Ser380
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Home > Phosphorylation Site Page: > Ser380  -  PTEN (mouse)

Site Information
EPDHYRYsDttDsDP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448313

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 , 3 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 4 ) , 293 (epithelial) ( 2 ) , MEF (fibroblast) ( 3 ) , U87MG (glial) ( 2 )

Upstream Regulation
Regulatory protein:
Huntingtin (mouse) ( 4 )
Treatments:
differentiation ( 1 ) , H2O2 ( 3 )

Downstream Regulation
Effects of modification on PTEN:
enzymatic activity, inhibited ( 2 ) , intracellular localization ( 3 )
Effects of modification on biological processes:
cell cycle regulation ( 3 )

References 

1

Zhu B, et al. (2016) TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle. Oncogene 35, 4212-24
26686089   Curated Info

2

Hodakoski C, et al. (2014) Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A 111, 155-60
24367090   Curated Info

3

Chang CJ, et al. (2008) PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol 28, 3281-9
18332125   Curated Info

4

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info