ( 66 ) , lymphoma ( 78 ) , B cell lymphoma ( 78 ) , Burkitt's lymphoma ( 78 ) , neuroblastoma ( 24 , 28 ) , testicular cancer ( 39 ) , type 2 diabetes ( 41 ) , Turner-like syndrome ( 48 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 33 ) , 'brain, embryonic' ( 58 , 67 ) , 'brain, hippocampus' ( 69 ) , 'brain, striatum' ( 92 ) , 'muscle, skeletal' ( 86 ) , 'neuron, cortical'-brain ( 10 ) , 'renal, podocyte' ( 35 ) , 293 (epithelial) ( 8 , 49 , 61 , 78 , 94 ) , 32D (myeloid) [BCR-ABL1 (human), transfection] ( 37 ) , 32D (myeloid) [IRS1 (mouse)] ( 89 ) , 32D (myeloid) ( 46 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 42 ) , 32Dcl3 (myeloid) ( 42 ) , 3T3 (fibroblast) [INSR (human)] ( 94 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 91 ) , 3T3 (fibroblast) ( 18 ) , 3T3-L1 (fibroblast) ( 21 ) , adipocyte ( 75 ) , adipose tissue ( 64 ) , aorta ( 70 ) , B lymphocyte ( 78 ) , B lymphocyte-spleen ( 72 ) , BAEC (endothelial) ( 71 ) , BaF3 ('B lymphocyte, precursor') [JAK3 (human), transfection] ( 2 ) , BJAB (B lymphocyte) ( 78 ) , BMMC (mast) ( 32 ) , bone marrow ( 74 ) , brain ( 13 , 15 , 16 , 17 , 53 , 55 , 57 , 62 , 68 , 83 ) , COS (fibroblast) ( 90 ) , embryo ( 17 ) , ES (stem) ( 8 , 61 ) , FL5.12 (lymphoid) ( 85 ) , GD25 (fibroblast) ( 88 ) , heart ( 48 , 73 ) , HEK293T (epithelial) ( 5 ) , Hepa 1-6 (epithelial) ( 51 ) , HepG2 (hepatic) ( 4 ) , JB (epithelial) ( 93 ) , liver ( 4 , 17 ) , lung ( 66 ) , lung [GPX1 (mouse), homozygous knockout] ( 11 ) , macrophage-bone marrow ( 36 , 80 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 36 ) , macrophage-peritoneum ( 14 , 27 , 95 ) , mast-bone marrow ( 72 , 76 ) , mast-bone marrow [PTPRA (mouse), homozygous knockout] ( 52 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 43 ) , MEF (fibroblast) ( 12 , 59 , 64 , 65 , 73 , 77 , 84 , 93 ) , MEF (fibroblast) [DOK1 (mouse)] ( 60 ) , MEF (fibroblast) [IGF1R (mouse)] ( 81 ) , MEF (fibroblast) [JNK1 (mouse), transfection] ( 49 ) , MEF (fibroblast) [LKB1 (mouse)] ( 87 ) , MEF (fibroblast) [PKR (mouse), homozygous knockout] ( 31 , 41 ) , MEF (fibroblast) [Raptor (mouse), knockdown] ( 12 ) , MEF (fibroblast) [RICTOR (mouse), knockdown] ( 12 ) , microvessel-kidney ( 71 ) , mLEC (epithelial) ( 26 ) , MMTV-PyMT (breast cell) [JNK2 (mouse), homozygous knockout] ( 29 ) , myocyte-heart ( 30 , 73 ) , N1E-115 (neuron) ( 24 ) , Neuro-2a (neuron) ( 28 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 3 ) , P19 (testicular) ( 39 ) , PYS-2 (epithelial) ( 40 ) , Raji (B lymphocyte) ( 78 ) , RAW 264 (macrophage) ( 82 ) , RAW 264.7 (macrophage) ( 7 , 44 , 45 , 47 ) , skin ( 34 ) , stromal ( 23 ) , T lymphocyte [FOXO1A (mouse), transgenic] ( 22 ) , T lymphocyte-lymph node ( 72 ) , vascular smooth muscle cell ('muscle, smooth') ( 54 ) , WEHI-231 (B lymphocyte) ( 78 )

Upstream Regulation
Regulatory protein:
APC (human) ( 78 ) , ARHGEF4 (mouse) ( 78 ) , Bcl-10 (mouse) ( 72 ) , CARD11 (mouse) ( 72 ) , Cot (mouse) ( 81 ) , CTNNB1 (mouse) ( 49 ) , DUSP1 (mouse) ( 33 ) , DUSP19 (mouse) ( 90 ) , DUSP3 (mouse) ( 90 ) , eNOS (mouse) ( 75 ) , FOXP1 (mouse) ( 22 ) , Fyn (mouse) ( 5 ) , GAB2 (mouse) ( 76 ) , GPX1 (human) ( 11 ) , HGK (mouse) ( 73 ) , IGF1R (mouse) ( 85 ) , JNK1 (human) ( 49 ) , KHS1 (human) ( 78 ) , MEK1 (mouse) ( 61 ) , MEKK1 (mouse) ( 8 ) , PKR (mouse) ( 31 , 41 ) , PPP1CC (human) ( 54 ) , PXN (mouse) ( 79 ) , RHOA (mouse) ( 71 ) , ROCK1 (human) ( 63 ) , SHP-2 (mouse) ( 43 ) , Src (mouse) ( 18 ) , Syk (mouse) ( 71 ) , TAK1 (mouse) ( 73 )
Putative in vivo kinases:
MKK4 (mouse) ( 61 )
Kinases, in vitro:
MKK4 (mouse) ( 6 , 61 )
Treatments:
acadesine ( 87 ) , activin ( 61 ) , adriamycin ( 31 ) , AG1478 ( 35 ) , AG490 ( 8 ) , alpha-lipoic_acid ( 28 ) , anisomycin ( 21 , 95 ) , anti-CD3/CD28 ( 22 ) , anti-FcRII ( 71 ) , anti-IgE ( 43 ) , Aplidin ( 84 ) , benzo(a)pyrene ( 66 ) , black_tea_polyphenols ( 34 ) , bradykinin ( 75 ) , ciclopirox_olamine ( 26 ) , cigarette_smoke ( 11 ) , cisplatin ( 59 ) , cold_water_stress ( 69 ) , CRP ( 71 ) , cyclic_stretch ( 35 ) , DMNQ ( 54 ) , dronabinol ( 10 ) , DTT ( 33 ) , EGF ( 8 , 79 ) , ether ( 69 ) , fasting ( 4 ) , food deprivation ( 69 ) , glucose ( 21 , 30 , 35 ) , H2O2 ( 35 ) , HA-1077 ( 63 ) , hydroxylamine ( 75 ) , hypoxia ( 30 ) , hypoxia/reoxygenation ( 30 ) , IGF-1 ( 85 ) , IgG ( 80 ) , IL-1b ( 81 ) , IL-33 ( 7 ) , IL-6 ( 70 ) , imatinib ( 37 , 46 ) , inhibitor_IX ( 46 ) , insulin ( 21 , 75 , 89 , 94 ) , ionizing_radiation ( 46 , 59 ) , ionomycin ( 72 ) , JNK_inhibitor_I ( 70 ) , licochalcone_A ( 47 ) , licochalcone_B ( 47 ) , licochalcone_C ( 47 ) , licochalcone_D ( 47 ) , long-term_potentiation ( 3 ) , low_glucose ( 35 ) , LPA ( 24 ) , LPS ( 27 , 36 , 47 , 80 ) , LY294002 ( 89 ) , M-CSF ( 74 ) , metamfetamine ( 92 ) , mitomycin_C ( 59 ) , MK-591 ( 13 ) , muramyl_dipeptide ( 23 ) , NSC697923 ( 8 ) , NTCU ( 66 ) , okadaic_acid ( 95 ) , palmitate ( 18 , 64 ) , PD169316 ( 86 , 93 ) , PD98059 ( 70 , 86 , 89 , 93 ) , PGE2 ( 32 , 82 ) , phorbol_ester ( 34 , 72 , 79 , 95 ) , pomegranate_wine ( 66 ) , PP2 ( 85 ) , RAD001 ( 37 ) , RANKL ( 74 , 82 ) , rapamycin ( 5 , 32 ) , resveratrol ( 34 ) , SB202190 ( 93 ) , SCF ( 50 , 52 , 76 ) , serum ( 29 ) , serum_withdrawal ( 29 ) , sFRP-1 ( 78 ) , siRNA ( 71 , 79 ) , sorbitol ( 90 ) , SP600125 ( 21 , 28 , 37 , 60 , 85 , 86 ) , TAK1_inhibitor ( 8 ) , TGF-alpha ( 61 ) , TGF-beta ( 8 , 61 ) , thapsigargin ( 5 , 41 ) , TNF ( 65 , 74 , 81 , 86 ) , Torin1 ( 32 ) , tunicamycin ( 33 ) , U0126 ( 60 ) , UV ( 59 , 77 , 91 , 93 ) , WIN ( 10 ) , Wnt3a ( 78 ) , wortmannin ( 32 ) , Y27632 ( 71 ) , zymosan ( 95 )

Downstream Regulation
Effects of modification on JNK1:
enzymatic activity, induced ( 61 ) , molecular association, regulation ( 49 ) , protein degradation ( 49 )
Effects of modification on biological processes:
apoptosis, induced ( 5 ) , apoptosis, inhibited ( 34 ) , carcinogenesis, induced ( 34 ) , cell motility, induced ( 61 ) , transcription, altered ( 49 ) , transcription, inhibited ( 61 )
Induce interaction with:
CTNNB1 (human) ( 49 ) , GSK3B (human) ( 49 )

References 

1

Nakatsu D, Kano F, Shinozaki-Narikawa N, Murata M (2019) Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions. PLoS One 14, e0223300
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2

Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia
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3

Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8
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4

Zhao Y, et al. (2015) RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK. Cell Rep 13, 1407-17
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5

Wang Y, Yamada E, Zong H, Pessin JE (2015) Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death. J Biol Chem 290, 24772-83
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6

Yang J, et al. (2015) Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell 160, 161-76
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7

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
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8

Charlaftis N, et al. (2014) The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J 33, 2581-96
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9

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
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10

Tortoriello G, et al. (2014) Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J 33, 668-85
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11

Geraghty P, et al. (2013) The Glutathione Peroxidase 1-Protein Tyrosine Phosphatase 1B-Protein Phosphatase 2A Axis. A Key Determinant of Airway Inflammation and Alveolar Destruction. Am J Respir Cell Mol Biol 49, 721-30
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12

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
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13

Chu J, Lauretti E, Di Meco A, Praticò D (2013) FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo . Transl Psychiatry 3, e333
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14

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
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15

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
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16

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
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17

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
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18

Holzer RG, et al. (2011) Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147, 173-84
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19

Hatziapostolou M, et al. (2011) Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal 4, ra55
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20

Ryu JM, Han HJ (2011) L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways. J Biol Chem 286, 23667-78
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21

Gao Z, et al. (2011) Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 286, 22227-34
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22

Feng X, et al. (2011) Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol 12, 544-50
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23

Kim YG, et al. (2011) The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 34, 769-80
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24

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
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25

Bard-Chapeau EA, et al. (2011) Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19, 629-39
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26

Luo Y, et al. (2011) The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene 30, 2098-107
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27

Liu X, et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12, 416-24
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28

Wang X, et al. (2011) Essential role of ERK activation in neurite outgrowth induced by α-lipoic acid. Biochim Biophys Acta 1813, 827-38
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29

Mitra S, Lee JS, Cantrell M, Van den Berg CL (2011) c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8). J Biol Chem 286, 15287-97
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30

Wei J, et al. (2011) c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem 286, 13995-4006
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31

Peidis P, et al. (2011) Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death. Cell Death Differ 18, 145-54
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32

Kuehn HS, et al. (2011) Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. J Biol Chem 286, 391-402
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33

Li B, et al. (2011) Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1. Cell Signal 23, 35-45
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34

George J, et al. (2011) Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One 6, e23395
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35

Faour WH, Thibodeau JF, Kennedy CR (2010) Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes. Cell Signal 22, 1222-30
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36

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
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37

Mancini M, et al. (2010) mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein. Leuk Res 34, 641-8
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38

Zhou J (2010) CST Curation Set: 9104; Year: 2010; Biosample/Treatment: cell line, ES J1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

39

Zhou J (2010) CST Curation Set: 9109; Year: 2010; Biosample/Treatment: cell line, P19/untreated; Disease: testicular cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

40

Zhou J (2010) CST Curation Set: 9108; Year: 2010; Biosample/Treatment: cell line, PY2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

41

Nakamura T, et al. (2010) Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140, 338-48
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42

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
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43

McPherson VA, et al. (2009) SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. J Immunol 183, 4940-7
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44

Possemato A (2009) CST Curation Set: 7168; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

45

Possemato A (2009) CST Curation Set: 7167; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

46

Mancini M, et al. (2009) 14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia. Traffic 10, 637-47
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47

Furusawa J, et al. (2009) Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol 9, 499-507
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48

Stokes M (2008) CST Curation Set: 5666; Year: 2008; Biosample/Treatment: cell line, Noonan Syndrome mouse heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

49

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
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50

Simon C, et al. (2008) Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112, 4039-47
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51

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
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52

Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85
18725415   Curated Info

53

Guo A (2008) CST Curation Set: 5007; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) CDKs Substrate Antibody Cat#: 2324, PTMScan(R) Phospho-CDK Substrate Motif (K/RS*PXK/R) Immunoaffinity Beads Cat#: 1981
Curated Info

54

Tchivilev I, et al. (2008) Identification of a protective role for protein phosphatase 1cgamma1 against oxidative stress-induced vascular smooth muscle cell apoptosis. J Biol Chem 283, 22193-205
18540044   Curated Info

55

Zhou J (2008) CST Curation Set: 4784; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) CDKs Substrate Antibody Cat#: 2324, PTMScan(R) Phospho-CDK Substrate Motif (K/RS*PXK/R) Immunoaffinity Beads Cat#: 1981
Curated Info

56

Rikova K (2008) CST Curation Set: 4480; Year: 2008; Biosample/Treatment: cell line, MD Ander 1249/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

57

Zhou J (2008) CST Curation Set: 4322; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY
Curated Info

58

Zhou J (2008) CST Curation Set: 4323; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY
Curated Info

59

Yogev O, et al. (2008) DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway. Cancer Res 68, 1398-406
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60

Hosooka T, et al. (2008) Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med 14, 188-93
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61

Takatori A, et al. (2008) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development 135, 23-32
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62

Ballif BA, Carey GR, Sunyaev SR, Gygi SP (2008) Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res 7, 311-8
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63

Ongusaha PP, et al. (2008) Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal 1, ra14
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64

Jaeschke A, Davis RJ (2007) Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 27, 498-508
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65

Schlaepfer DD, et al. (2007) Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem 282, 17450-9
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66

Khan N, et al. (2007) Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res 67, 3475-82
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67

Guo A (2007) CST Curation Set: 2672; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

68

Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

69

Ikeda Y, Ishiguro K, Fujita SC (2007) Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain. FEBS Lett 581, 891-7
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70

Andreozzi F, et al. (2007) Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol 27, 2372-83
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71

Xu JW, et al. (2007) C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21, 564-73
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72

Blonska M, et al. (2007) The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity 26, 55-66
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73

Xie M, et al. (2006) A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A 103, 17378-83
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74

Huang H, et al. (2006) Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL. Cell Death Differ 13, 1879-91
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75

Beard KM, Lu H, Ho K, Fantus IG (2006) Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase. Diabetes 55, 2678-87
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76

Yu M, et al. (2006) The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem 281, 28615-26
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Jaeschke A, et al. (2006) JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 23, 899-911
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78

Shi CS, et al. (2006) The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol 26, 6511-21
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79

Tatsumi Y, et al. (2006) Involvement of the paxillin pathway in JB6 Cl41 cell transformation. Cancer Res 66, 5968-74
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