Thr383
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Home > Phosphorylation Site Page: > Thr383  -  PTEN (mouse)

Site Information
HYRYsDttDsDPENE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448315

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 3 ) , 293 (epithelial) ( 2 ) , liver ( 4 ) , U87MG (glial) ( 2 )

Upstream Regulation
Treatments:
differentiation ( 1 )

Downstream Regulation
Effects of modification on PTEN:
enzymatic activity, inhibited ( 2 )

References 

1

Zhu B, et al. (2016) TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle. Oncogene 35, 4212-24
26686089   Curated Info

2

Hodakoski C, et al. (2014) Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A 111, 155-60
24367090   Curated Info

3

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

4

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info