Thr382
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Home > Phosphorylation Site Page: > Thr382  -  PTEN (mouse)

Site Information
DHYRYsDttDsDPEN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448314

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
differentiation ( 1 )

Downstream Regulation
Effects of modification on PTEN:
enzymatic activity, inhibited ( 2 )

References 

1

Zhu B, et al. (2016) TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle. Oncogene 35, 4212-24
26686089   Curated Info

2

Hodakoski C, et al. (2014) Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A 111, 155-60
24367090   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info